Complexity and dynamics of nucleic acids modifications in vivo

Información del proyecto

dynamicmodifications

Identificador del acuerdo de subvención: 648879

DOI

10.3030/648879

Proyecto cerrado

Fecha de la firma de la CE 30 Julio 2015

Fecha de inicio 1 Agosto 2015

Fecha de finalización 31 Mayo 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 000 000,00

Aportación de la UE

€ 2 000 000,00

Coordinado por

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (18)

Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development

Autores: Sarah Wyck; C. Herrera; Cristina E. Requena; Lilli Bittner; Petra Hajkova; Heinrich Bollwein; Raffaella Santoro
Publicado en: Epigenetics & Chromatin, Edición 1, 2018, ISSN 1756-8935
Editor: BioMed Central
DOI: 10.1186/s13072-018-0224-y

Mechanistic insights into cytosine-N3 methylation by DNA methyltransferase DNMT3A

Autores: Michael Dukatz, Cristina E Requena, Max Emperle, Petra Hajkova, Peter Sarkies, Albert Jeltsch
Publicado en: Journal of molecular biology, Edición 00222836, 2019, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2019.06.015

Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation.

Autores: Martina Benešová; Kateřina Trejbalová; Dana Kučerová; Zdenka Vernerová; Tomáš Hron; Arpád Szabó; Rachel Amouroux; Petr Klézl; Petra Hajkova; Jiří Hejnar
Publicado en: Molecular Carcinogenesis, Edición 1, 2017, ISSN 1098-2744
Editor: Wiley
DOI: 10.1002/mc.22638

Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

Autores: Peter W. S. Hill, Harry G. Leitch, Cristina E. Requena, Zhiyi Sun, Rachel Amouroux, Monica Roman-Trufero, Malgorzata Borkowska, Jolyon Terragni, Romualdas Vaisvila, Sarah Linnett, Hakan Bagci, Gopuraja Dharmalingham, Vanja Haberle, Boris Lenhard, Yu Zheng, Sriharsa Pradhan, Petra Hajkova
Publicado en: Nature, Edición 555/7696, 2018, Página(s) 392-396, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature25964

De novo DNA methylation drives 5hmC accumulation in mouse zygotes

Autores: Rachel Amouroux, Buhe Nashun, Kenjiro Shirane, Shoma Nakagawa, Peter W. S. Hill, Zelpha D’Souza, Manabu Nakayama, Masashi Matsuda, Aleksandra Turp, Elodie Ndjetehe, Vesela Encheva, Nobuaki R. Kudo, Haruhiko Koseki, Hiroyuki Sasaki, Petra Hajkova
Publicado en: Nature Cell Biology, Edición 18/2, 2016, Página(s) 225-233, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/ncb3296

Eggs sense high-fat diet

Autores: Harry G. Leitch, Petra Hajkova
Publicado en: Nature Genetics, 2018, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-018-0068-1

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation

Autores: Laure Ferry, Alexandra Fournier, Takeshi Tsusaka, Guillaume Adelmant, Tadahiro Shimazu, Shohei Matano, Olivier Kirsh, Rachel Amouroux, Naoshi Dohmae, Takehiro Suzuki, Guillaume J. Filion, Wen Deng, Maud de Dieuleveult, Lauriane Fritsch, Srikanth Kudithipudi, Albert Jeltsch, Heinrich Leonhardt, Petra Hajkova, Jarrod A. Marto, Kyohei Arita, Yoichi Shinkai, Pierre-Antoine Defossez
Publicado en: Molecular Cell, Edición 67/4, 2017, Página(s) 550-565.e5, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2017.07.012

Dynamic changes in H1 subtype composition during epigenetic reprogramming

Autores: Annalisa Izzo, Céline Ziegler-Birling, Peter W.S. Hill, Lydia Brondani, Petra Hajkova, Maria-Elena Torres-Padilla, Robert Schneider
Publicado en: The Journal of Cell Biology, Edición 216/10, 2017, Página(s) 3017-3028, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.201611012

Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity

Autores: Silvana Rošić, Rachel Amouroux, Cristina E. Requena, Ana Gomes, Max Emperle, Toni Beltran, Jayant K. Rane, Sarah Linnett, Murray E. Selkirk, Philipp H. Schiffer, Allison J. Bancroft, Richard K. Grencis, Albert Jeltsch, Petra Hajkova, Peter Sarkies
Publicado en: Nature Genetics, 2018, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-018-0061-8

DNA (De)Methylation: The Passive Route to Naïvety?

Autores: Harry G. Leitch, M. Azim Surani, Petra Hajkova
Publicado en: Trends in Genetics, Edición 32/10, 2016, Página(s) 592-595, ISSN 0168-9525
Editor: Elsevier BV
DOI: 10.1016/j.tig.2016.08.005

Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase

Autores: Sandra Catania, Phillip A Dumesic, Harold Pimentel, Ammar Nasif, Caitlin I Stoddard, Jordan E Burke, Jolene K Diedrich, Sophie Cooke, Terrance Shea, Elizabeth Gienger, Robert Lintner, John R Yates III, Petra Hajkova, Geeta J Narlikar, Christina A Cuomo, Jonathan K Pritchard, Hiten D Madhani
Publicado en: Cell, 2020, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2019.12.012

Dynamic DNA methylation: In the right place at the right time

Autores: Chongyuan Luo; Petra Hajkova; Joseph R. Ecker
Publicado en: Science, Edición 00368075, 2018, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aat6806

Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes

Autores: Linn Gillberg, Andreas D Ørskov, Ammar Nasif, Hitoshi Ohtani, Zachary Madaj, Jakob W Hansen, Nicolas Rapin, Johanne B Mogensen, Minmin Liu, Inge H Dufva, Jens Lykkesfeldt, Petra Hajkova, Peter A Jones, Kirsten Grønbæk
Publicado en: Clinical epigenetics, 2019, ISSN 1868-7075
Editor: Springer Verlag
DOI: 10.1186/s13148-019-0739-5

SLIC-CAGE: high-resolution transcription start site mapping using nanogram-levels of total RNA.

Autores: Nevena Cvetesic; Harry G. Leitch; Malgorzata Borkowska; Ferenc Müller; Piero Carninci; Petra Hajkova; Boris Lenhard; Boris Lenhard
Publicado en: Genome Research, Edición 1, 2018, ISSN 1088-9051
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.235937.118

TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage

Autores: Changwei Yu, Nevena Cvetesic, Vincent Hisler, Kapil Gupta, Tao Ye, Emese Gazdag, Luc Negroni, Petra Hajkova, Imre Berger, Boris Lenhard, Ferenc Müller, Stéphane D Vincent, László Tora
Publicado en: Nature communications, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-20239-4

Sex-specific chromatin remodelling safeguards transcription in germ cells.

Autores: Tien-Chi Huang, Yi-Fang Wang, Eric Vazquez-Ferrer, Ina Theofel, Cristina E. Requena, Courtney W. Hanna, Gavin Kelsey & Petra Hajkova
Publicado en: Nature, 2021, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-021-04208-5

Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage

Autores: Qifan Zhu, Fei Sang, Sarah Withey, Walfred Tang, Sabine Dietmann, Doris Klisch, Priscila Ramos-Ibeas, Haixin Zhang, Cristina E Requena, Petra Hajkova, Matt Loose, M Azim Surani, Ramiro Alberio
Publicado en: Cell Reports, 2021, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.108735

TET2 Regulates the Neuroinflammatory Response in Microglia

Autores: Alejandro Carrillo-Jimenez, Özgen Deniz, Maria Victoria Niklison-Chirou, Rocio Ruiz, Karina Bezerra-Salomao, Vassilis Stratoulias, Rachel Amouroux, Ping Kei Yip, Anna Vilalta, Mathilde Cheray, Alexander Michael Scott-Egerton, Eloy Rivas, Khadija Tayara, Irene García-Domínguez, Juan Garcia-Revilla, Juan Carlos Fernandez-Martin, Ana Maria Espinosa-Oliva, Xianli Shen, Peter St George-Hyslop, Guy C
Publicado en: Cell Reports, 2019, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.09.013

Other (1)

Global regulatory transitions at core promoters demarcate the mammalian germline cycle

Autores: Nevena Cvetesic; Malgorzata Borkowska; Yuki Hatanaka; Harry G. Leitch; Ferenc Müller; Changwei Yu; Stéphane D. Vincent; Laszlo Tora; Petra Hajkova; Boris Lenhard
Publicado en: BioRxiv, 2020
Editor: Cold Spring Harbour Laboratory
DOI: 10.1101/2020.10.30.361865