Description du projet
Accident vasculaire cérébral et maladie d’Alzheimer: complices du crime?
La cooccurrence des accidents vasculaires cérébraux et de la maladie d’Alzheimer (MA) est reconnue depuis longtemps, et suggère la présence de causes et de mécanismes similaires. Étant donné qu’une proportion importante de personnes ayant survécu à un accident vasculaire cérébral développent une forme de démence et que de nombreuses personnes âgées atteintes de la maladie d’Alzheimer sont victimes d’un accident vasculaire cérébral, il est primordial de comprendre le lien et l’origine de ces troubles. Le projet CoSTREAM, financé par l’UE, entend combler ce manque de connaissances et faire la lumière sur la relation entre l’accident vasculaire cérébral et la maladie d’Alzheimer. Les chercheurs étudieront leurs voies communes, dans l’espoir d’identifier de nouveaux biomarqueurs de la nature interdépendante de ces troubles. Les résultats permettront d’améliorer les stratégies de prévention et de traitement des patients.
Objectif
Common mechanisms and pathways in Stroke and Alzheimer's disease.
It has long been recognized that stroke and (Alzheimer’s Disease) AD often co-occur and have an overlapping pathogenesis. As such, these two diseases are not considered fellow travelers, but rather partners in crime. This multidisciplinary consortium includes epidemiologists, geneticists, radiologists, neurologists with a longstanding track-record on the etiology of stroke and AD.
This project aims to improve our understanding of the co-occurrence of stroke and AD. An essential concept of our proposal is that stroke and AD are sequential diseases that have overlapping pathyphysiological mechanisms in addition to shared risk factors. We will particularly focus on these common mechanisms and disentangle when and how these mechanisms diverge into causing either stroke, or AD, or both. Another important concept is that mechanisms under study will not only include the known pathways of ischemic vasculopathy and CAA, but we will explore and unravel novel mechanisms linking stroke and AD. We will do so by exploiting our vast international network in order to link various big datasets and by incorporating novel analytical strategies with emerging technologies in the field of genomics, metabolomics, and brain MR-imaging.
Champ scientifique
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- medical and health scienceshealth sciencespersonalized medicine
- medical and health sciencesbasic medicineneurologystroke
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RIA - Research and Innovation actionCoordinateur
3015 GD Rotterdam
Pays-Bas