Resolution Pharmacology and Physiology of MCTR in Arthritis

Informazioni relative al progetto

MCTRinIA

ID dell’accordo di sovvenzione: 677542

DOI 10.3030/677542

Progetto chiuso

Data della firma CE 4 Marzo 2016

Data di avvio 1 Marzo 2016

Data di completamento 31 Agosto 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 964 303,00

Contributo UE € 1 964 303,00

Coordinato da

QUEEN MARY UNIVERSITY OF LONDON
United Kingdom

Pubblicazioni

Peer reviewed articles (31)

GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections

Autori: Magdalena B. Flak, Duco S. Koenis, Agua Sobrino, James Smith, Kimberly Pistorius, Francesco Palmas, Jesmond Dalli
Pubblicato in: Journal of Clinical Investigation, Numero 130/1, 2020, Pagina/e 359-373, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci131609

Protective activities of distinct omega-3 enriched oils are linked to their ability to upregulate specialized pro-resolving mediators

Autori: Agua Sobrino, Mary E. Walker, Romain A. Colas, Jesmond Dalli
Pubblicato in: PLOS ONE, Numero 15/12, 2020, Pagina/e e0242543, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0242543

15‐Epi‐Lxa 4 and MaR1 counter inflammation in stromal cells from patients with Achilles tendinopathy and rupture

Autori: Stephanie G. Dakin, Romain A. Colas, Julia Newton, Stephen Gwilym, Natasha Jones, Hamish A. B. Reid, Simon Wood, Louise Appleton, Kim Wheway, Bridget Watkins, Jesmond Dalli, Andrew J. Carr
Pubblicato in: The FASEB Journal, Numero 33/7, 2019, Pagina/e 8043-8054, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201900196R

Dysregulated Maresin Concentrations in Plasma and Nasal Secretions From Patients With Chronic Rhinosinusitis

Autori: Issa Beegun, Duco S. Koenis, Ghassan Alusi, Jesmond Dalli
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2021.733019

Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis.

Autori: Flak, Magdalena B.; Colas, Romain A.; Muñoz-Atienza, Estefanía; Curtis, Michael A.; Dalli, Jesmond; Pitzalis, Costantino
Pubblicato in: The Journal of Clinical Investigations Insights, Numero 3, 2019, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.125191

Synthesis, Structural Confirmation, and Biosynthesis of 22-OH-PD1n-3 DPA

Autori: Jannicke Irina Nesman, Karoline Gangestad Primdahl, Jørn Eivind Tungen, Fransesco Palmas, Jesmond Dalli, Trond Vidar Hansen
Pubblicato in: Molecules, Numero 24/18, 2019, Pagina/e 3228, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24183228

Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs

Autori: David M. Sokal, Alex McSloy, Matteo Donegà, Joseph Kirk, Romain A. Colas, Nikola Dolezalova, Esteban A. Gomez, Isha Gupta, Cathrine T. Fjordbakk, Sebastien Ouchouche, Paul B. Matteucci, Kristina Schlegel, Rizwan Bashirullah, Dirk Werling, Kim Harman, Alison Rowles, Refet Firat Yazicioglu, Jesmond Dalli, Daniel J. Chew, Justin D. Perkins
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2021.649786

Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction

Autori: Linn E. Fosshaug, Romain A. Colas, Anne K. Anstensrud, Ida Gregersen, Ståle Nymo, Ellen L. Sagen, Annika Michelsen, Leif E. Vinge, Erik Øie, Lars Gullestad, Bente Halvorsen, Trond V. Hansen, Pål Aukrust, Jesmond Dalli, Arne Yndestad
Pubblicato in: EBioMedicine, Numero 46, 2019, Pagina/e 264-273, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2019.07.024

Dysregulated plasma lipid mediator profiles in critically ill COVID-19 patients

Autori: Francesco Palmas, Jennifer Clarke, Romain A. Colas, Esteban A. Gomez, Aoife Keogh, Maria Boylan, Natalie McEvoy, Oliver J. McElvaney, Oisin McElvaney, Razi Alalqam, Noel G. McElvaney, Gerard F. Curley, Jesmond Dalli
Pubblicato in: PLOS ONE, Numero 16/8, 2021, Pagina/e e0256226, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0256226

n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis

Autori: Federica Frigerio, Giulia Pasqualini, Ilaria Craparotta, Sergio Marchini, Erwin A van Vliet, Patrick Foerch, Catherine Vandenplas, Karin Leclercq, Eleonora Aronica, Luca Porcu, Kimberly Pistorius, Romain A Colas, Trond V Hansen, Mauro Perretti, Rafal M Kaminski, Jesmond Dalli, Annamaria Vezzani
Pubblicato in: Brain, 2018, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awy247

Proresolving mediator profiles in cerebrospinal fluid are linked with disease severity and outcome in adults with tuberculous meningitis

Autori: Romain A. Colas, Le Thanh Hoang Nhat, Nguyen Thuy Thuong Thuong, Esteban A. Gómez, Lucy Ly, Hai Hoang Thanh, Nguyen Thi Hoang Mai, Nguyen Hoan Phu, Guy E. Thwaites, Jesmond Dalli
Pubblicato in: The FASEB Journal, Numero 33/11, 2019, Pagina/e 13028-13039, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201901590R

Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19

Autori: Duco Steven Koenis, Issa Beegun, Charlotte Camille Jouvene, Gabriel Amador Aguirre, Patricia Regina Souza, Maria Gonzalez-Nunez, Lucy Ly, Kimberly Pistorius, Hemant M. Kocher, William Ricketts, Gavin Thomas, Mauro Perretti, Ghassan Alusi, Paul Pfeffer, Jesmond Dalli
Pubblicato in: Circulation Research, Numero 129/4, 2021, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.319142

Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology

Autori: Jesmond Dalli, Charles N Serhan
Pubblicato in: British Journal of Pharmacology, 2018, ISSN 0007-1188
Editore: Wiley-Blackwell
DOI: 10.1111/bph.14336

PDn-3 DPA Pathway Regulates Human Monocyte Differentiation and Macrophage Function

Autori: Kimberly Pistorius, Patricia R. Souza, Roberta De Matteis, Shani Austin-Williams, Karoline G. Primdahl, Anders Vik, Francesca Mazzacuva, Romain A. Colas, Raquel M. Marques, Trond V. Hansen, Jesmond Dalli
Pubblicato in: Cell Chemical Biology, Numero 25/6, 2018, Pagina/e 749-760.e9, ISSN 2451-9456
Editore: Elsevier Ltd.
DOI: 10.1016/j.chembiol.2018.04.017

A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults

Autori: Nguyen TH Mai, Nicholas Dobbs, Nguyen Hoan Phu, Romain A Colas, Le TP Thao, Nguyen TT Thuong, Ho DT Nghia, Nguyen HH Hanh, Nguyen T Hang, A Dorothee Heemskerk, Jeremy N Day, Lucy Ly, Do DA Thu, Laura Merson, Evelyne Kestelyn, Marcel Wolbers, Ronald Geskus, David Summers, Nguyen VV Chau, Jesmond Dalli, Guy E Thwaites
Pubblicato in: eLife, Numero 7, 2018, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.33478

Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy

Autori: Stephanie G. Dakin, Lucy Ly, Romain A. Colas, Udo Oppermann, Kim Wheway, Bridget Watkins, Jesmond Dalli, Andrew J. Carr
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-11188-y

13-Series resolvins mediate the leukocyte-platelet actions of atorvastatin and pravastatin in inflammatory arthritis

Autori: Mary E. Walker, Patricia R. Souza, Romain A. Colas, Jesmond Dalli
Pubblicato in: The FASEB Journal, Numero 31/8, 2017, Pagina/e 3636-3648, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201700268

Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution

Autori: Jesmond Dalli, Romain A. Colas, Hildur Arnardottir, Charles N. Serhan
Pubblicato in: Immunity, Numero 46/1, 2017, Pagina/e 92-105, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2016.12.009

Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans

Autori: Krishnaraj S. Rathod, Vikas Kapil, Shanti Velmurugan, Rayomand S. Khambata, Umme Siddique, Saima Khan, Sven Van Eijl, Lorna C. Gee, Jascharanpreet Bansal, Kavi Pitrola, Christopher Shaw, Fulvio D’Acquisto, Romain A. Colas, Federica Marelli-Berg, Jesmond Dalli, Amrita Ahluwalia
Pubblicato in: Journal of Clinical Investigation, Numero 127/1, 2017, Pagina/e 169-182, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/JCI89429

Protectin D1 n-3 DPA and resolvin D5 n-3 DPA are effectors of intestinal protection

