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Zawartość zarchiwizowana w dniu 2024-06-18

EUROPEAN DRUG INITIATIVE ON CHANNELS AND TRANSPORTERS

Cel

The European Drug Initiative on Channels and Transporters, EDICT, allies for the first time, partners with world-class expertise in both the structural and functional characterisation of membrane channels and transporters. State-of-the-art facilities and personnel for X-ray crystallography, Electron Microscopy and Nuclear Magnetic Resonance and the latest throughput technology, will provide infrastructure for scientists characterising channel and transport functions in man and pathogenic microorganisms. Our experts in the analyses of all the databases of these membrane proteins and molecular modelling will work with our industrial partners on specific targets chosen for their potential to improve the health of European citizens, increase the competitiveness of European health-related industries and businesses and address global health issues. EDICT will increase knowledge of biological processes and mechanisms involved in normal health and in specific disease situations, and transpose this knowledge into clinical applications. By combining computational and experimental analyses, existing detailed molecular models of channel and transporter proteins, and novel structures derived by our partners, will be analysed to identify the critical regions constituting drug targets. These basic discoveries will be translated via in silico and experimental strategies with our industrial partners into the design of novel drugs that modify activities of the membrane proteins for the benefit of the patients. The range of human proteins covered includes potassium channels, anion and cation transporters, neurotransmitter transporters, cation-transporting ATPases and mitochondrial transporters. Structures of bacterial homologues to the human proteins are exploited to inform the studies of their human counterparts

Dziedzina nauki

Słowa kluczowe

Program(-y)

Temat(-y)

Zaproszenie do składania wniosków

FP7-HEALTH-2007-A
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System finansowania

CP-IP - Large-scale integrating project

Koordynator

UNIVERSITY OF LEEDS
Wkład UE
€ 1 890 220,87
Adres
WOODHOUSE LANE
LS2 9JT Leeds
Zjednoczone Królestwo

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Region
Yorkshire and the Humber West Yorkshire Leeds
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Kathy Brownridge (Ms.)
Linki
Koszt całkowity
Brak danych

Uczestnicy (27)

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Ostatnia aktualizacja: 9 Lutego 2022

Moja broszura

Permalink: https://cordis.europa.eu/project/id/201924/pl

European Union, 2024