Cel
Tuberculosis (TB) is a re-emerging global health threat caused by Mycobacterium tuberculosis (Mtb). One third of the world's population is infected with Mtb and new infections occur at a rate of one per second. Despite global research efforts, mechanisms underlying pathogenesis, virulence and persistence of Mtb infection remain poorly understood. Simple reductionist approaches are insufficient to understand its complex biology. The grand goal of the SysteMTb project is to establish a Systems Biology framework to understand key features of Mtb and its interactions with the host which, in turn, will provide new insights and a solid (model based) knowledge for the development of novel and cost-effective strategies to combat tuberculosis. To achieve this, SysteMTb will: i) generate and integrate quantitative data sets of Mtb (e.g. transcriptomics, proteomics, metabolomics, structural genomics, lipidomics, glycomics) alone, or in the presence of host macrophages, ii) develop computer models at different appropriate levels of system complexity with emphasis on metabolism, regulatory networks and transcription regulation, and iii) identify new possible targets for therapeutic intervention based on computer modelling. The combination of these approaches will provide a rational framework to understand mycobacterial physiology during infection and to identify essential nodes that are optimal for effective therapeutic interventions.
Dziedzina nauki
Zaproszenie do składania wniosków
FP7-HEALTH-2009-two-stage
Zobacz inne projekty w ramach tego zaproszenia
System finansowania
CP-IP - Large-scale integrating projectKoordynator
08003 Barcelona
Hiszpania
Zobacz na mapie
Uczestnicy (13)
80539 Munchen
Zobacz na mapie
W1B 1AL LONDON
Zobacz na mapie
75794 Paris
Zobacz na mapie
8092 Zuerich
Zobacz na mapie
02 106 Warszawa
Zobacz na mapie
16610 Praha 6
Zobacz na mapie
69117 Heidelberg
Zobacz na mapie
13100 Vercelli
Zobacz na mapie
08028 BARCELONA
Zobacz na mapie
38126 Braunschweig
Zobacz na mapie
10117 Berlin
Zobacz na mapie
6708 PB Wageningen
Zobacz na mapie
3000 Leuven
Zobacz na mapie