'Tissue is the issue': a multi-omics approach to improve prostate cancer diagnosis

Project Information

ProstOmics

Grant agreement ID: 758306

DOI

10.3030/758306

Project closed

EC signature date 23 January 2018

Start date 1 February 2018

End date 30 September 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Conference proceedings (3)

A0948 - Multiomics spatial mapping of lipid metabolism in prostate cancer

Author(s): M.K. Andersen, S. Krossa, M. Elise, T. Viset, Ø. Størkersen, G.F. Giskeødegård, M.B. Rye, M-B. Tessem
Published in: European Urology, Issue 1, 2022
Publisher: Elsevier

A0942 - DNA methylation aberrations predicts recurrence both in tumor and normal appearing prostate tissue

Author(s): C. Pedersen, E. Midtbust, S. Krossa, M.K. Andersen, T. Viset, Ø. Størkersen, G.F. Giskeødegård, M.B. Rye, M-B. Tessem
Published in: European Urology, Issue 1, 2022
Publisher: Elsevier

A0950 - Inflammatory chemokines upregulated in the tumor microenvironment of prostate cancer patients experiencing relapse after radical prostatectomy

Author(s): S. Krossa, M.K. Andersen, E. Midtbust, T. Viset, Ø. Størkersen, G.F. Giskeødegård, M.B. Rye, M-B. Tessem,
Published in: European Urology, Issue 1, 2022
Publisher: Elsivier

Peer reviewed articles (19)

A0950 - Inflammatory chemokines upregulated in the tumor microenvironment of prostate cancer patients experiencing relapse after radical prostatectomy

Author(s): S. Krossa, M.K. Andersen, E. Midtbust, T. Viset, Ø. Størkersen, G.F. Giskeødegård, M.B. Rye, M-B. Tessem,
Published in: European Urology, 2022, ISSN 0302-2838
Publisher: Elsevier BV
DOI: 10.1016/s0302-2838(22)01025-9

Spatial transcriptomics reveals strong association between SFRP4 and extracellular matrix remodeling in prostate cancer

Author(s): Maria K. Andersen, Sebastian Krossa, Elise Midtbust, Christine A. Pedersen, Maximilian Wess, Therese S. Høiem, Trond Viset, Øystein Størkersen, Ingunn Nervik, Elise Sandsmark, Helena Bertilsson, Guro F. Giskeødegård, Morten B. Rye, May-Britt Tessem
Published in: Communications Biology, Issue 7, 2024, ISSN 2399-3642
Publisher: Nature portfolio
DOI: 10.1038/s42003-024-07161-x

DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival

Author(s): Christine Aaserød Pedersen; Maria Dung Cao; Thomas Fleischer; Morten B. Rye; Stian Knappskog; Hans Petter Eikesdal; Per Eystein Lønning; Jörg Tost; Vessela N. Kristensen; May-Britt Tessem; Guro F. Giskeødegård; Tone F. Bathen
Published in: Breast cancer Research, Issue 1, 2022, ISSN 1465-542X
Publisher: Springer NAture
DOI: 10.1186/s13058-022-01537-9

FunHoP: Enhanced Visualization and Analysis of Functionally Homologous Proteins in Complex Metabolic Networks

Author(s): Kjersti Rise, May-Britt Tessem, Finn Drabløs, Morten B. Rye
Published in: Genomics, Proteomics & Bioinformatics, Issue 19, 2024, Page(s) 848-859, ISSN 1672-0229
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.1016/j.gpb.2021.03.003

The genes controlling normal function of citrate and spermine secretion are lost in aggressive prostate cancer and prostate model systems

Author(s): Morten Beck Rye, Sebastian Krossa, Martina Hall, Casper van Mourik, Tone F. Bathen, Finn Drabløs, May-Britt Tessem, Helena Bertilsson,
Published in: iScience, 2022, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2022.104451

Spatial integration of multi-omics data from serial sections using the novel Multi-Omics Imaging Integration Toolset

Author(s): Maximilian Wess, Maria K Andersen, Elise Midtbust, Juan Carlos Cabellos Guillem, Trond Viset, Øystein Størkersen, Sebastian Krossa, Morten Beck Rye, May-Britt Tessem
Published in: GigaScience, Issue 14, 2025, ISSN 2047-217X
Publisher: Oxford University Press (OUP)
DOI: 10.1093/gigascience/giaf035

Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy

Author(s): Ailin Falkmo Hansen; Therese Stork Høiem; Kirsten Margrete Selnæs; Anna Mary Bofin; Øystein Størkersen; Helena Bertilsson; Alan J. Wright; Guro Fanneløb Giskeødegård; Tone Frost Bathen; Morten Beck Rye; May‐Britt Tessem
Published in: NMR Biomed, Issue 1, 2022, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4694

Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI

Author(s): Maria K. Andersen, Therese S. Høiem, Britt S. R. Claes, Benjamin Balluff, Marta Martin-Lorenzo, Elin Richardsen, Sebastian Krossa, Helena Bertilsson, Ron M. A. Heeren, Morten B. Rye, Guro F. Giskeødegård, Tone F. Bathen, May-Britt Tessem
Published in: Cancer & Metabolism, Issue 9/1, 2021, ISSN 2049-3002
Publisher: BMC Springer NAture
DOI: 10.1186/s40170-021-00242-z

A simple preparation protocol for shipping and storage of tissue sections for laser ablation-inductively coupled plasma-mass spectrometry imaging

Author(s): Rebecca Buchholz, Sebastian Krossa, Maria K Andersen, Michael Holtkamp, Michael Sperling, Uwe Karst, May-Britt Tessem
Published in: Metallomics, Issue 17565901, 2022, ISSN 1756-5901
Publisher: Royal Society of Chemistry
DOI: 10.1093/mtomcs/mfac013

A0948 - Multiomics spatial mapping of lipid metabolism in prostate cancer

Author(s): M.K. Andersen, S. Krossa, M. Elise, T. Viset, Ø. Størkersen, G.F. Giskeødegård, M.B. Rye, M-B. Tessem
Published in: European Urology, 2022, ISSN 0302-2838
Publisher: Elsevier BV
DOI: 10.1016/s0302-2838(22)01023-5

FunHoP analysis reveals upregulation of mitochondrial genes in prostate cancer

Author(s): Kjersti Rise; May-Britt Tessem; Finn Drabløs; Morten Beck Rye
Published in: e0275621-?, Issue 1, 2022, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0275621

Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer

Author(s): Antti Kiviaho, Sini K. Eerola, Heini M. L. Kallio, Maria K. Andersen, Miina Hoikka, Aliisa M. Tiihonen, Iida Salonen, Xander Spotbeen, Alexander Giesen, Charles T. A. Parker, Sinja Taavitsainen, Olli Hantula, Mikael Marttinen, Ismaïl Hermelo, Mazlina Ismail, Elise Midtbust, Maximilian Wess, Wout Devlies, Abhibhav Sharma, Sebastian Krossa, Tomi Häkkinen, Ebrahim Afyounian, Katy Vandereyken, Sam K
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-54364-1

Integrative metabolic and transcriptomic profiling of prostate cancer tissue containing reactive stroma

Author(s): Maria K. Andersen, Kjersti Rise, Guro F. Giskeødegård, Elin Richardsen, Helena Bertilsson, Øystein Størkersen, Tone F. Bathen, Morten Rye, May-Britt Tessem
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-32549-1

The effect of sampling procedures and day-to-day variations in metabolomics studies of biofluids

Author(s): Guro F. Giskeødegård, Trygve Andreassen, Helena Bertilsson, May-Britt Tessem, Tone F. Bathen
Published in: Analytica Chimica Acta, Issue 1081, 2019, Page(s) 93-102, ISSN 0003-2670
Publisher: Elsevier BV
DOI: 10.1016/j.aca.2019.07.026

NMR-based metabolomics of biofluids in cancer

Author(s): Guro F. Giskeødegård, Torfinn S. Madssen, Leslie R. Euceda, May-Britt Tessem, Siver A. Moestue, Tone F. Bathen
Published in: NMR in Biomedicine, 2018, Page(s) e3927, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.3927

Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue

Author(s): Maria K. Andersen, Sebastian Krossa, Therese S. Høiem, Rebecca Buchholz, Britt S. R. Claes, Benjamin Balluff, Shane R. Ellis, Elin Richardsen, Helena Bertilsson, Ron M. A. Heeren, Tone F. Bathen, Uwe Karst, Guro F. Giskeødegård, May-Britt Tessem
Published in: Analytical Chemistry, Issue 92/4, 2020, Page(s) 3171-3179, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.9b04903

Metabolic alterations in tissues and biofluids of patients with prostate cancer

Author(s): Maria K. Andersen, Guro F. Giskeødegård, May-Britt Tessem
Published in: Current Opinion in Endocrine and Metabolic Research, Issue 10, 2020, Page(s) 23-28, ISSN 2451-9650
Publisher: Elsevier
DOI: 10.1016/j.coemr.2020.02.003

An optimized MALDI MSI protocol for spatial detection of tryptic peptides in fresh frozen prostate tissue

