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Dissecting the Immunological Interplay between Poverty Related Diseases and Helminth Infections: An African-European Research Initiative

Obiettivo

Worm infections are receiving increased attention due to: the wide geographic overlap in occurrence between worms and HIV, TB and malaria; the large proportion of individuals (minimal estimates around 25%) co-infected with worms and HIV/TB/ malaria; the potential risk of increasing disease burden; the very limited understanding of the impact by worm infections on HIV-, TB- and malaria-specific immune responses and on their clinical outcome; the lack of established intervention guidelines for treatment of worm infections; and the scarce information on the impact by worm infections on vaccination and vaccine-induced immune responses. In order to address these complex and challenging scientific issues, IDEA project will focus its efforts on four primary objectives: a) the worm-induced modulation of the functional and molecular profile of HIV-, TB- and malaria-specific immune responses, b) the impact by worm co-infections on measures of disease activity of PRDs, c) the immunologic markers of worm-, HIV-, TB- and malaria-specific immune responses associated with better control of pathogen replication and disease, and d) the modulation by worm co-infections of vaccine-induced immune responses. To achieve these objectives, IDEA project has developed a global and innovative strategy which includes: a) the alliance between African and European leading scientists in the field of worms, HIV, TB and malaria, b) the multidisciplinary expertise involving immunologists, parasitologists, epidemiologists, clinicians, and experts in vaccines, c) cutting edge immunology and the most innovative technologies to profile immune response, d) the access to large cohort studies bringing a number of centres working on worms and PRDs in Africa together, and e) the access to experimental HIV, TB and malaria vaccine candidates under clinical development in Africa.

Invito a presentare proposte

FP7-HEALTH-2009-single-stage
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Coordinatore

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Indirizzo
Rue du bugnon 21
1011 Lausanne
Svizzera

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Regione
Schweiz/Suisse/Svizzera Région lémanique Vaud
Tipo di attività
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contatto amministrativo
Giuseppe Pantaleo (Prof.)
Collegamenti
Contributo UE
Nessun dato

Partecipanti (22)