Descrizione del progetto
Ictus e malattia di Alzheimer sono complici?
La co-occorrenza di ictus e malattia di Alzheimer è stata riconosciuta da tempo, suggerendo la presenza di cause e meccanismi simili. Poiché una percentuale significativa di persone sopravvissute a un ictus sviluppa una demenza e molti individui anziani affetti da malattia di Alzheimer subiscono un ictus, è necessario comprendere la connessione e le origini di questi disturbi. Il progetto CoSTREAM, finanziato dall’UE, mira a colmare questa lacuna di conoscenze e a far luce sul rapporto tra ictus e malattia di Alzheimer. I ricercatori studieranno le vie comuni, sperando di identificare nuovi biomarcatori per la natura interconnessa di questi disturbi. I risultati miglioreranno le strategie di prevenzione e trattamento dei pazienti.
Obiettivo
Common mechanisms and pathways in Stroke and Alzheimer's disease.
It has long been recognized that stroke and (Alzheimer’s Disease) AD often co-occur and have an overlapping pathogenesis. As such, these two diseases are not considered fellow travelers, but rather partners in crime. This multidisciplinary consortium includes epidemiologists, geneticists, radiologists, neurologists with a longstanding track-record on the etiology of stroke and AD.
This project aims to improve our understanding of the co-occurrence of stroke and AD. An essential concept of our proposal is that stroke and AD are sequential diseases that have overlapping pathyphysiological mechanisms in addition to shared risk factors. We will particularly focus on these common mechanisms and disentangle when and how these mechanisms diverge into causing either stroke, or AD, or both. Another important concept is that mechanisms under study will not only include the known pathways of ischemic vasculopathy and CAA, but we will explore and unravel novel mechanisms linking stroke and AD. We will do so by exploiting our vast international network in order to link various big datasets and by incorporating novel analytical strategies with emerging technologies in the field of genomics, metabolomics, and brain MR-imaging.
Campo scientifico
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- medical and health scienceshealth sciencespersonalized medicine
- medical and health sciencesbasic medicineneurologystroke
Parole chiave
Programma(i)
Argomento(i)
Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-PHC-2015-two-stage
Meccanismo di finanziamento
RIA - Research and Innovation actionCoordinatore
3015 GD Rotterdam
Paesi Bassi