Cel
DINAMICS aims to promote the uptake of nano-technological approaches by developing an integrated cost-effective nano-biological sensor for detection of bioterrorism and environmental assays. The prime deliverable is an exploitable lab-on-a-chip device for detection of pathogens in water using on-the-spot recognition and detection based on the nano-technological assembly of unlabelled DNA.
DINAMICS will integrate DNA hybridisation sensors with micro-fluidics and signal conditioning/processing both on silicon and polymer substrates avoiding the use of external apparatus for fluid handling, electrical signal generation and processing, based on DNA hybridisation. A sensory breakthrough will be achieved trough two complementary technological solutions: Measurements based on electrical (capacitive) signals. If hybridisation occurs between target and probe the detected change can be functionalised. Detection through UV light absorption. Based on the recognition of different UV absorptions induced by DNA hybridisation.
The development of a system where each sensing site in the micro-array contains a UV micro-fabricated sensor is a goal of the project. After DNA hybridisation the whole array is illuminated with UV light and the absorption of each site is measured by the sensor. The project will culminate in an integrated multi-technology product that will be high tech, low cost and time efficient sensing device applicable for use in the water industry via the coordination of nano and bio technologies with new sensory science to deliver a product that will lead to major changes in the way the testing and diagnostics of harmful substances is done. Both methodologies will ensure an additional and reliable source of cost-reduction through a drastic shortening of the sensing pipeline and without the need of transferring the samples to an analytical laboratory.
Dziedzina nauki
- social sciencespolitical sciencespolitical transitionsterrorism
- natural sciencesbiological sciencesgeneticsDNA
- engineering and technologyother engineering and technologiesmicrotechnologylab on a chip
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
- engineering and technologycivil engineeringwater engineeringwater supply systems
Zaproszenie do składania wniosków
FP6-2004-NMP-SME-4
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