Targeting neuroinflammation to combat pathological pain in neurodegenerative diseases and chronic pain syndromes

Informazioni relative al progetto

TOBeATPAIN

ID dell’accordo di sovvenzione: 764860

DOI 10.3030/764860

Progetto chiuso

Data della firma CE 5 Luglio 2018

Data di avvio 1 Agosto 2018

Data di completamento 31 Luglio 2022

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale € 2 870 359,20

Contributo UE € 2 870 359,20

Coordinato da

KING'S COLLEGE LONDON
United Kingdom

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

Websites, patent fillings, videos etc. (1)

TOBeATPAIN Website

Documents, reports (3)

Dissemination & Communication Report II

Dissemination Communication Report

Dissemination & Communication Report I

Dissemination & Communication Report

Scientific papers in peer-reviewed journals

Scientific papers in peerreviewed journals

Other (1)

TOBeATPAIN Conference

Pubblicazioni

Peer reviewed articles (16)

Pain in the neurodegenerating brain: insights into pharmacotherapy for Alzheimer disease and Parkinson disease

Autori: Lawn, Timothy; Aman, Yahyah; Rukavina, Katarina; Sideris-Lampretsas, George; Howard, Matthew; Ballard, Clive; Ray Chaudhuri, Kallol; Malcangio, Marzia
Pubblicato in: PAIN, Numero 162, 2021, Pagina/e 999-1006, ISSN 0304-3959
Editore: Elsevier BV
DOI: 10.1097/j.pain.0000000000002111

Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls

Autori: Isabel Ellerbrock, Angelica Sandström, Jeanette Tour, Silvia Fanton, Diana Kadetoff, Martin Schalling, Karin B. Jensen, Rouslan Sitnikov, Eva Kosek
Pubblicato in: Molecular Brain, Numero 14/1, 2021, ISSN 1756-6606
Editore: BioMed Central
DOI: 10.1186/s13041-021-00789-4

Interactions of the neuropeptide galanin with cortical spreading depolarization and cortical neuronal excitability

Autori: Gimeno-Ferrer, F,; Eitner, A.; Bauer, R.; Lehmenkuhler, A.; Schaible, H-G.; Richter, F.
Pubblicato in: Journal of Headache and Pain, Numero 1, 2021, Pagina/e Vol 22 Numero Supp 1 pg 41, ISSN 1129-2377
Editore: Springer Nature
DOI: 10.5281/zenodo.6242314

From spreading depolarization to epilepsy with neuroinflammation: Therole of CGRP in cortex

Autori: Fatima Gimeno-Ferrer, Annett Eitner, Reinhard Bauer, Alfred Lehmenkühler, MarieLuise Edenhofer, Michaela Kress, Hans-Georg Schaible, Frank Richter
Pubblicato in: Experimental Neurology, Numero Vol 356,, 2022, ISSN 0014-4886
Editore: Academic Press
DOI: 10.1016/j.expneurol.2022.114152

Pain-Resolving Microglial

Autori: Sideris-Lampretsas, George, Malcangio, Marzia
Pubblicato in: SCIENCE, Numero Vol 376, Numeros 6588, 2022, Pagina/e 33-34, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abo5592

Role of the immune system in neuropathic pain

Autori: Marzia Malcangio
Pubblicato in: Scandinavian Journal of Pain, Numero 20/1, 2019, Pagina/e 33-37, ISSN 1877-8860
Editore: Elsevier BV
DOI: 10.1515/sjpain-2019-0138

The translocator protein gene is associated with endogenous pain modulation and the balance between glutamate and γ-aminobutyric acid in fibromyalgia and healthy subjects

Autori: Silvia Fanton, Angelica Sandström, Jeanette Tour, Diana Kadetoff, Martin Schalling, Karin B. Jensen, Rouslan Sitnikov, Isabel Ellerbrock, Eva Kosek
Pubblicato in: Pain, Numero Publish Ahead of Print, 2021, ISSN 0304-3959
Editore: Elsevier BV
DOI: 10.1097/j.pain.0000000000002309

