Resolution Pharmacology and Physiology of MCTR in Arthritis

Informacje na temat projektu

MCTRinIA

Identyfikator umowy o grant: 677542

DOI

10.3030/677542

Projekt został zamknięty

Data podpisania przez KE 4 Marca 2016

Data rozpoczęcia 1 Marca 2016

Data zakończenia 31 Sierpnia 2021

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 1 964 303,00

Wkład UE

€ 1 964 303,00

Koordynowany przez

QUEEN MARY UNIVERSITY OF LONDON
United Kingdom

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (31)

GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections

Autorzy: Magdalena B. Flak, Duco S. Koenis, Agua Sobrino, James Smith, Kimberly Pistorius, Francesco Palmas, Jesmond Dalli
Opublikowane w: Journal of Clinical Investigation, Numer 130/1, 2020, Strona(/y) 359-373, ISSN 0021-9738
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/jci131609

Protective activities of distinct omega-3 enriched oils are linked to their ability to upregulate specialized pro-resolving mediators

Autorzy: Agua Sobrino, Mary E. Walker, Romain A. Colas, Jesmond Dalli
Opublikowane w: PLOS ONE, Numer 15/12, 2020, Strona(/y) e0242543, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0242543

15‐Epi‐Lxa 4 and MaR1 counter inflammation in stromal cells from patients with Achilles tendinopathy and rupture

Autorzy: Stephanie G. Dakin, Romain A. Colas, Julia Newton, Stephen Gwilym, Natasha Jones, Hamish A. B. Reid, Simon Wood, Louise Appleton, Kim Wheway, Bridget Watkins, Jesmond Dalli, Andrew J. Carr
Opublikowane w: The FASEB Journal, Numer 33/7, 2019, Strona(/y) 8043-8054, ISSN 0892-6638
Wydawca: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201900196R

Dysregulated Maresin Concentrations in Plasma and Nasal Secretions From Patients With Chronic Rhinosinusitis

Autorzy: Issa Beegun, Duco S. Koenis, Ghassan Alusi, Jesmond Dalli
Opublikowane w: Frontiers in Immunology, Numer 12, 2021, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2021.733019

Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis.

Autorzy: Flak, Magdalena B.; Colas, Romain A.; Muñoz-Atienza, Estefanía; Curtis, Michael A.; Dalli, Jesmond; Pitzalis, Costantino
Opublikowane w: The Journal of Clinical Investigations Insights, Numer 3, 2019, ISSN 2379-3708
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.125191

Synthesis, Structural Confirmation, and Biosynthesis of 22-OH-PD1n-3 DPA

Autorzy: Jannicke Irina Nesman, Karoline Gangestad Primdahl, Jørn Eivind Tungen, Fransesco Palmas, Jesmond Dalli, Trond Vidar Hansen
Opublikowane w: Molecules, Numer 24/18, 2019, Strona(/y) 3228, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24183228

Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs

Autorzy: David M. Sokal, Alex McSloy, Matteo Donegà, Joseph Kirk, Romain A. Colas, Nikola Dolezalova, Esteban A. Gomez, Isha Gupta, Cathrine T. Fjordbakk, Sebastien Ouchouche, Paul B. Matteucci, Kristina Schlegel, Rizwan Bashirullah, Dirk Werling, Kim Harman, Alison Rowles, Refet Firat Yazicioglu, Jesmond Dalli, Daniel J. Chew, Justin D. Perkins
Opublikowane w: Frontiers in Immunology, Numer 12, 2021, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2021.649786

Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction

Autorzy: Linn E. Fosshaug, Romain A. Colas, Anne K. Anstensrud, Ida Gregersen, Ståle Nymo, Ellen L. Sagen, Annika Michelsen, Leif E. Vinge, Erik Øie, Lars Gullestad, Bente Halvorsen, Trond V. Hansen, Pål Aukrust, Jesmond Dalli, Arne Yndestad
Opublikowane w: EBioMedicine, Numer 46, 2019, Strona(/y) 264-273, ISSN 2352-3964
Wydawca: Elsevier BV
DOI: 10.1016/j.ebiom.2019.07.024

Dysregulated plasma lipid mediator profiles in critically ill COVID-19 patients

Autorzy: Francesco Palmas, Jennifer Clarke, Romain A. Colas, Esteban A. Gomez, Aoife Keogh, Maria Boylan, Natalie McEvoy, Oliver J. McElvaney, Oisin McElvaney, Razi Alalqam, Noel G. McElvaney, Gerard F. Curley, Jesmond Dalli
Opublikowane w: PLOS ONE, Numer 16/8, 2021, Strona(/y) e0256226, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0256226

n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis

Autorzy: Federica Frigerio, Giulia Pasqualini, Ilaria Craparotta, Sergio Marchini, Erwin A van Vliet, Patrick Foerch, Catherine Vandenplas, Karin Leclercq, Eleonora Aronica, Luca Porcu, Kimberly Pistorius, Romain A Colas, Trond V Hansen, Mauro Perretti, Rafal M Kaminski, Jesmond Dalli, Annamaria Vezzani
Opublikowane w: Brain, 2018, ISSN 0006-8950
Wydawca: Oxford University Press
DOI: 10.1093/brain/awy247

