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MODeling the EnviRonmental and human health effects of Nanomaterials (MODERN)

Obiettivo

Nano-sized materials are a common element in many industrial processes mainly due to their unique properties that lead to the production of high technology products. The widespread use of nanotechnology requires the consideration of the environmental and human health risks that may result from the introduction of engineered nanoparticles (eNPs) into the environment. Although toxic effects for certain types of eNP have been recently reported, there is still a lack of knowledge about their possible long-term effects in biological systems.
The project focuses on the understanding of the processes governing the interactions of nanoparticles with biological systems and their associated mechanisms of toxicity, which are essential for eNP safety assessment. Information on the effects of well characterized eNPs will be obtained from literature and other data repositories. Targeted in vivo and in vitro experiments will be also carried out to overcome the limitations of data availability and for model validation. Computational methods will be applied to model both nanostructure-property relationships and the complex and highly non-linear nano-bio interactions and to diminishing the need for animal testing.
The main goal of MODERN is to establish new modeling approaches suitable for relating nanotoxicity with the intrinsic molecular and physicochemical properties of eNPs at environmental exposure levels and to implement safe-by-design nanoparticle design strategies. This implies three specific objectives: (i) To apply computational models for the characterization of the structural and physicochemical properties leading to QNPRs and safe-by-design strategies for eNPs; (ii) to develop in silico models (QNAR) of biological activity of eNPs in the body and in the environment; and (iii) to establish a categorization and hazard ranking protocol for eNPs based on structural similarity principles and in the analysis of their toxicological profiles.

Invito a presentare proposte

FP7-NMP-2012-SMALL-6
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Coordinatore

UNIVERSITAT ROVIRA I VIRGILI
Indirizzo
Carrer De Escorxador
43003 Tarragona
Spagna
Tipo di attività
Higher or Secondary Education Establishments
Contributo UE
€ 268 515
Contatto amministrativo
Rosa Sola-Alberich (Dr.)

Partecipanti (6)

HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ
Germania
Contributo UE
€ 191 999
Indirizzo
Permoserstrasse 15
04318 Leipzig
Tipo di attività
Other
Contatto amministrativo
Annette Schmidt (Ms.)
AARHUS UNIVERSITET
Danimarca
Contributo UE
€ 132 000
Indirizzo
Nordre Ringgade 1
8000 Aarhus C
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Lene Birksø Bødskov (Mrs.)
KEEMILISE JA BIOLOOGILISE FUUSIKA INSTITUUT
Estonia
Contributo UE
€ 160 280
Indirizzo
Akadeemia Tee 23
12618 Tallinn
Tipo di attività
Other
Contatto amministrativo
Toomas Välimäe (Mr.)
UNIVERSITAET BREMEN
Germania
Contributo UE
€ 145 025
Indirizzo
Bibliothekstrasse 1
28359 Bremen
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Thomas Flink
TARTU ULIKOOL
Estonia
Contributo UE
€ 101 997
Indirizzo
Ulikooli 18
51005 Tartu
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Kaido Tamm (Dr.)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Stati Uniti
Indirizzo
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
David Avery (Mr.)