Complexity and dynamics of nucleic acids modifications in vivo

Informazioni relative al progetto

dynamicmodifications

ID dell’accordo di sovvenzione: 648879

DOI

10.3030/648879

Progetto chiuso

Data della firma CE 30 Luglio 2015

Data di avvio 1 Agosto 2015

Data di completamento 31 Maggio 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 000 000,00

Contributo UE

€ 2 000 000,00

Coordinato da

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (18)

Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development

Autori: Sarah Wyck; C. Herrera; Cristina E. Requena; Lilli Bittner; Petra Hajkova; Heinrich Bollwein; Raffaella Santoro
Pubblicato in: Epigenetics & Chromatin, Numero 1, 2018, ISSN 1756-8935
Editore: BioMed Central
DOI: 10.1186/s13072-018-0224-y

Mechanistic insights into cytosine-N3 methylation by DNA methyltransferase DNMT3A

Autori: Michael Dukatz, Cristina E Requena, Max Emperle, Petra Hajkova, Peter Sarkies, Albert Jeltsch
Pubblicato in: Journal of molecular biology, Numero 00222836, 2019, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2019.06.015

Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation.

Autori: Martina Benešová; Kateřina Trejbalová; Dana Kučerová; Zdenka Vernerová; Tomáš Hron; Arpád Szabó; Rachel Amouroux; Petr Klézl; Petra Hajkova; Jiří Hejnar
Pubblicato in: Molecular Carcinogenesis, Numero 1, 2017, ISSN 1098-2744
Editore: Wiley
DOI: 10.1002/mc.22638

Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

Autori: Peter W. S. Hill, Harry G. Leitch, Cristina E. Requena, Zhiyi Sun, Rachel Amouroux, Monica Roman-Trufero, Malgorzata Borkowska, Jolyon Terragni, Romualdas Vaisvila, Sarah Linnett, Hakan Bagci, Gopuraja Dharmalingham, Vanja Haberle, Boris Lenhard, Yu Zheng, Sriharsa Pradhan, Petra Hajkova
Pubblicato in: Nature, Numero 555/7696, 2018, Pagina/e 392-396, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/nature25964

De novo DNA methylation drives 5hmC accumulation in mouse zygotes

Autori: Rachel Amouroux, Buhe Nashun, Kenjiro Shirane, Shoma Nakagawa, Peter W. S. Hill, Zelpha D’Souza, Manabu Nakayama, Masashi Matsuda, Aleksandra Turp, Elodie Ndjetehe, Vesela Encheva, Nobuaki R. Kudo, Haruhiko Koseki, Hiroyuki Sasaki, Petra Hajkova
Pubblicato in: Nature Cell Biology, Numero 18/2, 2016, Pagina/e 225-233, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/ncb3296

Eggs sense high-fat diet

Autori: Harry G. Leitch, Petra Hajkova
Pubblicato in: Nature Genetics, 2018, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-018-0068-1

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation

Autori: Laure Ferry, Alexandra Fournier, Takeshi Tsusaka, Guillaume Adelmant, Tadahiro Shimazu, Shohei Matano, Olivier Kirsh, Rachel Amouroux, Naoshi Dohmae, Takehiro Suzuki, Guillaume J. Filion, Wen Deng, Maud de Dieuleveult, Lauriane Fritsch, Srikanth Kudithipudi, Albert Jeltsch, Heinrich Leonhardt, Petra Hajkova, Jarrod A. Marto, Kyohei Arita, Yoichi Shinkai, Pierre-Antoine Defossez
Pubblicato in: Molecular Cell, Numero 67/4, 2017, Pagina/e 550-565.e5, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2017.07.012

Dynamic changes in H1 subtype composition during epigenetic reprogramming

Autori: Annalisa Izzo, Céline Ziegler-Birling, Peter W.S. Hill, Lydia Brondani, Petra Hajkova, Maria-Elena Torres-Padilla, Robert Schneider
Pubblicato in: The Journal of Cell Biology, Numero 216/10, 2017, Pagina/e 3017-3028, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.201611012

Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity

Autori: Silvana Rošić, Rachel Amouroux, Cristina E. Requena, Ana Gomes, Max Emperle, Toni Beltran, Jayant K. Rane, Sarah Linnett, Murray E. Selkirk, Philipp H. Schiffer, Allison J. Bancroft, Richard K. Grencis, Albert Jeltsch, Petra Hajkova, Peter Sarkies
Pubblicato in: Nature Genetics, 2018, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-018-0061-8

DNA (De)Methylation: The Passive Route to Naïvety?