Proresolving mediator profiles in cerebrospinal fluid are linked with disease severity and outcome in adults with tuberculous meningitis

Autorzy: Romain A. Colas, Le Thanh Hoang Nhat, Nguyen Thuy Thuong Thuong, Esteban A. Gómez, Lucy Ly, Hai Hoang Thanh, Nguyen Thi Hoang Mai, Nguyen Hoan Phu, Guy E. Thwaites, Jesmond Dalli
Opublikowane w: The FASEB Journal, Numer 33/11, 2019, Strona(/y) 13028-13039, ISSN 0892-6638
Wydawca: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201901590R

Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19

Autorzy: Duco Steven Koenis, Issa Beegun, Charlotte Camille Jouvene, Gabriel Amador Aguirre, Patricia Regina Souza, Maria Gonzalez-Nunez, Lucy Ly, Kimberly Pistorius, Hemant M. Kocher, William Ricketts, Gavin Thomas, Mauro Perretti, Ghassan Alusi, Paul Pfeffer, Jesmond Dalli
Opublikowane w: Circulation Research, Numer 129/4, 2021, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.319142

Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology

Autorzy: Jesmond Dalli, Charles N Serhan
Opublikowane w: British Journal of Pharmacology, 2018, ISSN 0007-1188
Wydawca: Wiley-Blackwell
DOI: 10.1111/bph.14336

PDn-3 DPA Pathway Regulates Human Monocyte Differentiation and Macrophage Function

Autorzy: Kimberly Pistorius, Patricia R. Souza, Roberta De Matteis, Shani Austin-Williams, Karoline G. Primdahl, Anders Vik, Francesca Mazzacuva, Romain A. Colas, Raquel M. Marques, Trond V. Hansen, Jesmond Dalli
Opublikowane w: Cell Chemical Biology, Numer 25/6, 2018, Strona(/y) 749-760.e9, ISSN 2451-9456
Wydawca: Elsevier Ltd.
DOI: 10.1016/j.chembiol.2018.04.017

A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults

Autorzy: Nguyen TH Mai, Nicholas Dobbs, Nguyen Hoan Phu, Romain A Colas, Le TP Thao, Nguyen TT Thuong, Ho DT Nghia, Nguyen HH Hanh, Nguyen T Hang, A Dorothee Heemskerk, Jeremy N Day, Lucy Ly, Do DA Thu, Laura Merson, Evelyne Kestelyn, Marcel Wolbers, Ronald Geskus, David Summers, Nguyen VV Chau, Jesmond Dalli, Guy E Thwaites
Opublikowane w: eLife, Numer 7, 2018, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/eLife.33478

Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy

Autorzy: Stephanie G. Dakin, Lucy Ly, Romain A. Colas, Udo Oppermann, Kim Wheway, Bridget Watkins, Jesmond Dalli, Andrew J. Carr
Opublikowane w: Scientific Reports, Numer 7/1, 2017, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-017-11188-y

13-Series resolvins mediate the leukocyte-platelet actions of atorvastatin and pravastatin in inflammatory arthritis

Autorzy: Mary E. Walker, Patricia R. Souza, Romain A. Colas, Jesmond Dalli
Opublikowane w: The FASEB Journal, Numer 31/8, 2017, Strona(/y) 3636-3648, ISSN 0892-6638
Wydawca: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201700268

Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution

Autorzy: Jesmond Dalli, Romain A. Colas, Hildur Arnardottir, Charles N. Serhan
Opublikowane w: Immunity, Numer 46/1, 2017, Strona(/y) 92-105, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2016.12.009

Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans

Autorzy: Krishnaraj S. Rathod, Vikas Kapil, Shanti Velmurugan, Rayomand S. Khambata, Umme Siddique, Saima Khan, Sven Van Eijl, Lorna C. Gee, Jascharanpreet Bansal, Kavi Pitrola, Christopher Shaw, Fulvio D’Acquisto, Romain A. Colas, Federica Marelli-Berg, Jesmond Dalli, Amrita Ahluwalia
Opublikowane w: Journal of Clinical Investigation, Numer 127/1, 2017, Strona(/y) 169-182, ISSN 0021-9738
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/JCI89429

