Elucidating natural bilayer lipid environments

Información del proyecto

ENABLE

Identificador del acuerdo de subvención: 695511

DOI

10.3030/695511

Proyecto cerrado

Fecha de la firma de la CE 17 Mayo 2016

Fecha de inicio 1 Junio 2016

Fecha de finalización 31 Mayo 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 481 744,00

Aportación de la UE

€ 2 481 744,00

Coordinado por

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (22)

N-glycan microheterogeneity regulates interactions of plasma proteins

Autores: Di Wu, Weston B. Struwe, David J. Harvey, Michael A. J. Ferguson, Carol V. Robinson
Publicado en: Proceedings of the National Academy of Sciences, Edición 115/35, 2018, Página(s) 8763-8768, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1807439115

Allosteric Inhibition of the SARS‐CoV‐2 Main Protease: Insights from Mass Spectrometry Based Assays**

Autores: Tarick J. El‐Baba, Corinne A. Lutomski, Anastassia L. Kantsadi, Tika R. Malla, Tobias John, Victor Mikhailov, Jani R. Bolla, Christopher J. Schofield, Nicole Zitzmann, Ioannis Vakonakis, Carol V. Robinson
Publicado en: Angewandte Chemie International Edition, Edición 59/52, 2020, Página(s) 23544-23548, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202010316

Dynamics of an LPS translocon induced by substrate and an antimicrobial peptide

Autores: Francesco Fiorentino, Joshua B. Sauer, Xingyu Qiu, Robin A. Corey, C. Keith Cassidy, Benjamin Mynors-Wallis, Shahid Mehmood, Jani R. Bolla, Phillip J. Stansfeld, Carol V. Robinson
Publicado en: Nature Chemical Biology, Edición 17/2, 2021, Página(s) 187-195, ISSN 1552-4450
Editor: Nature Publishing Group
DOI: 10.1038/s41589-020-00694-2

Structure of native lens connexin 46/50 intercellular channels by cryo-EM

Autores: Janette B. Myers, Bassam G. Haddad, Susan E. O’Neill, Dror S. Chorev, Craig C. Yoshioka, Carol V. Robinson, Daniel M. Zuckerman, Steve L. Reichow
Publicado en: Nature, Edición 564/7736, 2018, Página(s) 372-377, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-018-0786-7

The use of sonicated lipid vesicles for mass spectrometry of membrane protein complexes

Autores: Dror S. Chorev, Haiping Tang, Sarah L. Rouse, Jani Reddy Bolla, Andriko von Kügelgen, Lindsay A. Baker, Di Wu, Joseph Gault, Kay Grünewald, Tanmay A. M. Bharat, Stephen J. Matthews, Carol V. Robinson
Publicado en: Nature Protocols, Edición 15/5, 2020, Página(s) 1690-1706, ISSN 1754-2189
Editor: Nature Publishing Group
DOI: 10.1038/s41596-020-0303-y

Combining native and ‘omics’ mass spectrometry to identify endogenous ligands bound to membrane proteins

Autores: Joseph Gault, Idlir Liko, Michael Landreh, Denis Shutin, Jani Reddy Bolla, Damien Jefferies, Mark Agasid, Hsin-Yung Yen, Marcus J. G. W. Ladds, David P. Lane, Syma Khalid, Christopher Mullen, Philip M. Remes, Romain Huguet, Graeme McAlister, Michael Goodwin, Rosa Viner, John E.P. Syka, Carol V. Robinson
Publicado en: Nature Methods, Edición 17/5, 2020, Página(s) 505-508, ISSN 1548-7091
Editor: Nature Publishing Group
DOI: 10.1038/s41592-020-0821-0

Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors

Autores: Leonhard H. Urner, Idlir Liko, Hsin-Yung Yen, Kin-Kuan Hoi, Jani Reddy Bolla, Joseph Gault, Fernando Gonçalves Almeida, Marc-Philip Schweder, Denis Shutin, Svenja Ehrmann, Rainer Haag, Carol V. Robinson, Kevin Pagel
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-14424-8

In Situ Structure of an Intact Lipopolysaccharide-Bound Bacterial Surface Layer

Autores: Andriko von Kügelgen, Haiping Tang, Gail G. Hardy, Danguole Kureisaite-Ciziene, Yves V. Brun, Phillip J. Stansfeld, Carol V. Robinson, Tanmay A.M. Bharat
Publicado en: Cell, Edición 180/2, 2020, Página(s) 348-358.e15, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2019.12.006

Phospho‐regulation, nucleotide binding and ion access control in potassium‐chloride cotransporters

Autores: Gamma Chi, Rebecca Ebenhoch, Henry Man, Haiping Tang, Laurence E Tremblay, Gabriella Reggiano, Xingyu Qiu, Tina Bohstedt, Idlir Liko, Fernando G Almeida, Alexandre P Garneau, Dong Wang, Gavin McKinley, Christophe P Moreau, Kiran D Bountra, Patrizia Abrusci, Shubhashish M M Mukhopadhyay, Alejandra Fernandez‐Cid, Samira Slimani, Julie L Lavoie, Nicola A Burgess‐Brown, Ben Tehan, Frank DiMaio, Al
Publicado en: The EMBO Journal, 2021, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2020107294

Dendritic Oligoglycerol Regioisomer Mixtures and Their Utility for Membrane Protein Research

