Reconstructing human cortex development and malformation with single-cell transcriptomics

Project Information

ORGANOMICS

Grant agreement ID: 758877

DOI

10.3030/758877

Project closed

EC signature date 12 December 2017

Start date 1 January 2018

End date 30 June 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

Human organomics: a fresh approach to understanding human development using single-cell transcriptomics

Author(s): J. Gray Camp, Barbara Treutlein
Published in: Development, Issue 144/9, 2017, Page(s) 1584-1587, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.150458

Mapping human cell phenotypes to genotypes with single-cell genomics

Author(s): J. Gray Camp, Randall Platt, Barbara Treutlein
Published in: Science, Issue 365/6460, 2019, Page(s) 1401-1405, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax6648

Multimodal spatiotemporal phenotyping of human retinal organoid development

Author(s): Philipp Wahle; Giovanna Brancati; Christoph Harmel; Zhisong He; Gabriele Gut; Jacobo Sarabia del Castillo; Aline Xavier da Silveira dos Santos; Qianhui Yu; Pascal Noser; Jonas Simon Fleck; Bruno Gjeta; Dinko Pavlinić; Simone Picelli; Max Hess; Gregor W. Schmidt; Tom T. A. Lummen; Yanyan Hou; Patricia Galliker; David Goldblum; Marton Balogh; Cameron S. Cowan; Hendrik P. N. Scholl; Botond Roska; Ma
Published in: Nature Biotechnology, Issue 9, 2023, ISSN 1546-1696
Publisher: Nature Publishing group
DOI: 10.1038/s41587-023-01747-2

Inferring and perturbing cell fate regulomes in human brain organoids

Author(s): Fleck, Jonas Simon Jansen, Sophie Martina Johanna Wollny, Damian Zenk, Fides Seimiya, Makiko Jain, Akanksha Okamoto, Ryoko Santel, Malgorzata He, Zhisong Camp, J. Gray Treutlein, Barbara
Published in: Nature, 2022, ISSN 1476-4687
Publisher: NAture Publishing Group
DOI: 10.1038/s41586-022-05279-8

Single-cell brain organoid screening identifies developmental defects in autism

Author(s): Li, Chong Fleck, Jonas Simon Martins-Costa, Catarina Burkard, Thomas R. Themann, Jan Stuempflen, Marlene Peer, Angela Maria Vertesy, Ábel Littleboy, Jamie B. Esk, Christopher Elling, Ulrich Kasprian, Gregor Corsini, Nina S. Treutlein, Barbara Knoblich, Juergen A.
Published in: Nature, 2023, ISSN 1476-4687
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-06473-y

Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia

Author(s): Johannes Klaus, Sabina Kanton, Christina Kyrousi, Ane Cristina Ayo-Martin, Rossella Di Giaimo, Stephan Riesenberg, Adam C O'Neill, J Gray Camp, Chiara Tocco, Malgorzata Santel, Ejona Rusha, Micha Drukker, Mariana Schroeder, Magdalena Götz, Stephen P Robertson, Barbara Treutlein, Silvia Cappello
Published in: Nature Medicine, 2019, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0371-0

Lineage recording in human cerebral organoids

Author(s): Zhisong He; Ashley Maynard; Akanksha Jain; Tobias Gerber; Rebecca Petri; Hsiu-Chuan Lin; Malgorzata Santel; Kevin Ly; Jean-Samuel Dupré; Leila Sidow; Fatima Sanchis Calleja; Sophie M. J. Jansen; Stephan Riesenberg; J. Gray Camp; Barbara Treutlein
Published in: Nature Methods, Issue 12, 2021, ISSN 1548-7105
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-021-01344-8

Single-cell genomics to guide human stem cell and tissue engineering

Author(s): J. Gray Camp, Damian Wollny, Barbara Treutlein
Published in: Nature Methods, Issue 15/9, 2018, Page(s) 661-667, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-018-0113-0

Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program

Author(s): Marisa Karow, J. Gray Camp, Sven Falk, Tobias Gerber, Abhijeet Pataskar, Malgorzata Gac-Santel, Jorge Kageyama, Agnieska Brazovskaja, Angela Garding, Wenqiang Fan, Therese Riedemann, Antonella Casamassa, Andrej Smiyakin, Christian Schichor, Magdalena Götz, Vijay K. Tiwari, Barbara Treutlein, Benedikt Berninger
Published in: Nature Neuroscience, Issue 21/7, 2018, Page(s) 932-940, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-018-0168-3

Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration

Author(s): Tobias Gerber, Prayag Murawala, Dunja Knapp, Wouter Masselink, Maritta Schuez, Sarah Hermann, Malgorzata Gac-Santel, Sergej Nowoshilow, Jorge Kageyama, Shahryar Khattak, Joshua D. Currie, J. Gray Camp, Elly M. Tanaka, Barbara Treutlein
Published in: Science, Issue 362/6413, 2018, Page(s) eaaq0681, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaq0681

What is a cell type?

Author(s): Fleck, Jonas Simon; Camp, J. Gray; Treutlein, Barbara; id_orcid0000-0002-3299-5597
Published in: Science, 381 (6659), Issue 4, 2023, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adf6162

Charting human development using a multi-endodermal organ atlas and organoid models

Author(s): Qianhui Yu; Umut Kilik; Emily M. Holloway; Yu-Hwai Tsai; Christoph Harmel; Angeline Wu; Joshua H. Wu; Michael Czerwinski; Charlie Childs; Zhisong He; Meghan M. Capeling; Sha Huang; Ian A. Glass; Peter D.R. Higgins; Barbara Treutlein; Jason R. Spence; J. Gray Camp
Published in: Cell, 184 (12), Issue 4, 2021, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.04.028

Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases

Author(s): Fleck, Jonas S. Sanchís-Calleja, Fátima He, Zhisong Santel, Malgorzata Boyle, Michael J. Camp, J. Gray Treutlein, Barbara
Published in: Cell Stem Cell, 2021, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2021.02.015

Resolving Neurodevelopmental and Vision Disorders Using Organoid Single-Cell Multi-omics

Author(s): Giovanna Brancati, Barbara Treutlein, J. Gray Camp
Published in: Neuron, Issue 107/6, 2020, Page(s) 1000-1013, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.09.001

CSS: cluster similarity spectrum integration of single-cell genomics data

Author(s): Zhisong He, Agnieska Brazovskaja, Sebastian Ebert, J. Gray Camp, Barbara Treutlein
Published in: Genome Biology, Issue 21/1, 2020, ISSN 1474-760X
Publisher: BMC Genome Biology
DOI: 10.1186/s13059-020-02147-4

Organoid single-cell genomic atlas uncovers human-specific features of brain development

Author(s): Sabina Kanton, Michael James Boyle, Zhisong He, Malgorzata Santel, Anne Weigert, Fátima Sanchís-Calleja, Patricia Guijarro, Leila Sidow, Jonas Simon Fleck, Dingding Han, Zhengzong Qian, Michael Heide, Wieland B. Huttner, Philipp Khaitovich, Svante Pääbo, Barbara Treutlein, J. Gray Camp
Published in: Nature, Issue 574/7778, 2019, Page(s) 418-422, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1654-9

Other (1)

Lineage recording reveals dynamics of cerebral organoid regionalization

Author(s): Zhisong He, Tobias Gerber, Ashley Maynard, Akanksha Jain, Rebecca Petri, Malgorzata Santel, Kevin Ly, Leila Sidow, Fatima Sanchis Callejal, Stephan Riesenberg, J. Gray Camp, Barbara Treutlein
Published in: bioRxiv, 2020
Publisher: www.biorxiv.org
DOI: 10.1101/2020.06.19.162032

Book chapters (1)

Single-cell genomic analysis of human cerebral organoids

Author(s): Sabina Kanton, Barbara Treutlein, J. Gray Camp
Published in: Human Pluripotent Stem Cell Derived Organoid Models, Issue 159, 2020, Page(s) 229-256, ISBN 9780128215319
Publisher: Elsevier
DOI: 10.1016/bs.mcb.2020.03.013