Obiettivo The main objectives of the proposed reintegration research grant are: 1) to investigate the molecular causes of diabetic embryopathy; 2) to transfer my knowledge and experience to the Czech and European academia and industry; and 3) to develop a network of future international research collaboration dealing with diabetes. The scientific objective is to understand how maternal diabetes affects the developing embryo and increases the risk for heart malformations. The risk for birth defects is up to 10-fold higher in diabetic than in non-diabetic pregnancies. With increasing prevalence of diabetes in women of childbearing age, diabetes becomes a major cause of mortality and health problems in infants born to diabetic mothers. Although the teratogenic effects of maternal diabetes are well documented, the molecular causes remain elusive. Using global expression profiling, our team discovered that the exposure to maternal diabetes deregulated 126 genes in developing embryos. Many of these genes are already known to be involved in heart defects or affect heart functions. In this project I propose: 1) to define which genes can serve as predictive markers for specific abnormalities in heart development; 2) to determine cell-type specificity of diabetes-deregulated genes within the developing heart; 3) to identify specific time points, which are the most susceptible for induction of changes in the heart; and 4) to investigate the role of HIF1-controlled-hypoxia-response pathways in diabetic embryopathy. Understanding the molecular causes of diabetic embryopathy will form the basis for future strategies to prevent birth defects associated with diabetic pregnancies. The reintegration objectives will be achieved via my appointment as an independent Group Leader at the Institute of Molecular Genetics of the Academy of Sciences of the Czech Republic, where I will be responsible for team building, training, teaching, and conducting high quality collaborative research. Campo scientifico scienze naturaliscienze biologichebiologia molecolaregenetica molecolarescienze mediche e della salutemedicina clinicaendocrinologiadiabetescienze mediche e della salutemedicina clinicaostetriciascienze mediche e della salutemedicina clinicaembriologiascienze socialiscienze politichesistemi di governo Parole chiave Diabetes Hypoxia-inducible factor 1 pathways congenital malformations diabetic pregnancy embryonic development gene expression heart defects quantitative RT-PCR Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) PEOPLE-2007-4-3.IRG - Marie Curie Action: "International Reintegration Grants" Invito a presentare proposte FP7-PEOPLE-2007-4-3-IRG Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IRG - International Re-integration Grants (IRG) Coordinatore BIOTECHNOLOGICKY USTAV AV CR VVI Indirizzo Prumyslova 595 252 50 Vestec Cechia Mostra sulla mappa Regione Česko Střední Čechy Středočeský kraj Tipo di attività Other Contatto amministrativo Jan Skoda (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Contributo UE Nessun dato
