Cel Vast amounts of money are being spent on drugs acting on membrane proteins without knowledge of the molecular details of their mode of action. Even though the genes of membrane proteins are now accessible, solving their structure remains time-consuming an d often unsuccessful. Given their physiological and biomédical importance, this constitutes a major problem in basic life sciences as well as public health care. Tools have been developed to overexpress, solubilize, stabilize, purify and crystallize membra ne proteins, and they are currently being used in large-scale initiatives for structure determination. Unfortunately, most membrane proteins resist one or more of these steps. The objective of IMPS is to develop imaginative, broad-range tools for membrane structural proteomics. The project brings together experts in chemistry, biochemistry, molecular genetics and crystallography and aims at developing original, innovative tools to attack each of these stumbling blocks. A strong core of crystallographers wit h demonstrated expertise in membrane protein structure determination will apply these novel techniques to a representative test set of membrane proteins. The approaches to be developed include original overexpression systems (insect photoreceptor cells and the chloroplast), unconventional surfactants (amphipathic polymers, fluorinated surfactants, novel detergents and additives) and unconventional crystallization systems (lipid cubic phase crystallization, other non-detergent environments, molecular scaffol ding, bicelles). These novel methodologies will be made available to the community through a distributed technological platform including workshops, hands-on training, and dissemination of the new molecules, whose large-scale synthesis and distribution wil l be carried out by a participant SME. The circulation of scientists between IMPS laboratories will guarantee the rapid spread of the new know-how. Dziedzina nauki natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesmolecular biologymolecular geneticsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesearth and related environmental sciencesgeologymineralogycrystallographynatural sciencesbiological sciencesbiochemistrybiomoleculeslipids Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Zaproszenie do składania wniosków FP6-2003-LIFESCIHEALTH-I Zobacz inne projekty w ramach tego zaproszenia System finansowania STIP - Specific Targeted Innovation Project Koordynator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Wkład UE Brak danych Adres 3, rue Michel-Ange PARIS Francja Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (6) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko MEDICAL RESEARCH COUNCIL Zjednoczone Królestwo Wkład UE Brak danych Adres 20 Park Crescent LONDON Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG Niemcy Wkład UE Brak danych Adres Seminarstr. 2 HEIDELBERG Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych TARGETING SYSTEM PHARMA Francja Wkład UE Brak danych Adres 830, chemin de Vergon EGUILLES Zobacz na mapie Koszt całkowity Brak danych UNIVERSITAET DES SAARLANDES Niemcy Wkład UE Brak danych Adres To be completed. SAARBRUECKEN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITAT KONSTANZ Niemcy Wkład UE Brak danych Adres Universitätsstr. 10 KONSTANZ Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITÉ D'AVIGNON ET DES PAYS DE VAUCLUSE Francja Wkład UE Brak danych Adres 74, rue Louis Pasteur AVIGNON Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych