SUPERCELL proposed to develop single use fuel cells as a key component of smart and single use point-of-care devices. These microfuel cells are inspired in the lateral flow devices in terms of design, manufacturing processes and materials and take advantage of paper capillarity to keep a continuous flow of reactants. At the same time, they are conceived to follow the same life-cycle than the test strips to be powered so they can be disposed of with minimal environmental impact. These fuel cells generate energy directly from the fluid to be tested in the point-of-care device by oxidizing the molecules present in the samples. This makes possible to deliver power on-board that can be used to enable both measuring and result communicating functions. Along the project, it has been shown that it is possible to develop stand-alone paper-based power sources that operate by generating and consuming hydrogen in-situ or to extract sufficient power from blood to enable HIV detection. Besides, as the amount of power generated by the fuel cell depends on the concentration of the molecules to be oxidized, the project has also explored the viability of developing self-powered point-of-care sensors, in which the fuel cell acts both as a sensor and a power source. In particular, a glucometer that performs glucose quantification with the energy generated by a drop of serum has been successfully demonstrated. The concept has been implemented with a novel and radical minimization of electronic components that paves the way towards a new generation of devices with minimalistic electronic waste generation. The solution has the potential of being applicable to a wide variety of amperometric sensors, which will lead towards PoC digitalization at low cost as well as environmental impact. Finally, the self-powered concept has also been extended to fluid-activated paper-based batteries. The batteries have been turned into very simple ionic sensors, with promising application in wearable applications. As a demonstration, the battery has been integrated into a single use patch able to measure sweat conductivity on artificial samples. SUPERCELL has demonstrated that it is possible to break the paradigm “sensor – electronics – power source” typically used to develop a PoC device and develop a new generation of sustainable, intelligent, cost-effective and REASSURED (i.e. real-time connecte, environmentally friendly, affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free and delivered to those who need it) devices.