Cel The objective of this Apotherapy Specific Targeted Research Project proposal is to establish a European collective of international scientific excellence to combat cancer by translating basic research on key apoptotic pathways into tools which will improve the treatment and quality of life of cancer sufferers. The project will specifically aim to exploit the widespread expression of CD40, a TNF receptor family member, in human tumours and develop CD40 ligand-based modalities with high therapeutic potential and minimal side-effects. These translational studies are based on accumulating in vitro evidence suggesting that the activation of CD40 results in reduced proliferation and apoptosis induction selectively in cancer cells.The proposed STREP will develop vehicles for the efficient delivery of CD40L, such as CD40L-encapsulated liposome formulations and recombinant adenoviruses expressing CD40L and examine their in vitro and in vivo effects on tumour cell growth and metastasis. Apoptosis induced by CD40 engagement is dramatically augmented in the presence of inhibitors of the phosphoinositide 3-kinase (PI3 kinase) pathway which is frequently found activated in human tumours. The proposed STREP will expand on the development of inositol polyphosphates, novel PI3 kinase antagonists, and evaluate their in vitro and in vivo capacity to kill tumour cells and to amplify the CD40L-mediated effects on carcinoma cell growth, angiogenesis and metastasis. These studies will provide essential information for progressing the potential therapeutic strategy towards future clinical trials for the benefit of cancer sufferers. Dziedzina nauki medical and health sciencesclinical medicineoncologybladder cancermedical and health sciencesbasic medicinepharmacology and pharmacydrug resistance Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LSH-2005-2.2.0-2 - Modulation of apoptosis in cancer prevention and therapy Zaproszenie do składania wniosków FP6-2005-LIFESCIHEALTH-6 Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator UNIVERSITY OF CRETE Wkład UE Brak danych Adres KNOSSOU Ave.-UNIVERSITY CAMPUS 2208 HERAKLION Grecja Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (7) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko UNIVERSITY COLLEGE LONDON Zjednoczone Królestwo Wkład UE Brak danych Adres Gower Street LONDON Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych ISTITUTO DI RICERCHE FARMACOLOGICHE "MARIO NEGRI" Włochy Wkład UE Brak danych Adres Via Eritrea 62 MILANO Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych HELSINGIN YLIOPISTO Finlandia Wkład UE Brak danych Adres Yliopistonkatu 4 UNIVERSITY OF HELSINKI, HELSINKI Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERZITA PALACKEHO V OLOMOUCI Czechy Wkład UE Brak danych Adres Krizkovskeho 8 OLOMOUC Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UPPSALA UNIVERSITY Szwecja Wkład UE Brak danych Adres Sankt Olofsgatan 10B 256 UPPSALA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych NOVOSOM AG Niemcy Wkład UE Brak danych Adres Weinbergweg 22 HALLE Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych QUEEN MARY & WESTFIELD COLLEGE, UNIVERSITY OF LONDON Zjednoczone Królestwo Wkład UE Brak danych Adres MILE END ROAD LONDON Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych