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Biophysical mechanisms of long-range transcriptional regulation

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Publications

DamC reveals principles of chromatin folding in vivo without crosslinking and ligation

Author(s): Josef Redolfi, Yinxiu Zhan, Christian Valdes-Quezada, Mariya Kryzhanovska, Isabel Guerreiro, Vytautas Iesmantavicius, Tim Pollex, Ralph S. Grand, Eskeatnaf Mulugeta, Jop Kind, Guido Tiana, Sebastien A. Smallwood, Wouter de Laat, Luca Giorgetti
Published in: Nature Structural & Molecular Biology, Issue 26/6, 2019, Page(s) 471-480, ISSN 1545-9993
DOI: 10.1038/s41594-019-0231-0

The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist

Author(s): Joke G. van Bemmel, Rafael Galupa, Chris Gard, Nicolas Servant, Christel Picard, James Davies, Anthony James Szempruch, Yinxiu Zhan, Jan J. Żylicz, Elphège P. Nora, Sonia Lameiras, Elzo de Wit, David Gentien, Sylvain Baulande, Luca Giorgetti, Mitchell Guttman, Jim R. Hughes, Douglas R. Higgs, Joost Gribnau, Edith Heard
Published in: Nature Genetics, Issue 51/6, 2019, Page(s) 1024-1034, ISSN 1061-4036
DOI: 10.1038/s41588-019-0412-0

A symmetric toggle switch explains the onset of random X inactivation in different mammals

Author(s): Verena Mutzel, Ikuhiro Okamoto, Ilona Dunkel, Mitinori Saitou, Luca Giorgetti, Edith Heard, Edda G. Schulz
Published in: Nature Structural & Molecular Biology, Issue 26/5, 2019, Page(s) 350-360, ISSN 1545-9993
DOI: 10.1038/s41594-019-0214-1

A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary

Author(s): Rafael Galupa, Elphège Pierre Nora, Rebecca Worsley-Hunt, Christel Picard, Chris Gard, Joke Gerarda van Bemmel, Nicolas Servant, Yinxiu Zhan, Fatima El Marjou, Colin Johanneau, Patricia Diabangouaya, Agnès Le Saux, Sonia Lameiras, Juliana Pipoli da Fonseca, Friedemann Loos, Joost Gribnau, Sylvain Baulande, Uwe Ohler, Luca Giorgetti, Edith Heard
Published in: Molecular Cell, Issue 77/2, 2020, Page(s) 352-367.e8, ISSN 1097-2765
DOI: 10.1016/j.molcel.2019.10.030

Chromosome Conformation Capture and Beyond: Toward an Integrative View of Chromosome Structure and Function

Author(s): Rachel Patton McCord, Noam Kaplan, Luca Giorgetti
Published in: Molecular Cell, Issue 77/4, 2020, Page(s) 688-708, ISSN 1097-2765
DOI: 10.1016/j.molcel.2019.12.021