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The Role of Beta-Adrenergic Signaling in Cardiac Progenitor Cell Activation after Myocardial Infarction

Cel

Cardiovascular diseases are a leading cause of mortality in the industrialized world with myocardial infarction (MI) being one of the common pathological events. Cardiac progenitor cells (CPC) are a progenitor cell population within the myocardium and are activated after MI to proliferate, migrate to the infarct site, and participate in cardiac regeneration. CPC are a current therapeutic target to diminish cardiac injury after a MI. After a MI, the beta-adrenergic system gets activated due to excessive concentrations of catecholamines accumulating in the myocardium. Interestingly, beta-2 adrenergic signaling has been suggested to promote CPC proliferation. It is currently unknown whether resident CPC could be affected by β-adrenergic signaling therapies. We therefore propose the general hypothesis that beta2-adrenergic receptor signaling after a MI favors the activation of endogenous CPC. We will use a mouse model of MI to evaluate the activation of CPC after treatment with beta-adrenergic agonists/antagonists. CPC will be analyzed by flow cytometry and immunohistochemistry. Cardiac outcomes (infarct size and arrhythmic events) will be correlated to the activation of the CPC. We will further investigate the hypothesis that beta2-adrenergic signaling mediates CPC activation through the regulation of intracellular calcium. We will treat murine and human CPC with beta-adrenergic agonists/antagonists and examine changes in intracellular calcium flux. We will correlate the effect of beta-adrenergic signaling on CPC proliferation and migration in vitro to calcium handling. Validation of our hypothesis would begin to dissect the natural molecular signals that are an integral part of myocardial healing.

Dziedzina nauki

  • /nauki przyrodnicze/nauki chemiczne/chemia nieorganiczna/związki nieorganiczne

Zaproszenie do składania wniosków

FP7-PEOPLE-2013-IIF
Zobacz inne projekty w ramach tego zaproszenia

System finansowania

MC-IIF - International Incoming Fellowships (IIF)

Koordynator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Adres
Rue De Tolbiac 101
75654 Paris
Francja
Rodzaj działalności
Research Organisations
Wkład UE
€ 202 405,80
Kontakt administracyjny
Vincent Boyer (Mr.)