'Tissue is the issue': a multi-omics approach to improve prostate cancer diagnosis

Información del proyecto

ProstOmics

Identificador del acuerdo de subvención: 758306

DOI

10.3030/758306

Proyecto cerrado

Fecha de la firma de la CE 23 Enero 2018

Fecha de inicio 1 Febrero 2018

Fecha de finalización 30 Septiembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 500 000,00

Aportación de la UE

€ 1 500 000,00

Coordinado por

NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Conference proceedings (3)

A0948 - Multiomics spatial mapping of lipid metabolism in prostate cancer

Autores: M.K. Andersen, S. Krossa, M. Elise, T. Viset, Ø. Størkersen, G.F. Giskeødegård, M.B. Rye, M-B. Tessem
Publicado en: European Urology, Edición 1, 2022
Editor: Elsevier

A0942 - DNA methylation aberrations predicts recurrence both in tumor and normal appearing prostate tissue

Autores: C. Pedersen, E. Midtbust, S. Krossa, M.K. Andersen, T. Viset, Ø. Størkersen, G.F. Giskeødegård, M.B. Rye, M-B. Tessem
Publicado en: European Urology, Edición 1, 2022
Editor: Elsevier

A0950 - Inflammatory chemokines upregulated in the tumor microenvironment of prostate cancer patients experiencing relapse after radical prostatectomy

Autores: S. Krossa, M.K. Andersen, E. Midtbust, T. Viset, Ø. Størkersen, G.F. Giskeødegård, M.B. Rye, M-B. Tessem,
Publicado en: European Urology, Edición 1, 2022
Editor: Elsivier

Peer reviewed articles (19)

A0950 - Inflammatory chemokines upregulated in the tumor microenvironment of prostate cancer patients experiencing relapse after radical prostatectomy

Autores: S. Krossa, M.K. Andersen, E. Midtbust, T. Viset, Ø. Størkersen, G.F. Giskeødegård, M.B. Rye, M-B. Tessem,
Publicado en: European Urology, 2022, ISSN 0302-2838
Editor: Elsevier BV
DOI: 10.1016/s0302-2838(22)01025-9

Spatial transcriptomics reveals strong association between SFRP4 and extracellular matrix remodeling in prostate cancer

Autores: Maria K. Andersen, Sebastian Krossa, Elise Midtbust, Christine A. Pedersen, Maximilian Wess, Therese S. Høiem, Trond Viset, Øystein Størkersen, Ingunn Nervik, Elise Sandsmark, Helena Bertilsson, Guro F. Giskeødegård, Morten B. Rye, May-Britt Tessem
Publicado en: Communications Biology, Edición 7, 2024, ISSN 2399-3642
Editor: Nature portfolio
DOI: 10.1038/s42003-024-07161-x

DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival

Autores: Christine Aaserød Pedersen; Maria Dung Cao; Thomas Fleischer; Morten B. Rye; Stian Knappskog; Hans Petter Eikesdal; Per Eystein Lønning; Jörg Tost; Vessela N. Kristensen; May-Britt Tessem; Guro F. Giskeødegård; Tone F. Bathen
Publicado en: Breast cancer Research, Edición 1, 2022, ISSN 1465-542X
Editor: Springer NAture
DOI: 10.1186/s13058-022-01537-9

FunHoP: Enhanced Visualization and Analysis of Functionally Homologous Proteins in Complex Metabolic Networks

Autores: Kjersti Rise, May-Britt Tessem, Finn Drabløs, Morten B. Rye
Publicado en: Genomics, Proteomics & Bioinformatics, Edición 19, 2024, Página(s) 848-859, ISSN 1672-0229
Editor: Kexue Chubaneshe/Science Press
DOI: 10.1016/j.gpb.2021.03.003

The genes controlling normal function of citrate and spermine secretion are lost in aggressive prostate cancer and prostate model systems

Autores: Morten Beck Rye, Sebastian Krossa, Martina Hall, Casper van Mourik, Tone F. Bathen, Finn Drabløs, May-Britt Tessem, Helena Bertilsson,
Publicado en: iScience, 2022, ISSN 2589-0042
Editor: Elsevier
DOI: 10.1016/j.isci.2022.104451

Spatial integration of multi-omics data from serial sections using the novel Multi-Omics Imaging Integration Toolset

Autores: Maximilian Wess, Maria K Andersen, Elise Midtbust, Juan Carlos Cabellos Guillem, Trond Viset, Øystein Størkersen, Sebastian Krossa, Morten Beck Rye, May-Britt Tessem
Publicado en: GigaScience, Edición 14, 2025, ISSN 2047-217X
Editor: Oxford University Press (OUP)
DOI: 10.1093/gigascience/giaf035

Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy

Autores: Ailin Falkmo Hansen; Therese Stork Høiem; Kirsten Margrete Selnæs; Anna Mary Bofin; Øystein Størkersen; Helena Bertilsson; Alan J. Wright; Guro Fanneløb Giskeødegård; Tone Frost Bathen; Morten Beck Rye; May‐Britt Tessem
Publicado en: NMR Biomed, Edición 1, 2022, ISSN 0952-3480
Editor: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4694

Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI

Autores: Maria K. Andersen, Therese S. Høiem, Britt S. R. Claes, Benjamin Balluff, Marta Martin-Lorenzo, Elin Richardsen, Sebastian Krossa, Helena Bertilsson, Ron M. A. Heeren, Morten B. Rye, Guro F. Giskeødegård, Tone F. Bathen, May-Britt Tessem
Publicado en: Cancer & Metabolism, Edición 9/1, 2021, ISSN 2049-3002
Editor: BMC Springer NAture
DOI: 10.1186/s40170-021-00242-z

A simple preparation protocol for shipping and storage of tissue sections for laser ablation-inductively coupled plasma-mass spectrometry imaging

Autores: Rebecca Buchholz, Sebastian Krossa, Maria K Andersen, Michael Holtkamp, Michael Sperling, Uwe Karst, May-Britt Tessem
Publicado en: Metallomics, Edición 17565901, 2022, ISSN 1756-5901
Editor: Royal Society of Chemistry
DOI: 10.1093/mtomcs/mfac013

A0948 - Multiomics spatial mapping of lipid metabolism in prostate cancer

Autores: M.K. Andersen, S. Krossa, M. Elise, T. Viset, Ø. Størkersen, G.F. Giskeødegård, M.B. Rye, M-B. Tessem
Publicado en: European Urology, 2022, ISSN 0302-2838
Editor: Elsevier BV
DOI: 10.1016/s0302-2838(22)01023-5

FunHoP analysis reveals upregulation of mitochondrial genes in prostate cancer

Autores: Kjersti Rise; May-Britt Tessem; Finn Drabløs; Morten Beck Rye
Publicado en: e0275621-?, Edición 1, 2022, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0275621

Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer

Autores: Antti Kiviaho, Sini K. Eerola, Heini M. L. Kallio, Maria K. Andersen, Miina Hoikka, Aliisa M. Tiihonen, Iida Salonen, Xander Spotbeen, Alexander Giesen, Charles T. A. Parker, Sinja Taavitsainen, Olli Hantula, Mikael Marttinen, Ismaïl Hermelo, Mazlina Ismail, Elise Midtbust, Maximilian Wess, Wout Devlies, Abhibhav Sharma, Sebastian Krossa, Tomi Häkkinen, Ebrahim Afyounian, Katy Vandereyken, Sam K
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-54364-1

Integrative metabolic and transcriptomic profiling of prostate cancer tissue containing reactive stroma

Autores: Maria K. Andersen, Kjersti Rise, Guro F. Giskeødegård, Elin Richardsen, Helena Bertilsson, Øystein Størkersen, Tone F. Bathen, Morten Rye, May-Britt Tessem
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-32549-1

The effect of sampling procedures and day-to-day variations in metabolomics studies of biofluids

Autores: Guro F. Giskeødegård, Trygve Andreassen, Helena Bertilsson, May-Britt Tessem, Tone F. Bathen
Publicado en: Analytica Chimica Acta, Edición 1081, 2019, Página(s) 93-102, ISSN 0003-2670
Editor: Elsevier BV
DOI: 10.1016/j.aca.2019.07.026

NMR-based metabolomics of biofluids in cancer

Autores: Guro F. Giskeødegård, Torfinn S. Madssen, Leslie R. Euceda, May-Britt Tessem, Siver A. Moestue, Tone F. Bathen
Publicado en: NMR in Biomedicine, 2018, Página(s) e3927, ISSN 0952-3480
Editor: John Wiley & Sons Inc.
DOI: 10.1002/nbm.3927

Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue

Autores: Maria K. Andersen, Sebastian Krossa, Therese S. Høiem, Rebecca Buchholz, Britt S. R. Claes, Benjamin Balluff, Shane R. Ellis, Elin Richardsen, Helena Bertilsson, Ron M. A. Heeren, Tone F. Bathen, Uwe Karst, Guro F. Giskeødegård, May-Britt Tessem
Publicado en: Analytical Chemistry, Edición 92/4, 2020, Página(s) 3171-3179, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.9b04903

Metabolic alterations in tissues and biofluids of patients with prostate cancer

Autores: Maria K. Andersen, Guro F. Giskeødegård, May-Britt Tessem
Publicado en: Current Opinion in Endocrine and Metabolic Research, Edición 10, 2020, Página(s) 23-28, ISSN 2451-9650
Editor: Elsevier
DOI: 10.1016/j.coemr.2020.02.003

