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Contenuto archiviato il 2024-06-18

EUROPEAN DRUG INITIATIVE ON CHANNELS AND TRANSPORTERS

Obiettivo

The European Drug Initiative on Channels and Transporters, EDICT, allies for the first time, partners with world-class expertise in both the structural and functional characterisation of membrane channels and transporters. State-of-the-art facilities and personnel for X-ray crystallography, Electron Microscopy and Nuclear Magnetic Resonance and the latest throughput technology, will provide infrastructure for scientists characterising channel and transport functions in man and pathogenic microorganisms. Our experts in the analyses of all the databases of these membrane proteins and molecular modelling will work with our industrial partners on specific targets chosen for their potential to improve the health of European citizens, increase the competitiveness of European health-related industries and businesses and address global health issues. EDICT will increase knowledge of biological processes and mechanisms involved in normal health and in specific disease situations, and transpose this knowledge into clinical applications. By combining computational and experimental analyses, existing detailed molecular models of channel and transporter proteins, and novel structures derived by our partners, will be analysed to identify the critical regions constituting drug targets. These basic discoveries will be translated via in silico and experimental strategies with our industrial partners into the design of novel drugs that modify activities of the membrane proteins for the benefit of the patients. The range of human proteins covered includes potassium channels, anion and cation transporters, neurotransmitter transporters, cation-transporting ATPases and mitochondrial transporters. Structures of bacterial homologues to the human proteins are exploited to inform the studies of their human counterparts

Campo scientifico

Parole chiave

Programma(i)

Argomento(i)

Invito a presentare proposte

FP7-HEALTH-2007-A
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Meccanismo di finanziamento

CP-IP - Large-scale integrating project

Coordinatore

UNIVERSITY OF LEEDS
Contributo UE
€ 1 890 220,87
Indirizzo
WOODHOUSE LANE
LS2 9JT Leeds
Regno Unito

Mostra sulla mappa
Regione
Yorkshire and the Humber West Yorkshire Leeds
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Kathy Brownridge (Ms.)
Collegamenti
Costo totale
Nessun dato

Partecipanti (27)

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Ultimo aggiornamento: 9 Febbraio 2022

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Permalink: https://cordis.europa.eu/project/id/201924/it

European Union, 2024