Artificial endosymbiosis

Informazioni relative al progetto

ARTISYM

ID dell’accordo di sovvenzione: 694120

DOI

10.3030/694120

Progetto chiuso

Data della firma CE 24 Ottobre 2016

Data di avvio 1 Gennaio 2017

Data di completamento 31 Dicembre 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 500 000,00

Contributo UE

€ 2 500 000,00

Coordinato da

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (36)

Dual Site-Selective Presentation of Functional Handles on Protein-Engineered Cowpea Chlorotic Mottle Virus-Like Particles

Autori: Daan F. M. Vervoort, Robin Heiringhoff, Suzanne B. P. E. Timmermans, Marleen H. M. E. van Stevendaal, Jan C. M. van Hest
Pubblicato in: Bioconjugate Chemistry, Numero 32/5, 2021, Pagina/e 958-963, ISSN 1043-1802
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.1c00108

Therapeutic Stomatocytes with Aggregation Induced Emission for Intracellular Delivery

Autori: Jingxin Shao, Shoupeng Cao, Hanglong Wu, Loai KEA Abdelmohsen, Jan C.M. van Hest
Pubblicato in: PHARMACEUTICS, 2021, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13111833

Amphiphilic AIEgen-polymer aggregates: Design, self-assembly and biomedical applications

Autori: Shoupeng Cao,Jingxin Shao,Loai K. E. A. Abdelmohsen,Jan C. M. van Hest
Pubblicato in: Aggregate, 2021, ISSN 2692-4560
Editore: John Wiley and Sons
DOI: 10.1002/agt2.128

Photoactivated Polymersome Nanomotors: Traversing Biological Barriers

Autori: Jingxin Shao, Shoupeng Cao, David S. Williams, Loai K. E. A. Abdelmohsen, Jan C. M. Hest
Pubblicato in: Angewandte Chemie International Edition, Numero 59/39, 2020, Pagina/e 16918-16925, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202003748

Biodegradable Polymersomes with Structure Inherent Fluorescence and Targeting Capacity for Enhanced Photo-Dynamic Therapy

Autori: Shoupeng Cao,Yifeng Xia,Jingxin Shao,Beibei Guo,Yangyang Dong, Imke A. B. Pijpers, Zhiyuan Zhong,Fenghua Meng, Loai K. E. A. Abdelmohsen,David S. Williams, Jan C. M. van Hest
Pubblicato in: Angewandte Chemie Int Ed, 2021, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202105103

Pathway dependent shape-transformation of azide-decorated polymersomes

Autori: Hailong Che, Lafayette N. J. de Windt, Jianzhi Zhu, Imke A. B. Pijpers, Alexander F. Mason, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest
Pubblicato in: Chemical Communications, Numero 56/14, 2020, Pagina/e 2127-2130, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c9cc08944f

Programmed spatial organization of biomacromolecules into discrete, coacervate-based protocells

Autori: Wiggert J. Altenburg, N. Amy Yewdall, Daan F. M. Vervoort, Marleen H. M. E. van Stevendaal, Alexander F. Mason, Jan C. M. van Hest
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-20124-0

Cucurbit-Like Polymersomes with Aggregation-Induced Emission Properties Show Enzyme-Mediated Motility

Autori: Shoupeng Cao, Hanglong Wu, Imke A. B. Pijpers, Jingxin Shao, Loai K. E. A. Abdelmohsen, David S. Williams, Jan C. M. van Hest
Pubblicato in: ACS Nano, 2021, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.1c07343

Engineering transient dynamics of artificial cells by stochastic distribution of enzymes

Autori: Shidong Song, Alexander F. Mason, Richard AJ Post, Marco De Corato, Rafael Mestre, N Amy Yewdall, Shoupeng Cao, Remco W van der Hofstad, Samuel Sanchez, Loai KEA Abdelmohsen, Jan C.M. van Hest
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-27229-0

Artificial Organelles: Towards Adding or Restoring Intracellular Activity

Autori: Roy A. J. F. Oerlemans, Suzanne B. P. E. Timmermans, Jan C. M. Hest
Pubblicato in: ChemBioChem, Numero 22/12, 2021, Pagina/e 2051-2078, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000850

Engineering of Biocompatible Coacervate-Based Synthetic Cells

Autori: Marleen H. M. E. van Stevendaal, Laurynas Vasiukas, N. Amy Yewdall, Alexander F. Mason, Jan C. M. van Hest
Pubblicato in: ACS Applied Materials & Interfaces, Numero 13/7, 2021, Pagina/e 7879-7889, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.0c19052

Biomimicry of Cellular Motility and Communication Based on Synthetic Soft-Architectures

Autori: Lei Wang, Shidong Song,Jan C.M. van Hest, Loai KEA Abdelmohsen, Xin Huang, Samuel Sanchez
Pubblicato in: Small, 2021, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201907680

Intercellular communication between artificial cells by allosteric amplification of a molecular signal

