Final Report Summary - BIOMEMOS (Higher order structure and function of biomembranes)
The BIOMEMOS project has revealed a number of important details of the structure, function and mechanism of P-type ATPases, and the findings have been disseminated through numerous channels ranging from the most prestigious scientific journals to industry collaborations, innovation projects, and broadcasts in public media. As one example new insight into the regulation of the highly active calcium pump in muscle tissue by membrane lipids and how it is slowed down by a small protein called sarcolipin, which is also implicated in the regulation of the body temperature. Another good example is a series of studies of the sodium-potassium pump on how it pumps Na+ ions out of the cell and is affected by mutations associated with neurological diseases and Conn's disease causing hypertension. Another important aspect of BIOMEMOS has been in methods development, and a number of new methods and approaches in membrane research of general interest to a large community has been developed aiming also for new future research activities and biotechnology.