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Cancer Genomics of the Kidney

Obiettivo

The International Cancer Genome Consortium (ICGC) has the goal of obtaining a comprehensive description of genomic, transcriptomic and epigenomic changes in 50 different tumour types and/or subtypes, with the aim of elucidating the genomic changes present in the many forms of cancers that contribute to the burden of disease throughout the world. We present a proposal for a European contribution to this effort through application of state-of-the-art approaches to the genomics of the most common form of renal cell cancer (RCC). RCC is of particular importance within Europe where the highest global incidence rates are observed. Disease incidence has increased over the last two decades, and it is now the 8th most common cancer in the EU. CAGEKID brings clinical and epidemiological resources that are unique worldwide together with the necessary genetics and genomics expertise required for this effort. In the first phase of the study, we will provide a full genomic characterisation of 100 matched pairs of DNA extracted from the tumour and constitutional samples. DNA will be completely sequenced, and the data brought together with those from whole genome transcript and methylation analyses. Follow-up studies of potential targets will be made in further samples. The results acquired will be relied to targeted protein analyses. The primary data will be made available to the scientific community, and the programme will contribute to establishing norms for the manipulation and storage of biological samples. CAGEKID will provide the first systematic analysis of this tumour site providing new insights into disease aetiology with application for diagnosis and treatment. It addresses a major need to identify new biological markers for renal cell cancer, one of very few tumour types for which there are currently no biological markers in routine clinical use. Renal cancer is not yet supported by any of the members of the ICGC.

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Coordinatore

FONDATION JEAN DAUSSET CENTRE D'ETUDE DU POLYMORPHISME HUMAIN FONDATION
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75010 Paris 10
Francia

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Contatto amministrativo
Jean-François Deleuze (Dr.)
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€ 3 007 900,01

Partecipanti (14)

CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER
Francia
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€ 1 126 500
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150 Cours Albert Thomas
69372 Lyon Cedex 08

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Olaf Kelm (Dr.)
UNIVERZITA KARLOVA
Cechia
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€ 175 500
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Ovocny Trh 560/5
116 36 Praha 1

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Higher or Secondary Education Establishments
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Kristyna Matejkova
PROTIVORAKOVOE OBSHESTVO ROSSII
Russia
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€ 530 500
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Kashirskoye Shosse 24
115478 Moskva

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Contatto amministrativo
David Zaridze (Prof.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germania
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€ 485 375
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Meyerhofstrasse 1
69117 Heidelberg

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Tom Ratcliff (Mr.)
KAROLINSKA INSTITUTET
Svezia
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Nobels Vag 5
17177 Stockholm

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Kristina Geiger (Ms.)
Centre Bioengineering of the Russian academy of sciences
Russia
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Prosp. 60-let Oktiabria 7-1
117312 Moscow

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UNIVERSITY OF LEEDS
United Kingdom
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KUNGLIGA TEKNISKA HOEGSKOLAN
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COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Francia
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Rue Leblanc 25
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Elizabeth May (Ms.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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Cédrine Pederiva (Ms.)
LATVIJAS UNIVERSITATES MATEMATIKAS UN INFORMATIKAS INSTITUTS
Lettonia
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Raina Bulvaris 29
1459 Riga

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Inara Opmane (Ms.)
UPPSALA UNIVERSITET
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Von Kraemers Alle 4
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Fredrik Ponten (Prof.)
RUSSIAN RESEARCH CENTRE KURCHATOV INSTITUTE
Russia
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123182 Moscow

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Oleg Akilin (Mr.)
ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY
Canada
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H3A0G4 Montreal

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Olga Naiberger (Ms.)