Autori: Bastiaan C. Buddingh’, Janneke Elzinga, Jan C. M. van Hest
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-15482-8

Terpolymer-stabilized complex coacervates: A robust and versatile synthetic cell platform

Autori: Alexander F. Mason,Wiggert J. Altenburg, Shidong Song, Marleen van Stevendaal, Jan C.M. van Hest
Pubblicato in: Methods in enzymology, 2021, ISSN 0076-6879
Editore: Academic Press
DOI: 10.1016/bs.mie.2020.06.008

Morphology Under Control: Engineering Biodegradable Stomatocytes

Autori: Imke A. B. Pijpers, Loai K. E. A. Abdelmohsen, David S. Williams, Jan C. M. van Hest
Pubblicato in: ACS Macro Letters, Numero 6/11, 2017, Pagina/e 1217-1222, ISSN 2161-1653
Editore: American Chemical Society
DOI: 10.1021/acsmacrolett.7b00723

Feedback-Induced Temporal Control of “Breathing” Polymersomes To Create Self-Adaptive Nanoreactors

Autori: Hailong Che, Shoupeng Cao, Jan C. M. van Hest
Pubblicato in: Journal of the American Chemical Society, Numero 140/16, 2018, Pagina/e 5356-5359, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.8b02387

Hierarchical Self-Assembly of a Copolymer-Stabilized Coacervate Protocell

Autori: Alexander F. Mason, Bastiaan C. Buddingh’, David S. Williams, Jan C. M. van Hest
Pubblicato in: Journal of the American Chemical Society, Numero 139/48, 2017, Pagina/e 17309-17312, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.7b10846

Biodegradable Synthetic Organelles Demonstrate ROS Shielding in Human-Complex-I-Deficient Fibroblasts

Autori: Lisanne M. P. E. van Oppen, Loai K. E. A. Abdelmohsen, Sjenet E. van Emst-de Vries, Pascal L. W. Welzen, Daniela A. Wilson, Jan A. M. Smeitink, Werner J. H. Koopman, Roland Brock, Peter H. G. M. Willems, David S. Williams, Jan C.M. van Hest
Pubblicato in: ACS Central Science, Numero 4/7, 2018, Pagina/e 917-928, ISSN 2374-7943
Editore: American Chemical Society
DOI: 10.1021/acscentsci.8b00336

Self-Assembly and Stabilization of Hybrid Cowpea Chlorotic Mottle Virus Particles under Nearly Physiological Conditions

Autori: Suzanne B. P. E. Timmermans, Daan F. M. Vervoort, Lise Schoonen, Roeland J. M. Nolte, Jan C. M. van Hest
Pubblicato in: Chemistry - An Asian Journal, Numero 13/22, 2018, Pagina/e 3518-3525, ISSN 1861-4728
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/asia.201800842

Erythrocyte Membrane Modified Janus Polymeric Motors for Thrombus Therapy

Autori: Jingxin Shao, Mona Abdelghani, Guizhi Shen, Shoupeng Cao, David S. Williams, Jan C. M. van Hest
Pubblicato in: ACS Nano, Numero 12/5, 2018, Pagina/e 4877-4885, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.8b01772

Physicochemical Characterization of Polymer‐stabilized Coacervate Protocells

Autori: N. Amy Yewdall, Bastiaan C. Buddingh’, Wiggert J. Altenburg, Suzanne B. P. E. Timmermans, Daan F. M. Vervoort, Loai K.E.A. Abdelmohsen, Alexander F. Mason, Jan van Hest
Pubblicato in: ChemBioChem, 2019, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900195

The hallmarks of living systems: towards creating artificial cells

Autori: N. Amy Yewdall, Alexander F. Mason, Jan C. M. van Hest
Pubblicato in: Interface Focus, Numero 8/5, 2018, Pagina/e 20180023, ISSN 2042-8898
Editore: Royal Society Publishing
DOI: 10.1098/rsfs.2018.0023

Development of Morphologically Discrete PEG–PDLLA Nanotubes for Precision Nanomedicine

Autori: Annelies C. Wauters, Imke A. B. Pijpers, Alexander F. Mason, David S. Williams, Jurjen Tel, Loai K. E. A. Abdelmohsen, Jan C.M. van Hest
Pubblicato in: Biomacromolecules, Numero 20/1, 2018, Pagina/e 177-183, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.8b01245

Biomorphic Engineering of Multifunctional Polylactide Stomatocytes toward Therapeutic Nano-Red Blood Cells

Autori: Jingxin Shao, Imke A. B. Pijpers, Shoupeng Cao, David S. Williams, Xuehai Yan, Junbai Li, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest
Pubblicato in: Advanced Science, Numero 6/5, 2019, Pagina/e 1801678, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.201801678

pH-Induced Transformation of Biodegradable Multilamellar Nanovectors for Enhanced Tumor Penetration

