Obiettivo
EpoCan aims to develop and implement a comprehensive interdisciplinary strategy to assess the long-term risks of erythropoietin (EPO) and its derivatives (epoetins) on tumour growth progression and thromboembolic events in cancer patients, cardiovascular events, and the development of cancer in chronic kidney disease. Approximately 400,000 patients across Europe receive epoetins treatment each year. Recent meta-analysis data have raised concerns over increased mortality in some patient groups. Hence the urgent need to evaluate the risk-benefit ratio of epoetin treatment and its potential long-term effects.
EpoCan brings together a multidisciplinary consortium of 12 world leading academic, industrial and medical partners, with long-standing, complementary expertise in haemostasis, oncology and EPO biology. EpoCan aims to (1) Identify, detect and measure possible long-term hazards of epoetin treatment; (2) Develop novel prognostic tools and new complementary therapeutic reagents: (3) Evaluate the risk-benefit ratio to pave the way for new safety and efficacy criteria.
EpoCan will: (a) Utilize a wide array of cellular models to thoroughly analyze EPO/EPO receptor(EPO-R)interaction and signalling, to define the relationship between EPO-R expression in tumour samples and the clinical outcome in cancer patients; (b) Establish and test new, personalized, predictive tools (EPO-R peptide antagonists, novel specific anti-EPO-R monoclonal antibodies, thromboembolic tests); (c) Create new murine models as hosts for tumour implantation subjected to EPO and derivatives established above; (d) Screen and analyze clinical databases; (e) Define models to predict hazardous versus safe/beneficial roles of epoetins in the treatment of cancer and kidney failure associated anaemia. Data obtained will be integrated into coherent models using novel computational algorithms developed for EpoCan. Results are expected to have broad ramifications, with special relevance for clinical oncology.
Campo scientifico
Argomento(i)
Invito a presentare proposte
FP7-HEALTH-2011-single-stage
Vedi altri progetti per questo bando
Meccanismo di finanziamento
CP-FP - Small or medium-scale focused research projectCoordinatore
69978 Tel Aviv
Israele
Mostra sulla mappa
Partecipanti (12)
BT7 1NN Belfast
Mostra sulla mappa
8006 ZURICH
Mostra sulla mappa
45141 Essen
Mostra sulla mappa
28049 Madrid
Mostra sulla mappa
3584 CX Utrecht
Mostra sulla mappa
2333 ZA Leiden
Mostra sulla mappa
1210 Wien
Mostra sulla mappa
6020 Innsbruck
Mostra sulla mappa
80636 Munich
Mostra sulla mappa
79111 FREIBURG
Mostra sulla mappa
67017 TEL AVIV-JAFFO
Mostra sulla mappa
7608665 Rehovot
Mostra sulla mappa