Obiettivo
COPD is characterized by emphysema (destruction of the lung alveoli) and airway disease (inflammation and thickening of the bronchial wall) both of which lead to airway obstruction. These two features co-exist in most patients but some patients present with only emphysema (E) or only airway disease (A). The aim of the project is to identify markers specific to E and A of COPD. Our hypothesis is that the mechanisms leading to these pathologies are distinct with respect to the type of inflammatory response and in terms of genetic predisposition. The differential pathogenesis for emphysema (E) and inflammatory airway disease (A) entails that in the two forms of COPD are linked to different markers at the DNA, RNA and protein level. Using computer tomography (CT) scans for selection of patients with emphysema only and airway disease only, we will obtain material from lung (leukocytes, bronchial cells) and blood (leukocytes), and will analyse elements of gene expression (SNP array, transcriptome). Data analysis will be done for E versus A (EvA) and versus a control cohort leading to identification of markers linked specifically to either E or A. These markers will be elements involved in a differential pathogenesis for the different disease processes in COPD. They can be used for diagnostic approaches and as therapeutic targets.
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Argomento(i)
Invito a presentare proposte
FP7-HEALTH-2007-A
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Meccanismo di finanziamento
CP-FP - Small or medium-scale focused research projectCoordinatore
85764 Neuherberg
Germania
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Partecipanti (14)
LE1 7RH Leicester
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CV2 2DX Coventry
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M13 9PL Manchester
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2333 ZA Leiden
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44121 Ferrara
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01138 Warszawa
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1121 Budapest
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75015 PARIS 15
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Partecipazione conclusa
1003 Lausanne
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35037 Marburg
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30625 Hannover
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75312 UPPSALA
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79106 Freiburg
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08028 Barcelona
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