Autori: Shoupeng Cao, Loai K. E. A. Abdelmohsen, Jingxin Shao, Joep van den Dikkenberg, Enrico Mastrobattista, David S. Williams, Jan C. M. van Hest
Pubblicato in: ACS Macro Letters, Numero 7/11, 2018, Pagina/e 1394-1399, ISSN 2161-1653
Editore: American Chemical Society
DOI: 10.1021/acsmacrolett.8b00807

Mimicking Cellular Compartmentalization in a Hierarchical Protocell through Spontaneous Spatial Organization

Autori: Alexander F. Mason, N. Amy Yewdall, Pascal L. W. Welzen, Jingxin Shao, Marleen van Stevendaal, Jan C. M. van Hest, David S. Williams, Loai K. E. A. Abdelmohsen
Pubblicato in: ACS Central Science, Numero 5/8, 2019, Pagina/e 1360-1365, ISSN 2374-7943
Editore: ACS
DOI: 10.1021/acscentsci.9b00345

Adaptive Polymeric Assemblies for Applications in Biomimicry and Nanomedicine

Autori: Yigit Altay, Shoupeng Cao, Hailong Che, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest
Pubblicato in: Biomacromolecules, Numero 20/11, 2019, Pagina/e 4053-4064, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.9b01341

Adaptive Polymersome Nanoreactors

Autori: Hailong Che, Jan C. M. van Hest
Pubblicato in: ChemNanoMat, Numero 5/9, 2019, Pagina/e 1092-1109, ISSN 2199-692X
Editore: Wiley
DOI: 10.1002/cnma.201900245

Self-Regulated and Temporal Control of a “Breathing” Microgel Mediated by Enzymatic Reaction

Autori: Hailong Che, Bastiaan C. Buddingh', Jan C. M. van Hest
Pubblicato in: Angewandte Chemie International Edition, Numero 56/41, 2017, Pagina/e 12581-12585, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201706716

Molecular Programming of Biodegradable Nanoworms via Ionically Induced Morphology Switch toward Asymmetric Therapeutic Carriers

Autori: Shoupeng Cao, Jingxin Shao, Yifeng Xia, Hailong Che, Zhiyuan Zhong, Fenghua Meng, Jan C. M. van Hest, Loai K. E. A. Abdelmohsen, David S. Williams
Pubblicato in: Small, Numero 15/38, 2019, Pagina/e 1901849, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201901849

Photoactivated nanomotors via aggregation induced emission for enhanced phototherapy

Autori: Shoupeng Cao, Jingxin Shao, Hanglong Wu, Shidong Song, Maria Teresa De Martino, Imke A. B. Pijpers, Heiner Friedrich, Loai K. E. A. Abdelmohsen, David S. Williams, Jan C. M. van Hest
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-22279-w

ATP‐Mediated Transient Behavior of Stomatocyte Nanosystems

Autori: Hailong Che, Jianzhi Zhu, Shidong Song, Alexander F. Mason, Shoupeng Cao, Imke A. B. Pijpers, Loai K. E. A. Abdelmohsen, Jan C. M. Hest
Pubblicato in: Angewandte Chemie, Numero 131/37, 2019, Pagina/e 13247-13252, ISSN 0044-8249
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.201906331

Compartmentalized cross-linked enzymatic nano -aggregates ( c -CLE n A) for efficient in-flow biocatalysis

Autori: M. Teresa De Martino, Fabio Tonin, N. Amy Yewdall, Mona Abdelghani, David S. Williams, Ulf Hanefeld, Floris P. J. T. Rutjes, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest
Pubblicato in: Chemical Science, Numero 11/10, 2020, Pagina/e 2765-2769, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c9sc05420k

Dynamic spatial and structural organization in artificial cells regulates signal processing by protein scaffolding

Autori: Bastiaan C. Buddingh', Antoni Llopis-Lorente, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest
Pubblicato in: Chemical Science, Numero 11/47, 2020, Pagina/e 12829-12834, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sc03933k

Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis

Autori: Imke A. B. Pijpers, Shoupeng Cao, Antoni Llopis-Lorente, Jianzhi Zhu, Shidong Song, Rick R. M. Joosten, Fenghua Meng, Heiner Friedrich, David S. Williams, Samuel Sánchez, Jan C. M. van Hest, Loai K. E. A. Abdelmohsen
Pubblicato in: Nano Letters, Numero 20/6, 2020, Pagina/e 4472-4480, ISSN 1530-6984
Editore: American Chemical Society
DOI: 10.1021/acs.nanolett.0c01268

Supramolecular Nanoscaffolds within Cytomimetic Protocells as Signal Localization Hubs

Autori: Eva Magdalena Estirado, Alexander F. Mason, Miguel Ángel Alemán García, Jan C. M. van Hest, Luc Brunsveld
Pubblicato in: Journal of the American Chemical Society, Numero 142/20, 2020, Pagina/e 9106-9111, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.0c01732