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Studies Investigating Co-morbidities Aggravating Heart Failure

Cel

Chronic heart failure (CHF) is a massive clinical, social and economic problem. Diabetes and obesity increase the risk of developing CHF. Cachexia is also an ominous sign. In 13 clinical and preclinical research projects, SICA-HF aims to investigate the impact of these co-morbidities in CHF patients at the clinical, vascular, cellular and molecular levels. SICA-HF will enrol >1600 patients with CHF, >300 patients with type 2 diabetes without CHF and >150 healthy control subjects. We will ensure that 50% of subjects are women and that group mean ages are similar. Clinical investigations using standardised protocols will focus on body composition, insulin resistance, exercise capacity, cardiopulmonary reflex patterns and peripheral blood flow. Subjects will be assessed at baseline, after 4-6 months, 16-18 months and at annual intervals thereafter. Outcome variables include morbidity and mortality and data on incidence and prevalence of type 2 diabetes, obesity and cachexia among CHF patients. A strength of this proposal is that clinical and preclinical researchers will study the same patients, as blood and tissue samples from patients being clinically evaluated will be sent to partner research laboratories. Such interaction is very rare in large-scale studies and allows integration of clinical and preclinical findings. The Central Blood and DNA Banks on the EU and the Russian side of the consortium permit validation of established and investigation of novel biomarkers. Pathophysiological pathways that are found to be important in the heart failure co-morbidity interaction will be further analysed mechanistically in in-vitro and in animal models. We aim to validate clinical study results in experimental settings towards the end of the project (year 3 & 4), particularly focusing on adipose tissue, skeletal muscle and (endothelial) progenitor cells. Our studies aim to enable developing tailored therapies for CHF patients with type 2 diabetes, obesity and cachexia.

Zaproszenie do składania wniosków

FP7-HEALTH-2009-single-stage
Zobacz inne projekty w ramach tego zaproszenia

Koordynator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Adres
Chariteplatz 1
10117 Berlin
Niemcy

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Eveline Fräßdorf (Ms.)
Wkład UE
€ 1 567 329,30

Uczestnicy (12)

UNIVERSITY OF HULL
United Kingdom
Wkład UE
€ 484 859
Adres
Cottingham Road
HU6 7RX Hull

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Alexandra Galbraith (Ms.)
UNIWERSYTET MEDYCZNY IM PIASTOW SLASKICH WE WROCLAWIU
Polska
Wkład UE
€ 232 611
Adres
Ul Pasteura 1
50 367 Wroclaw

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Piotr Ponikowski (Prof.)
SAN RAFFAELE S.p.A.
Włochy
Wkład UE
€ 225 234
Adres
Via Di Val Cannuta 247
00166 Roma

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Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Mario Calandriello (Dr.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Niemcy
Wkład UE
€ 172 504
Adres
Carl-neuberg-strasse 1
30625 Hannover

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Johanna Grunert (Ms.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG
Niemcy
Wkład UE
€ 177 960
Adres
Oskar Von Miller Ring 29
80333 Muenchen

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Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Birgit Fuchs (Mrs.)
UNIVERSITAET ROSTOCK

Zakończenie uczestnictwa

Niemcy
Wkład UE
€ 9 614,70
Adres
Universitatsplatz 1
18055 Rostock

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Margitta Paucker
ALMAZOV FEDERAL HEART, BLOOD AND ENDOCRINOLOGY CENTRE, FEDERATION AGENCY ON HIGH MEDICAL TECHNOLOGIES
Rosja
Adres
Akkuratova Str. 2
197341 Saint-petersburg

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Research Organisations
Kontakt administracyjny
Eugeniy V. Shlyakhto (Prof.)
M.V. LOMONOSOV MOSCOW STATE UNIVERSITY
Rosja
Adres
Leninskie Gory
119992 Moscow

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Higher or Secondary Education Establishments
Kontakt administracyjny
Vsevolod Tkachuk (Prof.)
INSTITUTION OF RUSSIAN ACADEMY OF MEDICAL SCIENCES SCIENTIFIC RESEARCHINSTITUTE OF CARDIOLOGY OF SIBERIAN DEPARTMENT OF RAMS
Rosja
Adres
Kievskaya Str. 111a
634012 Tomsk

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Rodzaj działalności
Research Organisations
Kontakt administracyjny
Rostislav Karpov (Prof.)
RUSSIAN CARDIOLOGY RESEARCH AND PRODUCTION COMPLEX
Rosja
Adres
Cherepkovskaya 3
121552 Moscow

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Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Kontakt administracyjny
Eugene Chazov (Mr.)
UNIVERZITETNA KLINIKA ZA PLJUCNE BOLEZNI IN ALERGIJO GOLNIK
Słowenia
Wkład UE
€ 59 646
Adres
Golnik 36
4204 Golnik

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Barbara Gazvoda (Ms.)
SLASKIE CENTRUM CHOROB SERCA W ZABRZU
Polska
Wkład UE
€ 69 600
Adres
Ul. Marii Curie Sklodowskiej 9
41800 Zabrze

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Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Bożena Duda (Ms.)