Protectin D1 n-3 DPA and resolvin D5 n-3 DPA are effectors of intestinal protection

Autorzy: Thomas Gobbetti, Jesmond Dalli, Romain A. Colas, Donata Federici Canova, Marius Aursnes, Delphine Bonnet, Laurent Alric, Nathalie Vergnolle, Celine Deraison, Trond V. Hansen, Charles N. Serhan, Mauro Perretti
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 114/15, 2017, Strona(/y) 3963-3968, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1617290114

Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acid

Autorzy: Anders Vik, Jesmond Dalli, Trond Vidar Hansen
Opublikowane w: Bioorganic & Medicinal Chemistry Letters, Numer 27/11, 2017, Strona(/y) 2259-2266, ISSN 0960-894X
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2017.03.079

Resolving inflammation by using nutrition therapy

Autorzy: Lucy V. Norling, Lucy Ly, Jesmond Dalli
Opublikowane w: Current Opinion in Clinical Nutrition and Metabolic Care, 2016, Strona(/y) 1, ISSN 1363-1950
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MCO.0000000000000353

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

Autorzy: Jesmond Dalli, Iliyan Vlasakov, Ian R. Riley, Ana R. Rodriguez, Bernd W. Spur, Nicos A. Petasis, Nan Chiang, Charles N. Serhan
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 113/43, 2016, Strona(/y) 12232-12237, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1607003113

The novel lipid mediator PD1 n-3 DPA : An overview of the structural elucidation, synthesis, biosynthesis and bioactions

Autorzy: Trond Vidar Hansen, Jesmond Dalli, Charles N. Serhan
Opublikowane w: Prostaglandins & Other Lipid Mediators, 2017, ISSN 1098-8823
Wydawca: Elsevier BV
DOI: 10.1016/j.prostaglandins.2017.06.003

Immune resolution mechanisms in inflammatory arthritis

Autorzy: Mauro Perretti, Dianne Cooper, Jesmond Dalli, Lucy V. Norling
Opublikowane w: Nature Reviews Rheumatology, Numer 13/2, 2017, Strona(/y) 87-99, ISSN 1759-4790
Wydawca: Nature Publishing Group
DOI: 10.1038/nrrheum.2016.193

Does promoting resolution instead of inhibiting inflammation represent the new paradigm in treating infections?

Autorzy: Jesmond Dalli
Opublikowane w: Molecular Aspects of Medicine, 2017, ISSN 0098-2997
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2017.03.007

Treatment With a Marine Oil Supplement Alters Lipid Mediators and Leukocyte Phenotype in Healthy Patients and Those With Peripheral Artery Disease

Autorzy: Melinda S. Schaller, Mian Chen, Romain A. Colas, Thomas A. Sorrentino, Ann A. Lazar, S. Marlene Grenon, Jesmond Dalli, Michael S. Conte
Opublikowane w: Journal of the American Heart Association, Numer 9/15, 2020, ISSN 2047-9980
Wydawca: Wiley-Blackwell
DOI: 10.1161/jaha.120.016113

Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis

Autorzy: Esteban A. Gomez, Romain A. Colas, Patricia R. Souza, Rebecca Hands, Myles J. Lewis, Conrad Bessant, Costantino Pitzalis, Jesmond Dalli
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-19176-z

Imbalance of proresolving lipid mediators in persistent allodynia dissociated from signs of clinical arthritis

Autorzy: Benjamin L. Allen, Karli Montague-Cardoso, Raffaele Simeoli, Romain A. Colas, Silvia Oggero, Bruno Vilar, Peter A. McNaughton, Jesmond Dalli, Mauro Perretti, Emanuele Sher, Marzia Malcangio
Opublikowane w: Pain, Numer 161/9, 2020, Strona(/y) 2155-2166, ISSN 0304-3959
Wydawca: Elsevier BV
DOI: 10.1097/j.pain.0000000000001908

Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses

Autorzy: Patricia R. Souza, Raquel M. Marques, Esteban A. Gomez, Romain A. Colas, Roberta De Matteis, Anne Zak, Mital Patel, David J. Collier, Jesmond Dalli
Opublikowane w: Circulation Research, Numer 126/1, 2020, Strona(/y) 75-90, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.315506

Proresolving Mediators LXB4 and RvE1 Regulate Inflammation in Stromal Cells from Patients with Shoulder Tendon Tears.

Autorzy: Stephanie G Dakin; Romain A Colas; Kim Wheway; Bridget Watkins; Louise Appleton; Jonathan Rees; Stephen Gwilym; Christopher Little; Jesmond Dalli; Andrew J Carr
Opublikowane w: American Journal of Pathology, Numer 2, 2019, ISSN 0002-9440
Wydawca: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2019.07.011