Obiettivo
Active therapeutic biodegradable and biocompatible materials are highly in demand. These are required for the production of medicinal products in a variety of areas including implant technology, tissue engineering, drug delivery and wound healing. Within implant technology such biomaterials can be used for dental, bone and cardiovascular implants. Tailored mechanical properties, biocompatibility and degradation rate is the key to the development for a specific implant.
Stents are tubular type implants that are deployed most commonly to recover the shape of narrowed arterial segments. Although, the clinical use of stents is widespread, they cause adverse responses including inflammation, in-stent restenosis and thrombosis. Endothelialisation of the stent greatly reduces these adverse reactions. In contrast to permanent stents there is great attraction in the notion of a biodegradable stent that recovers and maintains arterial shape and then gradually disappears and avoids further complications.
In this multi-institution & disciplinary SME focussed project we will aim to provide the technological framework that leads to the production of reinforced polymeric biomaterials tailored towards stent manufacturing without adverse effects. Both natural and synthetic polymers will be produced and used. These will be reinforced and functionalised using a variety of techniques. Controlled delivery of suitable positive additives including antimitotic factors will be aimed for and their release monitored. These highly functionalised active biomaterials will be characterised thoroughly for material properties, biocompatibility, rate of biodegradation and used for the production of ideal stents. These will be characterized thoroughly leading to preclinical validation. All required production and manufacturing guidelines will be followed.
Campo scientifico
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- medical and health sciencesmedical biotechnologytissue engineering
- natural scienceschemical sciencespolymer sciences
- engineering and technologyindustrial biotechnologybiomaterials
- medical and health sciencesmedical biotechnologyimplants
Programma(i)
Invito a presentare proposte
FP7-NMP-2013-SME-7
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Meccanismo di finanziamento
CP-TP - Collaborative Project targeted to a special group (such as SMEs)Coordinatore
ST4 7LQ STOKE ON TRENT
Regno Unito
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Partecipanti (13)
W1B 2UW London
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N91 F6PD MULLINGAR, WESTMEATH
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Partecipazione conclusa
52066 AACHEN
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BD7 IDP BRADFORD
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10129 Torino
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SO17 1BJ Southampton
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91054 Erlangen
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20600 Eibar Guipuzcoa
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80686 Munchen
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CB2 1TN Cambridge
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44801 Bochum
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10135 TORINO
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69123 Heidelberg
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