Obiettivo Due to the emerging resistance of bacterial pathogens against commonly used drugs, there is an urgent requirement for new antibiotic compounds and lead structures. The European Commission encouraged researchers to investigate this problem in a holistic manner. Recently bacteria with complex lifestyles and intensive “crosstalk” came into focus as potential source for new small molecule lead structures which might be further developed as therapeutic agents. Planctomycetes comprise ideal candidates, since these ubiquitous occurring organisms, which reproduce via budding, form cell aggregates, such as biofilms and “marine-snow”. Beside their complex lifestyle, they comprise sub cellular compartments resembling the eukaryotic nucleus which questions the pro-/eukaryotic dichometrie. Thus, they combine a complex lifestyle with interspecies communication, which is required for biofilm formation. However, in-depth analysis of Planctomycetes secondary metabolite production has been hampered by the lack of a genetic system. Consequently the major objective of this proposal is the construction of a genetic system for Planctomycetes. Such a system would allow e.g. the construction of deletion mutants and the identification of secondary metabolites while comparing these mutants against the wild type strain. In addition the genetic system will be highly beneficial for applications beyond the proposed project, since e.g. genetic modification of Planctomycetes which play an important role in waste water treatment will result in further biotechnological applications. In addition to the development of the genetic system, the capability of small molecule synthesis will be investigate via genome mining of the already sequenced Planctomycetes species. Further more surrogate genetic experiments will allow the cloning and heterologous expression of secondary-metabolite related genes and operons, which subsequently enables small molecule structure determination and characterization. Campo scientifico engineering and technologyenvironmental engineeringwater treatment processeswastewater treatment processesnatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesmedical biotechnologygenetic engineeringnatural sciencesbiological sciencesgeneticsgenomes Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2009-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Invito a presentare proposte FP7-PEOPLE-2009-IOF Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IOF - International Outgoing Fellowships (IOF) Coordinatore LEIBNIZ-INSTITUT DSMZ-DEUTSCHE SAMMLUNG VON MIKROORGANISMEN UND ZELLKULTUREN GMBH Contributo UE € 238 099,90 Indirizzo INHOFFENSTRASSE 7B 38124 Braunschweig Germania Mostra sulla mappa Regione Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt Tipo di attività Research Organisations Contatto amministrativo Heike Bauer (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Partecipazione conclusa Germania Contributo UE Nessun dato Indirizzo HOFGARTENSTRASSE 8 80539 Munchen Mostra sulla mappa Regione Bayern Oberbayern München, Kreisfreie Stadt Tipo di attività Research Organisations Contatto amministrativo Heike Wojack (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
