Objectif Adhesion of Plasmodium falciparum-infected erythrocytes (PE) to placental chondroitin-4-sulfate (CSA) has been linked to the severe disease outcome of pregnancy-associated malaria (PAM). After multiple pregnancies, women acquire protective antibodies that block CSA-binding and cross-react with geographically diverse placental isolates suggesting that surface molecule(s) expressed by PAM-infected erythrocytes have conserved epitopes and that a PAM vaccine may be possible. Recent evidence strongly suggests that var2CSA, a member of the P. falciparum Erythrocyte Membrane protein 1 (PfEMP1) family, may have an important role in PAM and immunity. Although var2CSA and to some extent var1CSA are the main candidates for a pregnancy malaria vaccine, experimental evidence implies that antigenic polymorphism and the lack of a small animal in vivo experimental model may pose a challenge for vaccine development. To date, efforts to develop a truly prophylactic PAM vaccine have been hindered by the difficulty in identifying immunogens that elicit broadly neutralizing and adhesion-blocking antibodies. Accordingly, a small number of highly specialized and experienced malaria research groups from Europe (6 groups) and endemic countries (2 groups) have decided to give highest priority to decipher the molecular basis for the CSA binding to the parasite ligands in order to define the common features within the different CSA-binding domains and the cross-reactive epitopes that are likely to be the targets of natural protective antibodies. This knowledge will not only be very helpful in the design of novel PfEMP1-CSA based antigens capable of inducing broad and potent neutralising antibodies to a wide variety of strains, but also to identify molecules with inhibitory capacity that could be considered for therapeutic strategies as anti-adhesive drugs. Champ scientifique medical and health scienceshealth sciencesinfectious diseasesmalarianatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesclinical medicineobstetrics Mots‑clés CSA DBL chondroitin crystallography interaction malaria plasmodium pregnancy structure Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH-2007-2.3.2-4 - Addressing knowledge gaps in pregnancy malaria Appel à propositions FP7-HEALTH-2007-A Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur INSTITUT PASTEUR Contribution de l’UE € 753 220,00 Adresse RUE DU DOCTEUR ROUX 25-28 75724 Paris France Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Contact administratif Graham Bentley (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (6) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY Italie Contribution de l’UE € 345 510,00 Adresse PADRICIANO 99 34149 Trieste Voir sur la carte Région Nord-Est Friuli-Venezia Giulia Trieste Type d’activité Research Organisations Contact administratif Shubha Narayanan (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée KOBENHAVNS UNIVERSITET Danemark Contribution de l’UE € 334 264,00 Adresse NORREGADE 10 1165 Kobenhavn Voir sur la carte Région Danmark Hovedstaden Byen København Type d’activité Higher or Secondary Education Establishments Contact administratif Ivan Kristoffersen (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITATSKLINIKUM HEIDELBERG Allemagne Contribution de l’UE € 338 251,00 Adresse IM NEUENHEIMER FELD 672 69120 Heidelberg Voir sur la carte Région Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Type d’activité Higher or Secondary Education Establishments Contact administratif Thorsten Brietz (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée ACADEMISCH ZIEKENHUIS LEIDEN Pays-Bas Contribution de l’UE € 334 473,00 Adresse ALBINUSDREEF 2 2333 ZA Leiden Voir sur la carte Région West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Type d’activité Higher or Secondary Education Establishments Contact administratif Linda Ouwerkerk (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée 4 SC AG Allemagne Contribution de l’UE € 123 003,00 Adresse FRAUNHOFERSTR. 22 82152 PLANEGG MARTINSRIED Voir sur la carte Région Bayern Oberbayern München, Landkreis Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Dagmar Schirm (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France Contribution de l’UE € 81 000,00 Adresse RUE DE TOLBIAC 101 75654 Paris Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Contact administratif Isabelle Pires (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