Autori: Harry G. Leitch, M. Azim Surani, Petra Hajkova
Pubblicato in: Trends in Genetics, Numero 32/10, 2016, Pagina/e 592-595, ISSN 0168-9525
Editore: Elsevier BV
DOI: 10.1016/j.tig.2016.08.005

Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase

Autori: Sandra Catania, Phillip A Dumesic, Harold Pimentel, Ammar Nasif, Caitlin I Stoddard, Jordan E Burke, Jolene K Diedrich, Sophie Cooke, Terrance Shea, Elizabeth Gienger, Robert Lintner, John R Yates III, Petra Hajkova, Geeta J Narlikar, Christina A Cuomo, Jonathan K Pritchard, Hiten D Madhani
Pubblicato in: Cell, 2020, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2019.12.012

Dynamic DNA methylation: In the right place at the right time

Autori: Chongyuan Luo; Petra Hajkova; Joseph R. Ecker
Pubblicato in: Science, Numero 00368075, 2018, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aat6806

Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes

Autori: Linn Gillberg, Andreas D Ørskov, Ammar Nasif, Hitoshi Ohtani, Zachary Madaj, Jakob W Hansen, Nicolas Rapin, Johanne B Mogensen, Minmin Liu, Inge H Dufva, Jens Lykkesfeldt, Petra Hajkova, Peter A Jones, Kirsten Grønbæk
Pubblicato in: Clinical epigenetics, 2019, ISSN 1868-7075
Editore: Springer Verlag
DOI: 10.1186/s13148-019-0739-5

SLIC-CAGE: high-resolution transcription start site mapping using nanogram-levels of total RNA.

Autori: Nevena Cvetesic; Harry G. Leitch; Malgorzata Borkowska; Ferenc Müller; Piero Carninci; Petra Hajkova; Boris Lenhard; Boris Lenhard
Pubblicato in: Genome Research, Numero 1, 2018, ISSN 1088-9051
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.235937.118

TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage

Autori: Changwei Yu, Nevena Cvetesic, Vincent Hisler, Kapil Gupta, Tao Ye, Emese Gazdag, Luc Negroni, Petra Hajkova, Imre Berger, Boris Lenhard, Ferenc Müller, Stéphane D Vincent, László Tora
Pubblicato in: Nature communications, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-20239-4

Sex-specific chromatin remodelling safeguards transcription in germ cells.

Autori: Tien-Chi Huang, Yi-Fang Wang, Eric Vazquez-Ferrer, Ina Theofel, Cristina E. Requena, Courtney W. Hanna, Gavin Kelsey & Petra Hajkova
Pubblicato in: Nature, 2021, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-04208-5

Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage

Autori: Qifan Zhu, Fei Sang, Sarah Withey, Walfred Tang, Sabine Dietmann, Doris Klisch, Priscila Ramos-Ibeas, Haixin Zhang, Cristina E Requena, Petra Hajkova, Matt Loose, M Azim Surani, Ramiro Alberio
Pubblicato in: Cell Reports, 2021, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.108735

TET2 Regulates the Neuroinflammatory Response in Microglia

Autori: Alejandro Carrillo-Jimenez, Özgen Deniz, Maria Victoria Niklison-Chirou, Rocio Ruiz, Karina Bezerra-Salomao, Vassilis Stratoulias, Rachel Amouroux, Ping Kei Yip, Anna Vilalta, Mathilde Cheray, Alexander Michael Scott-Egerton, Eloy Rivas, Khadija Tayara, Irene García-Domínguez, Juan Garcia-Revilla, Juan Carlos Fernandez-Martin, Ana Maria Espinosa-Oliva, Xianli Shen, Peter St George-Hyslop, Guy C
Pubblicato in: Cell Reports, 2019, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.09.013

Other (1)

Global regulatory transitions at core promoters demarcate the mammalian germline cycle

Autori: Nevena Cvetesic; Malgorzata Borkowska; Yuki Hatanaka; Harry G. Leitch; Ferenc Müller; Changwei Yu; Stéphane D. Vincent; Laszlo Tora; Petra Hajkova; Boris Lenhard
Pubblicato in: BioRxiv, 2020
Editore: Cold Spring Harbour Laboratory
DOI: 10.1101/2020.10.30.361865