Complexity and dynamics of nucleic acids modifications in vivo

Project Information

dynamicmodifications

Grant agreement ID: 648879

DOI 10.3030/648879

Project closed

EC signature date 30 July 2015

Start date 1 August 2015

End date 31 May 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (18)

Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development

Author(s): Sarah Wyck; C. Herrera; Cristina E. Requena; Lilli Bittner; Petra Hajkova; Heinrich Bollwein; Raffaella Santoro
Published in: Epigenetics & Chromatin, Issue 1, 2018, ISSN 1756-8935
Publisher: BioMed Central
DOI: 10.1186/s13072-018-0224-y

Mechanistic insights into cytosine-N3 methylation by DNA methyltransferase DNMT3A

Author(s): Michael Dukatz, Cristina E Requena, Max Emperle, Petra Hajkova, Peter Sarkies, Albert Jeltsch
Published in: Journal of molecular biology, Issue 00222836, 2019, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.06.015

Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation.

Author(s): Martina Benešová; Kateřina Trejbalová; Dana Kučerová; Zdenka Vernerová; Tomáš Hron; Arpád Szabó; Rachel Amouroux; Petr Klézl; Petra Hajkova; Jiří Hejnar
Published in: Molecular Carcinogenesis, Issue 1, 2017, ISSN 1098-2744
Publisher: Wiley
DOI: 10.1002/mc.22638

Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

Author(s): Peter W. S. Hill, Harry G. Leitch, Cristina E. Requena, Zhiyi Sun, Rachel Amouroux, Monica Roman-Trufero, Malgorzata Borkowska, Jolyon Terragni, Romualdas Vaisvila, Sarah Linnett, Hakan Bagci, Gopuraja Dharmalingham, Vanja Haberle, Boris Lenhard, Yu Zheng, Sriharsa Pradhan, Petra Hajkova
Published in: Nature, Issue 555/7696, 2018, Page(s) 392-396, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature25964

De novo DNA methylation drives 5hmC accumulation in mouse zygotes

Author(s): Rachel Amouroux, Buhe Nashun, Kenjiro Shirane, Shoma Nakagawa, Peter W. S. Hill, Zelpha D’Souza, Manabu Nakayama, Masashi Matsuda, Aleksandra Turp, Elodie Ndjetehe, Vesela Encheva, Nobuaki R. Kudo, Haruhiko Koseki, Hiroyuki Sasaki, Petra Hajkova
Published in: Nature Cell Biology, Issue 18/2, 2016, Page(s) 225-233, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/ncb3296

Eggs sense high-fat diet

Author(s): Harry G. Leitch, Petra Hajkova
Published in: Nature Genetics, 2018, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-018-0068-1

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation

Author(s): Laure Ferry, Alexandra Fournier, Takeshi Tsusaka, Guillaume Adelmant, Tadahiro Shimazu, Shohei Matano, Olivier Kirsh, Rachel Amouroux, Naoshi Dohmae, Takehiro Suzuki, Guillaume J. Filion, Wen Deng, Maud de Dieuleveult, Lauriane Fritsch, Srikanth Kudithipudi, Albert Jeltsch, Heinrich Leonhardt, Petra Hajkova, Jarrod A. Marto, Kyohei Arita, Yoichi Shinkai, Pierre-Antoine Defossez
Published in: Molecular Cell, Issue 67/4, 2017, Page(s) 550-565.e5, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2017.07.012

Dynamic changes in H1 subtype composition during epigenetic reprogramming

Author(s): Annalisa Izzo, Céline Ziegler-Birling, Peter W.S. Hill, Lydia Brondani, Petra Hajkova, Maria-Elena Torres-Padilla, Robert Schneider
Published in: The Journal of Cell Biology, Issue 216/10, 2017, Page(s) 3017-3028, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201611012

Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity

Author(s): Silvana Rošić, Rachel Amouroux, Cristina E. Requena, Ana Gomes, Max Emperle, Toni Beltran, Jayant K. Rane, Sarah Linnett, Murray E. Selkirk, Philipp H. Schiffer, Allison J. Bancroft, Richard K. Grencis, Albert Jeltsch, Petra Hajkova, Peter Sarkies
Published in: Nature Genetics, 2018, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-018-0061-8

DNA (De)Methylation: The Passive Route to Naïvety?

