Cel
A revolution in breast cancer care is likely as we move from empirical towards molecular oncology. For Europe to lead this revolution, the Breast International Group is planning a "sister" network of excellence -TRANS-BIG- dedicated to multinational translational research linked to prospective clinical trials. At the heart of TRANS-BIG is a large, non drug-oriented, molecular-based adjuvant trial for node negative patients, preceded by a validation/standardisation phase linking the genomic analysis of frozen tumour specimens to patient outcome. These exploratory and clinical studies intend, through DNA microarray gene expression, to identify patient subgroups that could be spared toxic/expensive adjuvant treatment. Such treatment tailoring for the highest incidence cancer in women might significantly decrease its economic burden. This trial aims to prospectively validate the 70-gene poor prognosis signature identified by Dutch researchers as a potentially better discriminator of outcome than traditional clinical/pathological factors. Additionally, traditional pathology analysis and bioinformatics/statistics will be centralised, contributing to standardisation/integration within the network. In light of rapidly evolving technologies, TRANS-BIG will ensure appropriate collection and storage of patient tumour/blood samples, allowing for future analysis such as proteomics and the development of user-friendly and commercially available tools in collaboration with several European SMEs. With a dedicated Ethical-Legal Committee TRANS-BIG will comply with all national/international regulations governing such research. Spreading of excellence will be achieved in partnership with Europa Donna and FECS, the latter coordinating a traineeship programme to provide opportunities for European researchers to acquire skills in breast cancer research/associated technologies.
Dziedzina nauki
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- natural sciencesbiological sciencesgeneticsDNA
- social sciencespolitical sciencespolitical transitionsrevolutions
- medical and health sciencesclinical medicineoncologybreast cancer
- medical and health sciencesbasic medicinepathology
Słowa kluczowe
Zaproszenie do składania wniosków
FP6-2002-LIFESCIHEALTH
Zobacz inne projekty w ramach tego zaproszenia
System finansowania
NoE - Network of ExcellenceKoordynator
BRUSSELS
Belgia
Zobacz na mapie
Uczestnicy (43)
AMSTERDAM
Zobacz na mapie
COPENHAGEN
Zobacz na mapie
VIENNA
Zobacz na mapie
BARCELONA
Zobacz na mapie
MADRID
Zobacz na mapie
SANTIAGO
Zobacz na mapie
NEUHERBERG
Zobacz na mapie
LONDON
Zobacz na mapie
VILLEJUIF
Zobacz na mapie
MENDRISIO (TICINO)
Zobacz na mapie
FRANKFURT / MAIN
Zobacz na mapie
ISTANBUL
Zobacz na mapie
HALLE
Zobacz na mapie
MOSCOW
Zobacz na mapie
ATHENS
Zobacz na mapie
PORTO
Zobacz na mapie
OXFORD
Zobacz na mapie
EDINBURGH
Zobacz na mapie
KÖLN
Zobacz na mapie
DUESSELDORF
Zobacz na mapie