Pain in Parkinson's disease: new concepts in pathogenesis and treatment

Autori: Katarina Rukavina, Valentina Leta, Carolina Sportelli, Yazead Buhidma, Susan Duty, Marzia Malcangio, Kallol Ray Chaudhuri
Pubblicato in: Current Opinion in Neurology, Numero 32, 2019, Pagina/e 579-588, ISSN 0951-7383
Editore: Lippincott Williams & Wilkins
DOI: 10.1097/wco.0000000000000711

Microglial heterogeneity in chronic pain

Autori: George Sideris-Lampretsas, Marzia Malcangio
Pubblicato in: Brain, Behavior, and Immunity, 2021, ISSN 0889-1591
Editore: Academic Press
DOI: 10.1016/j.bbi.2021.06.005

Translational value of preclinical models for rheumatoid arthritis pain

Autori: Marzia Malcangio
Pubblicato in: Pain, Numero 161/7, 2020, Pagina/e 1399-1400, ISSN 0304-3959
Editore: Elsevier BV
DOI: 10.1097/j.pain.0000000000001851

From the low-density lipoprotein receptor–related protein 1 to neuropathic pain: a potentially novel target

Autori: García-Fernández, Patricia; Üçeyler, Nurcan; Sommer, Claudia
Pubblicato in: PAIN Vol 6 Numero 1, Numero 1, 2021, Pagina/e 898, ISSN 2471-2531
Editore: IASP
DOI: 10.1097/PR9.0000000000000898

Animal models of Parkinson's disease: a guide to selecting the optimal model for your research

Autori: Lama, Joana; Buhidma, Yazead; Fletcher, Edward J.R.; Duty, Susan
Pubblicato in: Neuronal Signaling, Numero 2, 2021, Pagina/e Vol 5 Numero 4, ISSN 2059-6553
Editore: Portland Press
DOI: 10.1042/NS20210026

Multiple spatial scale mapping of time-resolved brain network reconfiguration during evoked pain in patients with rheumatoid arthritis

Autori: Silvia Fanton, Reem Altawil, Isabel Ellerbrock, Jon Lampa, Eva Kosek,Peter Fransson, William H. Thompson
Pubblicato in: Frontiers in Neuroscience, Numero 1662453X, 2022, ISSN 1662-453X
Editore: Frontiers in Neuroscience
DOI: 10.3389/fnins.2022.942136

Potential of animal models for advancing the understanding and treatment of pain in Parkinson’s disease

Autori: Yazead Buhidma, Katarina Rukavina, Kallol Ray Chaudhuri, Susan Duty
Pubblicato in: npj Parkinson's Disease, Numero 6/1, 2020, ISSN 2373-8057
Editore: https://www.nature.com/npjparkd/
DOI: 10.1038/s41531-019-0104-6

Passive transfer of fibromyalgia symptoms from patients to mice

Autori: Andreas Goebel; Emerson Krock; Clive Gentry; Mathilde R. Israel; Alexandra Jurczak; Carlos Morado Urbina; Katalin Sandor; Nisha Vastani; Margot Maurer; Ulku Cuhadar; Serena Sensi; Yuki Nomura; Joana Menezes; Azar Baharpoor; Louisa Brieskorn; Angelica Sandström; Jeanette Tour; Diana Kadetoff; Lisbet Haglund; Eva Kosek; Eva Kosek; Stuart Bevan; Camilla I. Svensson; David Andersson
Pubblicato in: JOURNAL OF CLINICAL INVESTIGATION, Numero 4, 2021, ISSN 1558-8238
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci144201

Fractalkine/CX3CR1 Pathway in Neuropathic Pain: An Update

Autori: Rita Silva, Marzia Malcangio
Pubblicato in: Frontiers in Pain Research, Numero Volume 2 - 2021, 2021, ISSN 2673-561X
Editore: Frontiers
DOI: 10.3389/fpain.2021.684684