An optimized MALDI MSI protocol for spatial detection of tryptic peptides in fresh frozen prostate tissue

Autores: Therese S. Høiem; Maria K. Andersen; Marta Martin‐Lorenzo; Rémi Longuespée; Britt S.R. Claes; Anna Nordborg; Frédéric Dewez; Benjamin Balluff; Marco Giampà; Animesh Sharma; Lars Hagen; Ron M.A. Heeren; Tone F. Bathen; Guro F. Giskeødegård; Sebastian Krossa; May‐Britt Tessem
Publicado en: VOLUME=22;ISSUE=10;ISSN=1615-9853;TITLE=Proteomics, Edición 1, 2022, ISSN 1615-9853
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.202100223

A0942 - DNA methylation aberrations predicts recurrence both in tumor and normal appearing prostate tissue

Autores: C. Pedersen, E. Midtbust, S. Krossa, M.K. Andersen, T. Viset, Ø. Størkersen, G.F. Giskeødegård, M.B. Rye, M-B. Tessem
Publicado en: European Urology, 2022, ISSN 0302-2838
Editor: Elsevier BV
DOI: 10.1016/s0302-2838(22)01017-x

Book chapters (3)

Sample Preparation for Metabolite Detection in Mass Spectrometry Imaging

Autores: Maria K. Andersen, Marco Giampà, Elise Midtbust, Therese S. Høiem, Sebastian Krossa, May-Britt Tessem
Publicado en: Methods in Molecular Biology, Imaging Mass Spectrometry, 2023, Página(s) 135-146
Editor: Springer US
DOI: 10.1007/978-1-0716-3319-9_12

Biomarker Discovery Using NMR-Based Metabolomics of Tissue

Autores: Maria T. Grinde, Guro F. Giskeødegård, Trygve Andreassen, May-Britt Tessem, Tone F. Bathen, Siver A. Moestue
Publicado en: NMR-Based Metabolomics - Methods and Protocols, Edición 2037, 2019, Página(s) 243-262, ISBN 978-1-4939-9689-6
Editor: Springer New York
DOI: 10.1007/978-1-4939-9690-2_15

NMR-Based Prostate Cancer Metabolomics

Autores: Leslie R. Euceda, Maria K. Andersen, May-Britt Tessem, Siver A. Moestue, Maria T. Grinde, Tone F. Bathen
Publicado en: Prostate Cancer, Edición 1786, 2018, Página(s) 237-257, ISBN 978-1-4939-7843-4
Editor: Springer New York
DOI: 10.1007/978-1-4939-7845-8_14

Other (4)

Additional file 1 of DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival

Autores: Pedersen, Christine Aaserød; Cao, Maria Dung; Fleischer, Thomas; Rye, Morten B.; Knappskog, Stian; Eikesdal, Hans Petter; Lønning, Per Eystein; Tost, Jörg; Kristensen, Vessela N.; Tessem, May-Britt; Giskeødegård, Guro F.; Bathen, Tone F.
Publicado en: Breast Cancer Research, Edición 2, 2022, ISSN 1465-542X
Editor: Springe Nature
DOI: 10.6084/m9.figshare.20155587

Spatial Integration of Multi-Omics Data using the novel Multi-Omics Imaging Integration Toolset

Autores: Maximillian Wess, Maria K. Andersen, Elise Midtbust, Juan Carlos Cabellos Guillem, Trond Viset, Øystein Størkersen, Sebastian Krossa, Morten Beck Rye, May-Britt Tessem
Publicado en: Bioarchive-the preprint of biology, 2024
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.06.11.598306

Additional file 1 of Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI

Autores: Andersen, Maria K.; Høiem, Therese S.; Claes, Britt S. R.; Balluff, Benjamin; Martin-Lorenzo, Marta; Richardsen, Elin; Krossa, Sebastian; Bertilsson, Helena; Heeren, Ron M. A.; Rye, Morten B.; Giskeødegård, Guro F.; Bathen, Tone F.; May-Britt Tessem
Publicado en: CAncer and metabolism, Edición 1, 2021, ISSN 2049-3002
Editor: Springer NAture
DOI: 10.6084/m9.figshare.13668033.v1

Deep phenotyping of the prostate tumor microenvironment reveals molecular stratifiers of relapse linked to inflammatory chemokine expression and aberrant metabolism

Autores: Sebastian Krossa, Maria K. Andersen, Elise Midtbust, Maximilian Wess, Antti Kiviaho, Abhibhav Sharma, Trond Viset, Øystein Størkersen, Guro F. Giskeødegård, Matti Nykter, Alfonso Urbanucci, Morten B. Rye, May-Britt Tessem
Publicado en: Bioarchives-the preprent server for biology, 2024
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.05.13.593822