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Studies on a cohort of Serbian children exposed to x-irradiation to determine the contribution of the non-coding genome to
susceptibility at low doses

Obiettivo

"The epidemiological study of Tinea capitis (ringworm) patients has proven useful for the study of carcinogenic effects of low dose radiation. In Dark.risk we will develop a new epidemiological cohort based upon the 24 000 cases irradiated in childhood that we will document to create the Serbian Registry of Tinaea Capitis Children (SRTCC). Unlike many other epidemiological cohorts SRTCC can be used to collect biological materials for molecular epidemiological studies.

Dark.risk will prepare the way to use SRTCC biomaterials to quantify the contribution of individual differences in sensitivity to risk from low doses of ionizing radiation. We will focus on a novel and unique process to identify individual differences. Until recently 95% of the human genome was considered to be non-translated “junk"" DNA. However, almost all of this “dark matter” is actively transcribed into a vareity of non-coding RNA species (ncRNAs) that regulate interactions with the external environment, such as repressing retrotransposons, regulating gene transcription responses to stress, governing chromatic remodeling and coordinating the translation of mRNAs. The ncRNAs play an essential role in coordinating critical cellular responses to radiation such as maintenance of genomic stability, senescence, apoptosis and survival. As ncRNAs make major contributions to individual disease sensitivity we will investigate precisly how the “dark matter” regulates responses at low doses (1mGy to 500mGy), and how these responses vary between individuals.

Our long-term goal is to use ncRNAs as biological markers of exposure and outcome on an individual basis."

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FP7-Fission-2012
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Meccanismo di finanziamento

CP - Collaborative project (generic)

Coordinatore

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Indirizzo
Ingolstadter Landstrasse 1
85764 Neuherberg
Germania
Tipo di attività
Research Organisations
Contributo UE
€ 640 612
Contatto amministrativo
Juergen Ertel (Dr.)

Partecipanti (4)

"ZENSKA ASOCIJACIJA ""ROSA"""
Serbia
Contributo UE
€ 148 233
Indirizzo
Luke Vojvodica 35
11000 Beograd
Tipo di attività
Research Organisations
Contatto amministrativo
Marija Tasic (Dr.)
AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE
Italia
Contributo UE
€ 309 318
Indirizzo
Lungotevere Grande Ammiraglio Thaon Di Revel 76
00196 Roma
Tipo di attività
Research Organisations
Contatto amministrativo
Annamaria Margari (Dr.)
UNIVERSIDAD AUTONOMA DE BARCELONA
Spagna
Contributo UE
€ 353 287
Indirizzo
Calle Campus Universitario Sn Cerdanyola V
08290 Cerdanyola Del Valles
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Francisca Rabadán Sotos (Ms.)
SERVIZO GALEGO DE SAUDE
Spagna
Contributo UE
€ 278 550
Indirizzo
Edificio Administrativo San Lázaro
15703 Santiago De Compostela
Tipo di attività
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contatto amministrativo
Jose-Luis Fernandez-Garcia (Dr.)