Biophysical mechanisms of long-range transcriptional regulation

Project Information

BioMeTRe

Grant agreement ID: 759366

DOI

10.3030/759366

Project closed

EC signature date 4 September 2017

Start date 1 January 2018

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Cohesin and CTCF control the dynamics of chromosome folding

Author(s): Pia Mach, Pavel I. Kos, Yinxiu Zhan, Julie Cramard, Simon Gaudin, Jana Tünnermann, Edoardo Marchi, Jan Eglinger, Jessica Zuin, Mariya Kryzhanovska, Sebastien Smallwood, Laurent Gelman, Gregory Roth, Elphège P. Nora, Guido Tiana & Luca Giorgetti
Published in: Nature Genetics, 2022, ISSN 1061-4036
Publisher: Nature Publishing Group

deepBlink: Threshold-independent detection and localization of diffraction-limited spots

Author(s): Bastian Th. Eichenberger; Bastian Th. Eichenberger; Yinxiu Zhan; Markus Rempfler; Luca Giorgetti; Jeffrey A. Chao
Published in: Nucleic Acids Research, Issue 2, 2021, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1101/2020.12.14.422631

DamC reveals principles of chromatin folding in vivo without crosslinking and ligation

Author(s): Josef Redolfi, Yinxiu Zhan, Christian Valdes-Quezada, Mariya Kryzhanovska, Isabel Guerreiro, Vytautas Iesmantavicius, Tim Pollex, Ralph S. Grand, Eskeatnaf Mulugeta, Jop Kind, Guido Tiana, Sebastien A. Smallwood, Wouter de Laat, Luca Giorgetti
Published in: Nature Structural & Molecular Biology, Issue 26/6, 2019, Page(s) 471-480, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-019-0231-0

The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist

Author(s): Joke G. van Bemmel, Rafael Galupa, Chris Gard, Nicolas Servant, Christel Picard, James Davies, Anthony James Szempruch, Yinxiu Zhan, Jan J. Żylicz, Elphège P. Nora, Sonia Lameiras, Elzo de Wit, David Gentien, Sylvain Baulande, Luca Giorgetti, Mitchell Guttman, Jim R. Hughes, Douglas R. Higgs, Joost Gribnau, Edith Heard
Published in: Nature Genetics, Issue 51/6, 2019, Page(s) 1024-1034, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-019-0412-0

A symmetric toggle switch explains the onset of random X inactivation in different mammals

Author(s): Verena Mutzel, Ikuhiro Okamoto, Ilona Dunkel, Mitinori Saitou, Luca Giorgetti, Edith Heard, Edda G. Schulz
Published in: Nature Structural & Molecular Biology, Issue 26/5, 2019, Page(s) 350-360, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-019-0214-1

A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary

Author(s): Rafael Galupa, Elphège Pierre Nora, Rebecca Worsley-Hunt, Christel Picard, Chris Gard, Joke Gerarda van Bemmel, Nicolas Servant, Yinxiu Zhan, Fatima El Marjou, Colin Johanneau, Patricia Diabangouaya, Agnès Le Saux, Sonia Lameiras, Juliana Pipoli da Fonseca, Friedemann Loos, Joost Gribnau, Sylvain Baulande, Uwe Ohler, Luca Giorgetti, Edith Heard
Published in: Molecular Cell, Issue 77/2, 2020, Page(s) 352-367.e8, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.10.030

Chromosome Conformation Capture and Beyond: Toward an Integrative View of Chromosome Structure and Function

Author(s): Rachel Patton McCord, Noam Kaplan, Luca Giorgetti
Published in: Molecular Cell, Issue 77/4, 2020, Page(s) 688-708, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.12.021

Challenges and guidelines toward 4D nucleome data and model standards

Author(s): Marc A. Marti-Renom, Genevieve Almouzni, Wendy A. Bickmore, Kerstin Bystricky, Giacomo Cavalli, Peter Fraser, Susan M. Gasser, Luca Giorgetti, Edith Heard, Mario Nicodemi, Marcelo Nollmann, Modesto Orozco, Ana Pombo & Maria-Elena Torres-Padilla
Published in: Nature Genetics, 2018, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-018-0236-3

HP1 drives de novo 3D genome reorganization in early Drosophila embryos

Author(s): Fides Zenk, Yinxiu Zhan, Pavel Kos, Eva Löser, Nazerke Atinbayeva, Melanie Schächtle, Guido Tiana, Luca Giorgetti & Nicola Iovino
Published in: Nature, 2021, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03460-z

Integrative approaches to study enhancer–promoter communication

Author(s): Pia Mach, Luca Giorgetti
Published in: Current Opinion in Genetics & Development, 2023, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2023.102052

Integrating experiment, theory and simulation to determine the structure and dynamics of mammalian chromosomes

Author(s): g tiana, l giorgetti
Published in: Elsevier, 2017, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2017.10.016

Nonlinear control of transcription through enhancer–promoter interactions

Author(s): Jessica Zuin; Gregory Roth; Yinxiu Zhan; Julie Cramard; Josef Redolfi; Ewa Piskadlo; Pia Mach; Mariya Kryzhanovska; Gergely Tihanyi; Hubertus Kohler; Mathias Eder; Christ Leemans; Bas van Steensel; Peter Meister; Sebastien Smallwood; Luca Giorgetti
Published in: Zuin, Jessica; Roth, Gregory; Zhan, Yinxiu; Cramard, Julie; Redolfi, Josef; Piskadlo, Ewa; Mach, Pia; Kryzhanovska, Mariya; Tihanyi, Gergely; Kohler, Hubertus; Eder, Mathias; Leemans, Christ; van Steensel, Bas; Meister, Peter; Smallwood, Sebastien; Giorgetti, Luca (2022). Nonlinear control of transcription through enhancer-promoter interactions. Nature, 604(7906), pp. 571-577. Springer Nature 10.1, Issue 5, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04570-y