Author(s): Therese S. Høiem; Maria K. Andersen; Marta Martin‐Lorenzo; Rémi Longuespée; Britt S.R. Claes; Anna Nordborg; Frédéric Dewez; Benjamin Balluff; Marco Giampà; Animesh Sharma; Lars Hagen; Ron M.A. Heeren; Tone F. Bathen; Guro F. Giskeødegård; Sebastian Krossa; May‐Britt Tessem
Published in: VOLUME=22;ISSUE=10;ISSN=1615-9853;TITLE=Proteomics, Issue 1, 2022, ISSN 1615-9853
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.202100223

A0942 - DNA methylation aberrations predicts recurrence both in tumor and normal appearing prostate tissue

Author(s): C. Pedersen, E. Midtbust, S. Krossa, M.K. Andersen, T. Viset, Ø. Størkersen, G.F. Giskeødegård, M.B. Rye, M-B. Tessem
Published in: European Urology, 2022, ISSN 0302-2838
Publisher: Elsevier BV
DOI: 10.1016/s0302-2838(22)01017-x

Book chapters (3)

Sample Preparation for Metabolite Detection in Mass Spectrometry Imaging

Author(s): Maria K. Andersen, Marco Giampà, Elise Midtbust, Therese S. Høiem, Sebastian Krossa, May-Britt Tessem
Published in: Methods in Molecular Biology, Imaging Mass Spectrometry, 2023, Page(s) 135-146
Publisher: Springer US
DOI: 10.1007/978-1-0716-3319-9_12

Biomarker Discovery Using NMR-Based Metabolomics of Tissue

Author(s): Maria T. Grinde, Guro F. Giskeødegård, Trygve Andreassen, May-Britt Tessem, Tone F. Bathen, Siver A. Moestue
Published in: NMR-Based Metabolomics - Methods and Protocols, Issue 2037, 2019, Page(s) 243-262, ISBN 978-1-4939-9689-6
Publisher: Springer New York
DOI: 10.1007/978-1-4939-9690-2_15

NMR-Based Prostate Cancer Metabolomics

Author(s): Leslie R. Euceda, Maria K. Andersen, May-Britt Tessem, Siver A. Moestue, Maria T. Grinde, Tone F. Bathen
Published in: Prostate Cancer, Issue 1786, 2018, Page(s) 237-257, ISBN 978-1-4939-7843-4
Publisher: Springer New York
DOI: 10.1007/978-1-4939-7845-8_14

Other (4)

Additional file 1 of DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival

Author(s): Pedersen, Christine Aaserød; Cao, Maria Dung; Fleischer, Thomas; Rye, Morten B.; Knappskog, Stian; Eikesdal, Hans Petter; Lønning, Per Eystein; Tost, Jörg; Kristensen, Vessela N.; Tessem, May-Britt; Giskeødegård, Guro F.; Bathen, Tone F.
Published in: Breast Cancer Research, Issue 2, 2022, ISSN 1465-542X
Publisher: Springe Nature
DOI: 10.6084/m9.figshare.20155587

Spatial Integration of Multi-Omics Data using the novel Multi-Omics Imaging Integration Toolset

Author(s): Maximillian Wess, Maria K. Andersen, Elise Midtbust, Juan Carlos Cabellos Guillem, Trond Viset, Øystein Størkersen, Sebastian Krossa, Morten Beck Rye, May-Britt Tessem
Published in: Bioarchive-the preprint of biology, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.06.11.598306

Additional file 1 of Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI

Author(s): Andersen, Maria K.; Høiem, Therese S.; Claes, Britt S. R.; Balluff, Benjamin; Martin-Lorenzo, Marta; Richardsen, Elin; Krossa, Sebastian; Bertilsson, Helena; Heeren, Ron M. A.; Rye, Morten B.; Giskeødegård, Guro F.; Bathen, Tone F.; May-Britt Tessem
Published in: CAncer and metabolism, Issue 1, 2021, ISSN 2049-3002
Publisher: Springer NAture
DOI: 10.6084/m9.figshare.13668033.v1

Deep phenotyping of the prostate tumor microenvironment reveals molecular stratifiers of relapse linked to inflammatory chemokine expression and aberrant metabolism

Author(s): Sebastian Krossa, Maria K. Andersen, Elise Midtbust, Maximilian Wess, Antti Kiviaho, Abhibhav Sharma, Trond Viset, Øystein Størkersen, Guro F. Giskeødegård, Matti Nykter, Alfonso Urbanucci, Morten B. Rye, May-Britt Tessem
Published in: Bioarchives-the preprent server for biology, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.05.13.593822