Skip to main content
European Commission logo
italiano italiano
CORDIS - Risultati della ricerca dell’UE
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary
Contenuto archiviato il 2024-06-18

Chromatin Dynamics of Stem Cells and Lineage Commitment in Plant Development

Obiettivo

In recent years chromatin has emerged as an extremely dynamic platform for establishing and maintaining gene expression programs. Chemical alterations of DNA and histone proteins, nucleosome positioning and histone variant usage collectively allow the formation of complex combinatorial codes of chromatin modifications that determine local DNA accessibility to transcription and transcript processing machineries.
As in animals, plant stem cell identity and lineage commitment are controlled by unique transcription factor networks and conserved chromatin factors including nucleosome remodelers, histone variants and histone modifiers of the Polycomb group (PcG, epigenetic repressors) as well as Trithorax group (TrxG, epigenetic activators). Moreover, in stem cells the histone variant H2A.Z collaborates with PcG factors and is pivotal for timely activation of differentiation genes during the transition to lineage commitment.
Although more of these tantalizing concepts in the plant and animal chromatin field have recently surfaced non have hitherto been proven in vivo by studying specific cell types derived from developing organisms.
I believe plants can become the next stepping-stone in our understanding of these developmental chromatin concepts. Due to lack of cell migration, easy supply of in vivo derived material as well as extensive collections of genetic backgrounds plants offer a unparalleled opportunity to study cell type specific chromatin changes along the trajectory of cell lineage commitment. I here propose to use Arabidopsis root development as a model system in combination with fluorescence assisted cell sorting, chromatin immuno-precipitation and genome-wide analysis of a set of chromatin parameters. This unique study will reveal parallels and diverging concepts of plant and animal development at the chromatin level and generate a deeper understanding of plant patterning processes that could lead to substantial crop improvements.

Invito a presentare proposte

FP7-PEOPLE-2010-RG
Vedi altri progetti per questo bando

Coordinatore

WAGENINGEN UNIVERSITY
Contributo UE
€ 18 750,00
Indirizzo
DROEVENDAALSESTEEG 4
6708 PB Wageningen
Paesi Bassi

Mostra sulla mappa

Regione
Oost-Nederland Gelderland Veluwe
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Wim De Wijse
Collegamenti
Costo totale
Nessun dato

Partecipanti (1)