Autores: Leonhard H. Urner, Katharina Goltsche, Marleen Selent, Idlir Liko, Marc‐Philip Schweder, Carol V. Robinson, Kevin Pagel, Rainer Haag
Publicado en: Chemistry – A European Journal, Edición 27/7, 2021, Página(s) 2537-2542, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202003991

A new azobenzene-based design strategy for detergents in membrane protein research

Autores: Leonhard H. Urner, Maiko Schulze, Yasmine B. Maier, Waldemar Hoffmann, Stephan Warnke, Idlir Liko, Kristin Folmert, Christian Manz, Carol V. Robinson, Rainer Haag, Kevin Pagel
Publicado en: Chemical Science, Edición 11/13, 2020, Página(s) 3538-3546, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d0sc01022g

The importance of the membrane for biophysical measurements

Autores: Dror S. Chorev, Carol V. Robinson
Publicado en: Nature Chemical Biology, Edición 16/12, 2020, Página(s) 1285-1292, ISSN 1552-4450
Editor: Nature Publishing Group
DOI: 10.1038/s41589-020-0574-1

Ligand binding to a G protein–coupled receptor captured in a mass spectrometer

Autores: Hsin-Yung Yen, Jonathan T. S. Hopper, Idlir Liko, Timothy M. Allison, Ya Zhu, Dejian Wang, Monika Stegmann, Shabaz Mohammed, Beili Wu, Carol V. Robinson
Publicado en: Science Advances, Edición 3/6, 2017, Página(s) e1701016, ISSN 2375-2548
Editor: AAAS
DOI: 10.1126/sciadv.1701016

Identifying key membrane protein lipid interactions using mass spectrometry

Autores: Kallol Gupta, Jingwen Li, Idlir Liko, Joseph Gault, Cherine Bechara, Di Wu, Jonathan T S Hopper, Kevin Giles, Justin L P Benesch, Carol V Robinson
Publicado en: Nature Protocols, Edición 13/5, 2018, Página(s) 1106-1120, ISSN 1754-2189
Editor: Nature Publishing Group
DOI: 10.1038/nprot.2018.014

Native Desorption Electrospray Ionization Liberates Soluble and Membrane Protein Complexes from Surfaces

Autores: Stephen Ambrose, Nicholas G. Housden, Kallol Gupta, Jieyuan Fan, Paul White, Hsin-Yung Yen, Julien Marcoux, Colin Kleanthous, Jonathan T. S. Hopper, Carol V. Robinson
Publicado en: Angewandte Chemie International Edition, Edición 56/46, 2017, Página(s) 14463-14468, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201704849

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

Autores: Hsin-Yung Yen, Kin Kuan Hoi, Idlir Liko, George Hedger, Michael R. Horrell, Wanling Song, Di Wu, Philipp Heine, Tony Warne, Yang Lee, Byron Carpenter, Andreas Plückthun, Christopher G. Tate, Mark S. P. Sansom, Carol V. Robinson
Publicado en: Nature, Edición 559/7714, 2018, Página(s) 423-427, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-018-0325-6

Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry

Autores: Dror S. Chorev, Lindsay A. Baker, Di Wu, Victoria Beilsten-Edmands, Sarah L. Rouse, Tzviya Zeev-Ben-Mordehai, Chimari Jiko, Firdaus Samsudin, Christoph Gerle, Syma Khalid, Alastair G. Stewart, Stephen J. Matthews, Kay Grünewald, Carol V. Robinson
Publicado en: Science, Edición 362/6416, 2018, Página(s) 829-834, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aau0976

The role of interfacial lipids in stabilizing membrane protein oligomers

Autores: Kallol Gupta, Joseph A. C. Donlan, Jonathan T. S. Hopper, Povilas Uzdavinys, Michael Landreh, Weston B. Struwe, David Drew, Andrew J. Baldwin, Phillip J. Stansfeld, Carol V. Robinson
Publicado en: Nature, Edición 541/7637, 2017, Página(s) 421-424, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature20820

Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters

Autores: Michael Landreh, Erik G. Marklund, Povilas Uzdavinys, Matteo T. Degiacomi, Mathieu Coincon, Joseph Gault, Kallol Gupta, Idlir Liko, Justin L. P. Benesch, David Drew, Carol V. Robinson
Publicado en: Nature Communications, Edición 8, 2017, Página(s) 13993, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms13993

From molecular chaperones to membrane motors: through the lens of a mass spectrometrist

Autores: Carol V. Robinson
Publicado en: Biochemical Society Transactions, Edición 45/1, 2017, Página(s) 251-260, ISSN 0300-5127
Editor: Portland Press, Ltd.
DOI: 10.1042/bst20160395

Structure of the Fanconi anaemia monoubiquitin ligase complex

Autores: Shabih Shakeel, Eeson Rajendra, Pablo Alcón, Francis O’Reilly, Dror S. Chorev, Sarah Maslen, Gianluca Degliesposti, Christopher J. Russo, Shaoda He, Chris H. Hill, J. Mark Skehel, Sjors H. W. Scheres, Ketan J. Patel, Juri Rappsilber, Carol V. Robinson, Lori A. Passmore
Publicado en: Nature, Edición 575/7781, 2019, Página(s) 234-237, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1703-4

Direct observation of the influence of cardiolipin and antibiotics on lipid II binding to MurJ

Autores: Jani Reddy Bolla, Joshua B. Sauer, Di Wu, Shahid Mehmood, Timothy M. Allison, Carol V. Robinson
Publicado en: Nature Chemistry, Edición 10/3, 2018, Página(s) 363-371, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/nchem.2919