Author(s): Harry G. Leitch, M. Azim Surani, Petra Hajkova
Published in: Trends in Genetics, Issue 32/10, 2016, Page(s) 592-595, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2016.08.005

Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase

Author(s): Sandra Catania, Phillip A Dumesic, Harold Pimentel, Ammar Nasif, Caitlin I Stoddard, Jordan E Burke, Jolene K Diedrich, Sophie Cooke, Terrance Shea, Elizabeth Gienger, Robert Lintner, John R Yates III, Petra Hajkova, Geeta J Narlikar, Christina A Cuomo, Jonathan K Pritchard, Hiten D Madhani
Published in: Cell, 2020, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.12.012

Dynamic DNA methylation: In the right place at the right time

Author(s): Chongyuan Luo; Petra Hajkova; Joseph R. Ecker
Published in: Science, Issue 00368075, 2018, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aat6806

Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes

Author(s): Linn Gillberg, Andreas D Ørskov, Ammar Nasif, Hitoshi Ohtani, Zachary Madaj, Jakob W Hansen, Nicolas Rapin, Johanne B Mogensen, Minmin Liu, Inge H Dufva, Jens Lykkesfeldt, Petra Hajkova, Peter A Jones, Kirsten Grønbæk
Published in: Clinical epigenetics, Issue 18687075, 2019, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-019-0739-5

SLIC-CAGE: high-resolution transcription start site mapping using nanogram-levels of total RNA.

Author(s): Nevena Cvetesic; Harry G. Leitch; Malgorzata Borkowska; Ferenc Müller; Piero Carninci; Petra Hajkova; Boris Lenhard; Boris Lenhard
Published in: Genome Research, Issue 1, 2018, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.235937.118

TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage

Author(s): Changwei Yu, Nevena Cvetesic, Vincent Hisler, Kapil Gupta, Tao Ye, Emese Gazdag, Luc Negroni, Petra Hajkova, Imre Berger, Boris Lenhard, Ferenc Müller, Stéphane D Vincent, László Tora
Published in: Nature communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20239-4

Sex-specific chromatin remodelling safeguards transcription in germ cells.

Author(s): Tien-Chi Huang, Yi-Fang Wang, Eric Vazquez-Ferrer, Ina Theofel, Cristina E. Requena, Courtney W. Hanna, Gavin Kelsey & Petra Hajkova
Published in: Nature, 2021, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-04208-5

Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage

Author(s): Qifan Zhu, Fei Sang, Sarah Withey, Walfred Tang, Sabine Dietmann, Doris Klisch, Priscila Ramos-Ibeas, Haixin Zhang, Cristina E Requena, Petra Hajkova, Matt Loose, M Azim Surani, Ramiro Alberio
Published in: Cell Reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.108735

TET2 Regulates the Neuroinflammatory Response in Microglia

Author(s): Alejandro Carrillo-Jimenez, Özgen Deniz, Maria Victoria Niklison-Chirou, Rocio Ruiz, Karina Bezerra-Salomao, Vassilis Stratoulias, Rachel Amouroux, Ping Kei Yip, Anna Vilalta, Mathilde Cheray, Alexander Michael Scott-Egerton, Eloy Rivas, Khadija Tayara, Irene García-Domínguez, Juan Garcia-Revilla, Juan Carlos Fernandez-Martin, Ana Maria Espinosa-Oliva, Xianli Shen, Peter St George-Hyslop, Guy C
Published in: Cell Reports, Issue 22111247, 2019, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.09.013

Other (1)

Global regulatory transitions at core promoters demarcate the mammalian germline cycle

Author(s): Nevena Cvetesic; Malgorzata Borkowska; Yuki Hatanaka; Harry G. Leitch; Ferenc Müller; Changwei Yu; Stéphane D. Vincent; Laszlo Tora; Petra Hajkova; Boris Lenhard
Published in: BioRxiv, 2020
Publisher: Cold Spring Harbour Laboratory
DOI: 10.1101/2020.10.30.361865