Descripción del proyecto
El ictus y la enfermedad de Alzheimer: ¿compañeros de fechorías?
Hace tiempo que se reconoce la coexistencia del ictus y la enfermedad de Alzheimer (EA), lo que sugiere la presencia de causas y mecanismos similares. Dado que una proporción significativa de supervivientes de ictus desarrollan demencia y que muchos ancianos con la EA sufren ictus, es necesario comprender la conexión y los orígenes de estos trastornos. El equipo del proyecto CoSTREAM, financiado con fondos europeos, pretende colmar esta laguna de conocimientos y arrojar luz sobre la relación entre el ictus y la EA. Los investigadores estudiarán vías comunes, con la esperanza de identificar nuevos biomarcadores de la naturaleza interrelacionada de estos trastornos. Los resultados mejorarán las estrategias de prevención y tratamiento de los pacientes.
Objetivo
Common mechanisms and pathways in Stroke and Alzheimer's disease.
It has long been recognized that stroke and (Alzheimer’s Disease) AD often co-occur and have an overlapping pathogenesis. As such, these two diseases are not considered fellow travelers, but rather partners in crime. This multidisciplinary consortium includes epidemiologists, geneticists, radiologists, neurologists with a longstanding track-record on the etiology of stroke and AD.
This project aims to improve our understanding of the co-occurrence of stroke and AD. An essential concept of our proposal is that stroke and AD are sequential diseases that have overlapping pathyphysiological mechanisms in addition to shared risk factors. We will particularly focus on these common mechanisms and disentangle when and how these mechanisms diverge into causing either stroke, or AD, or both. Another important concept is that mechanisms under study will not only include the known pathways of ischemic vasculopathy and CAA, but we will explore and unravel novel mechanisms linking stroke and AD. We will do so by exploiting our vast international network in order to link various big datasets and by incorporating novel analytical strategies with emerging technologies in the field of genomics, metabolomics, and brain MR-imaging.
Ámbito científico
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- medical and health scienceshealth sciencespersonalized medicine
- medical and health sciencesbasic medicineneurologystroke
Palabras clave
Programa(s)
Tema(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-PHC-2015-two-stage
Régimen de financiación
RIA - Research and Innovation actionCoordinador
3015 GD Rotterdam
Países Bajos