Cel
EuroSyStem brings together elite European research teams to create a unique and world-leading programme in fundamental stem cell biology. By interconnecting complementary biological and computational expertise we will drive the generation of new knowledge on the characteristics of normal and abnormal stem cells. We will pave the way for application of systems methodology by measuring and modelling stem cell properties and behaviour. Information will be mined from studies in model organisms, but our primary focus is on the paradigmatic mammalian stem cells – haematopoietic, epithelial, neural and embryonic. We will compare cellular hierarchy, signalling, epigenetics, dysregulation, and plasticity. Niche dependence, asymmetric division, transcriptional circuitry and the decision between self-renewal and commitment are linked in a cross-cutting work package. A multidisciplinary approach combines transgenesis, real time imaging, multi-parameter flow cytometry, transcriptomics, RNA interference, proteomics and single cell methodologies. SMEs will contribute to the development of enhanced resolution quantitative technologies. A platform work package will provide new computational tools and database resources, enabling implementation of novel analytical and modelling approaches. EuroSyStem will engage with and provide a focal point for the European stem cell research community. The targeted collaborations within the EuroSyStem research project will be augmented by federating European research excellence in different tissues and organisms. We will organise annual symposia, training workshops, summer schools, networking and research opportunities to promote a flourishing basic stem cell research community. This network will foster interaction and synergy, accelerating progress to a deeper and more comprehensive understanding of stem cell properties. In parallel EuroSyStem will develop WEB resources, educational and outreach materials for scientists and the lay community.
Dziedzina nauki
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- natural sciencesbiological sciencescell biology
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- natural sciencesbiological sciencesgeneticsRNA
- natural sciencesbiological sciencesgeneticsepigenetics
Słowa kluczowe
Zaproszenie do składania wniosków
FP7-HEALTH-2007-A
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System finansowania
CP-IP - Large-scale integrating projectKoordynator
CB2 1TN Cambridge
Zjednoczone Królestwo
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Uczestnicy (24)
Zakończenie uczestnictwa
W1B 1AL LONDON
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EH8 9YL Edinburgh
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1015 Lausanne
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75724 Paris
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20122 Milano
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20121 Milano
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1066 CX Amsterdam
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1011 JV AMSTERDAM
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9713 GZ Groningen
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1030 Wien
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04109 Leipzig
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22100 Lund
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17177 Stockholm
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Zakończenie uczestnictwa
EH9 3JQ EDINBURGH
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OX5 PF OXFORD
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Zakończenie uczestnictwa
07973 GREIZ-GOMMIA
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Zakończenie uczestnictwa
OX14 4RY ABINGDON
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69120 Heidelberg
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20132 MILANO
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67404 Illkirch Graffenstaden
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01069 Dresden
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85764 Neuherberg
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Zakończenie uczestnictwa
OX1 2JD Oxford
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WC1E 6BT London
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