Autori: Thomas Gobbetti, Jesmond Dalli, Romain A. Colas, Donata Federici Canova, Marius Aursnes, Delphine Bonnet, Laurent Alric, Nathalie Vergnolle, Celine Deraison, Trond V. Hansen, Charles N. Serhan, Mauro Perretti
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 114/15, 2017, Pagina/e 3963-3968, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1617290114

Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acid

Autori: Anders Vik, Jesmond Dalli, Trond Vidar Hansen
Pubblicato in: Bioorganic & Medicinal Chemistry Letters, Numero 27/11, 2017, Pagina/e 2259-2266, ISSN 0960-894X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2017.03.079

Resolving inflammation by using nutrition therapy

Autori: Lucy V. Norling, Lucy Ly, Jesmond Dalli
Pubblicato in: Current Opinion in Clinical Nutrition and Metabolic Care, 2016, Pagina/e 1, ISSN 1363-1950
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MCO.0000000000000353

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

Autori: Jesmond Dalli, Iliyan Vlasakov, Ian R. Riley, Ana R. Rodriguez, Bernd W. Spur, Nicos A. Petasis, Nan Chiang, Charles N. Serhan
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 113/43, 2016, Pagina/e 12232-12237, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1607003113

The novel lipid mediator PD1 n-3 DPA : An overview of the structural elucidation, synthesis, biosynthesis and bioactions

Autori: Trond Vidar Hansen, Jesmond Dalli, Charles N. Serhan
Pubblicato in: Prostaglandins & Other Lipid Mediators, 2017, ISSN 1098-8823
Editore: Elsevier BV
DOI: 10.1016/j.prostaglandins.2017.06.003

Immune resolution mechanisms in inflammatory arthritis

Autori: Mauro Perretti, Dianne Cooper, Jesmond Dalli, Lucy V. Norling
Pubblicato in: Nature Reviews Rheumatology, Numero 13/2, 2017, Pagina/e 87-99, ISSN 1759-4790
Editore: Nature Publishing Group
DOI: 10.1038/nrrheum.2016.193

Does promoting resolution instead of inhibiting inflammation represent the new paradigm in treating infections?

Autori: Jesmond Dalli
Pubblicato in: Molecular Aspects of Medicine, 2017, ISSN 0098-2997
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2017.03.007

Treatment With a Marine Oil Supplement Alters Lipid Mediators and Leukocyte Phenotype in Healthy Patients and Those With Peripheral Artery Disease

Autori: Melinda S. Schaller, Mian Chen, Romain A. Colas, Thomas A. Sorrentino, Ann A. Lazar, S. Marlene Grenon, Jesmond Dalli, Michael S. Conte
Pubblicato in: Journal of the American Heart Association, Numero 9/15, 2020, ISSN 2047-9980
Editore: Wiley-Blackwell
DOI: 10.1161/jaha.120.016113

Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis

Autori: Esteban A. Gomez, Romain A. Colas, Patricia R. Souza, Rebecca Hands, Myles J. Lewis, Conrad Bessant, Costantino Pitzalis, Jesmond Dalli
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-19176-z

Imbalance of proresolving lipid mediators in persistent allodynia dissociated from signs of clinical arthritis

Autori: Benjamin L. Allen, Karli Montague-Cardoso, Raffaele Simeoli, Romain A. Colas, Silvia Oggero, Bruno Vilar, Peter A. McNaughton, Jesmond Dalli, Mauro Perretti, Emanuele Sher, Marzia Malcangio
Pubblicato in: Pain, Numero 161/9, 2020, Pagina/e 2155-2166, ISSN 0304-3959
Editore: Elsevier BV
DOI: 10.1097/j.pain.0000000000001908

Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses

Autori: Patricia R. Souza, Raquel M. Marques, Esteban A. Gomez, Romain A. Colas, Roberta De Matteis, Anne Zak, Mital Patel, David J. Collier, Jesmond Dalli
Pubblicato in: Circulation Research, Numero 126/1, 2020, Pagina/e 75-90, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.315506

Proresolving Mediators LXB4 and RvE1 Regulate Inflammation in Stromal Cells from Patients with Shoulder Tendon Tears.

Autori: Stephanie G Dakin; Romain A Colas; Kim Wheway; Bridget Watkins; Louise Appleton; Jonathan Rees; Stephen Gwilym; Christopher Little; Jesmond Dalli; Andrew J Carr
Pubblicato in: American Journal of Pathology, Numero 2, 2019, ISSN 0002-9440
Editore: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2019.07.011