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Complexity and dynamics of nucleic acids modifications in vivo

Publications

Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

Author(s): Peter W. S. Hill, Harry G. Leitch, Cristina E. Requena, Zhiyi Sun, Rachel Amouroux, Monica Roman-Trufero, Malgorzata Borkowska, Jolyon Terragni, Romualdas Vaisvila, Sarah Linnett, Hakan Bagci, Gopuraja Dharmalingham, Vanja Haberle, Boris Lenhard, Yu Zheng, Sriharsa Pradhan, Petra Hajkova
Published in: Nature, Issue 555/7696, 2018, Page(s) 392-396, ISSN 0028-0836
DOI: 10.1038/nature25964

De novo DNA methylation drives 5hmC accumulation in mouse zygotes

Author(s): Rachel Amouroux, Buhe Nashun, Kenjiro Shirane, Shoma Nakagawa, Peter W. S. Hill, Zelpha D’Souza, Manabu Nakayama, Masashi Matsuda, Aleksandra Turp, Elodie Ndjetehe, Vesela Encheva, Nobuaki R. Kudo, Haruhiko Koseki, Hiroyuki Sasaki, Petra Hajkova
Published in: Nature Cell Biology, Issue 18/2, 2016, Page(s) 225-233, ISSN 1465-7392
DOI: 10.1038/ncb3296

Eggs sense high-fat diet

Author(s): Harry G. Leitch, Petra Hajkova
Published in: Nature Genetics, 2018, ISSN 1061-4036
DOI: 10.1038/s41588-018-0068-1

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation

Author(s): Laure Ferry, Alexandra Fournier, Takeshi Tsusaka, Guillaume Adelmant, Tadahiro Shimazu, Shohei Matano, Olivier Kirsh, Rachel Amouroux, Naoshi Dohmae, Takehiro Suzuki, Guillaume J. Filion, Wen Deng, Maud de Dieuleveult, Lauriane Fritsch, Srikanth Kudithipudi, Albert Jeltsch, Heinrich Leonhardt, Petra Hajkova, Jarrod A. Marto, Kyohei Arita, Yoichi Shinkai, Pierre-Antoine Defossez
Published in: Molecular Cell, Issue 67/4, 2017, Page(s) 550-565.e5, ISSN 1097-2765
DOI: 10.1016/j.molcel.2017.07.012

Dynamic changes in H1 subtype composition during epigenetic reprogramming

Author(s): Annalisa Izzo, Céline Ziegler-Birling, Peter W.S. Hill, Lydia Brondani, Petra Hajkova, Maria-Elena Torres-Padilla, Robert Schneider
Published in: The Journal of Cell Biology, Issue 216/10, 2017, Page(s) 3017-3028, ISSN 0021-9525
DOI: 10.1083/jcb.201611012

Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity

Author(s): Silvana Rošić, Rachel Amouroux, Cristina E. Requena, Ana Gomes, Max Emperle, Toni Beltran, Jayant K. Rane, Sarah Linnett, Murray E. Selkirk, Philipp H. Schiffer, Allison J. Bancroft, Richard K. Grencis, Albert Jeltsch, Petra Hajkova, Peter Sarkies
Published in: Nature Genetics, 2018, ISSN 1061-4036
DOI: 10.1038/s41588-018-0061-8

DNA (De)Methylation: The Passive Route to Naïvety?

Author(s): Harry G. Leitch, M. Azim Surani, Petra Hajkova
Published in: Trends in Genetics, Issue 32/10, 2016, Page(s) 592-595, ISSN 0168-9525
DOI: 10.1016/j.tig.2016.08.005