Obiettivo
Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical, medical, social and health economic reasons therefore exist for improving treatment. The CENTER-TBI project will collect a prospective, contemporary, highly granular, observational dataset of 5400 patients, which will be used for better characterization of TBI and for Comparative Effectiveness Research (CER). The generalisability of our results will be reinforced by a contemporaneous registry level data collection in 15-25,000 patients. Our conceptual approach is to exploit the heterogeneity in biology, care, and outcome of TBI, to discover novel pathophysiology, refine disease characterization, and identify effective clinical interventions. Key elements are the use of emerging technologies (biomarkers, genomics and advanced MR imaging) in large numbers of patients, across the entire course of TBI (from injury to late outcome) and across all severities of injury (mild to severe). Improved characterization with these tools will aid Precision Medicine, a concept recently advocated by the US National Academy of Science, facilitating targeted management for individual patients. Our consortium includes leading experts and will bring outstanding biostatistical and neuroinformatics expertise to the project. Collaborations with external partners, other FP7 consortia, and international links within InTBIR, will greatly augment scientific resources and broaden the global scope of our research. We anticipate that the project could revolutionize our view of TBI, leading to more effective and efficient therapy, thus improving outcome and reducing costs. These outcomes reflect the goals of CER to assist consumers, clinicians, health care purchasers, and policy makers to make informed decisions, and will improve healthcare at both individual and population levels.
Campo scientifico
Invito a presentare proposte
FP7-HEALTH-2013-INNOVATION-1
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Meccanismo di finanziamento
CP-IP - Large-scale integrating projectCoordinatore
2650 Edegem
Belgio
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Partecipanti (42)
CB2 1TN Cambridge
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17177 Stockholm
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3015 GD Rotterdam
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37075 Goettingen
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918 43 Trnava
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7622 Pecs
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20520 Turku
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3012 Leuven
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75012 Paris
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20052 MONZA
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20900 MONZA
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CB10 1SA SAFFRON WALDEN
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W1B 1AL LONDON
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58455 Witten
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2333 ZA Leiden
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S10 2TN Sheffield
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4000 Liege
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80333 Muenchen
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G12 0XH Glasgow
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69120 Heidelberg
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SW7 2AZ LONDON
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02044 VTT ESPOO
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02150 Espoo
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FK9 4LA Stirling
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3400 Hillerod
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0450 Oslo
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OX3 OBP Oxford
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WD24 4QN Watford
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20122 Milano
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00014 Helsingin Yliopisto
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94607 OAKLAND CA
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32611 5500 Gainesville
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45221-0222 Cincinnati
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3800 Victoria
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1020 Auckland
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200127 SHANGHAI
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17489 Greifswald
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1080 WIEN
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10117 Berlin
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75008 Paris
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94010 BURLINGAME
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20126 MILANO
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