Obiettivo The actual view of cellular transformation and cancer progression supports the notion that cancer cells must undergo metabolic reprogramming in order to survive in a hostile environment. This field has experienced a renaissance in recent years, with the discovery of cancer genes regulating metabolic homeostasis, in turn being accepted as an emergent hallmark of cancer. Prostate cancer presents one of the highest incidences in men mostly in developed societies and exhibits a significant association with lifestyle environmental factors. Prostate cancer recurrence is thought to rely on a subpopulation of cancer cells with low-androgen requirements, high self-renewal potential and multidrug resistance, defined as cancer-initiating cells. However, whether this cancer cell fraction presents genuine metabolic properties that can be therapeutically relevant remains undefined. In CancerMetab, we aim to understand the potential benefit of monitoring and manipulating metabolism for prostate cancer prevention, detection and therapy. My group will carry out a multidisciplinary strategy, comprising cellular systems, genetic mouse models of prostate cancer, human epidemiological and clinical studies and bioinformatic analysis. The singularity of this proposal stems from the approach to the three key aspects that we propose to study. For prostate cancer prevention, we will use our faithful mouse model of prostate cancer to shed light on the contribution of obesity to prostate cancer. For prostate cancer detection, we will overcome the consistency issues of previously reported metabolic biomarkers by adding robustness to the human studies with mouse data integration. For prostate cancer therapy, we will focus on a cell population for which the metabolic requirements and the potential of targeting them for therapy have been overlooked to date, that is the prostate cancer-initiating cell compartment. Campo scientifico medical and health sciencesclinical medicineoncologyprostate cancermedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistancemedical and health sciencesbasic medicinephysiologyhomeostasismedical and health scienceshealth sciencesnutritionobesity Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-SG-LS4 - ERC Starting Grant - Physiology, Pathophysiology and Endocrinology Invito a presentare proposte ERC-2013-StG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-SG - ERC Starting Grant Istituzione ospitante ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS Contributo UE € 1 498 686,00 Indirizzo PARQUE TECNOLOGICO EDIFICIO 801 A 48160 Derio Vizcaya Spagna Mostra sulla mappa Regione Noreste País Vasco Bizkaia Tipo di attività Research Organisations Ricercatore principale Arkaitz Carracedo Perez (Dr.) Contatto amministrativo Alfonso Egaña Barrenechea (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS Spagna Contributo UE € 1 498 686,00 Indirizzo PARQUE TECNOLOGICO EDIFICIO 801 A 48160 Derio Vizcaya Mostra sulla mappa Regione Noreste País Vasco Bizkaia Tipo di attività Research Organisations Ricercatore principale Arkaitz Carracedo Perez (Dr.) Contatto amministrativo Alfonso Egaña Barrenechea (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato