Liver Spatial Omics

Informazioni relative al progetto

LSO

ID dell’accordo di sovvenzione: 768956

DOI

10.3030/768956

Progetto chiuso

Data della firma CE 22 Gennaio 2018

Data di avvio 1 Novembre 2018

Data di completamento 30 Aprile 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 000 000,00

Contributo UE

€ 2 000 000,00

Coordinato da

WEIZMANN INSTITUTE OF SCIENCE
Israel

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (18)

Space-time logic of liver gene expression at sub-lobular scale

Autori: Colas Droin, Jakob El Kholtei, Keren Bahar Halpern, Clémence Hurni, Milena Rozenberg, Sapir Muvkadi, Shalev Itzkovitz, Felix Naef
Pubblicato in: Nature Metabolism, Numero 3/1, 2021, Pagina/e 43-58, ISSN 2522-5812
Editore: Nature Metabolism
DOI: 10.1038/s42255-020-00323-1

Clump sequencing exposes the spatial expression programs of intestinal secretory cells

Autori: Rita Manco The Weizmann Institute of Science, Department of Molecular Cell Biology Inna Averbukh The Weizmann Institute of Science, Department of Molecular Cell Biology Ziv Porat The Weizmann Institute of Science, Life Sciences Core Facilities Keren Bahar Halpern The Weizmann Institute of Science, Department of Molecular Cell Biology Ido Amit The Weizmann Institute of Science, Department of Sy
Pubblicato in: Nature communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-23245-2

Distal fecal wash host transcriptomics identifies inflammation throughout the colon and terminal ileum

Autori: Stav Dan The Weizmann Institute of Science, Department of Molecular Cell Biology Bella Ungar Tel Aviv University Shani Ben-Moshe The Weizmann Institute of Science, Department of Molecular Cell Biology Keren Bahar Halpern The Weizmann Institute of Science, Department of Molecular Cell Biology Miri Yavzori Tel Aviv University Ella Fudim Tel Aviv University Orit Picard Tel Aviv University Chay
Pubblicato in: Cellular and molecular gastroenterology and hepatology, 2023, ISSN 2352-345X
Editore: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2023.02.002

Zonation of Pancreatic Acinar Cells in Diabetic Mice

Autori: Adi Egozi, Keren Bahar Halpern, Lydia Farack, Hagar Rotem, Shalev Itzkovitz
Pubblicato in: Cell Reports, Numero 32/7, 2020, Pagina/e 108043, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.108043

The spatiotemporal program of zonal liver regeneration following acute injury

Autori: Shani Ben-Moshe, Tamar Veg, Rita Manco, Stav Dan, Delfina Papinutti, Aviezer Lifshitz, Aleksandra A Kolodziejczyk, Keren Bahar Halpern, Eran Elinav and Shalev Itzkovitz
Pubblicato in: Cell stem cell, 2022, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2022.04.008

Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas

Autori: Lydia Farack, Matan Golan, Adi Egozi, Nili Dezorella, Keren Bahar Halpern, Shani Ben-Moshe, Immacolata Garzilli, Beata Toth, Lior Roitman, Valery Krizhanovsky, Shalev Itzkovitz
Pubblicato in: Developmental Cell, 2019, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2018.11.001

Spatial discordances between mRNAs and proteins in the intestinal epithelium

Autori: Yotam Harnik, Lisa Buchauer, Shani Ben-Moshe, Inna Averbukh, Yishai Levin, Alon Savidor, Raya Eilam, Andreas E Moor and Shalev Itzkovitz
Pubblicato in: Nature metabolism, 2021, ISSN 2522-5812
Editore: Nature Research
DOI: 10.1038/s42255-021-00504-6

The cellular states and fates of shed intestinal cells

Autori: Keren Bahar Halpern*, Yael Korem Kohanim, Adi Biram, Yotam Harnik, Adi Egozi, Oran Yakubovsky, Ziv Shulman, Shalev Itzkovitz*
Pubblicato in: Nature metabolism, 2023, ISSN 2522-5812
Editore: Nature Research
DOI: 10.1038/s42255-023-00905-9

Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells

Autori: Keren Bahar Halpern, Rom Shenhav, Hassan Massalha, Beata Toth, Adi Egozi, Efi E. Massasa, Chiara Medgalia, Eyal David, Amir Giladi, Andreas E. Moor, Ziv Porat, Ido Amit, Shalev Itzkovitz*
Pubblicato in: Nature Biotechnology, Numero 36, 2018, Pagina/e 962-970, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/nbt.4231

Spatial sorting enables comprehensive characterization of liver zonation

Autori: Shani Ben-Moshe, Yonatan Shapira, Andreas E. Moor, Rita Manco, Tamar Veg, Keren Bahar Halpern, Shalev Itzkovitz
Pubblicato in: Nature Metabolism, Numero 1/9, 2019, Pagina/e 899-911, ISSN 2522-5812
Editore: Nature Metabolism
DOI: 10.1038/s42255-019-0109-9

Lgr5+telocytes are a signaling source at the intestinal villus tip

Autori: Keren Bahar Halpern, Hassan Massalha, Rachel K. Zwick, Andreas E. Moor, David Castillo-Azofeifa, Milena Rozenberg, Lydia Farack, Adi Egozi, Dan R. Miller, Inna Averbukh, Yotam Harnik, Noa Weinberg-Corem, Frederic J. de Sauvage, Ido Amit, Ophir D. Klein, Michal Shoshkes-Carmel, Shalev Itzkovitz
Pubblicato in: Nature Communications, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-15714-x

Spatial heterogeneity in the mammalian liver

Autori: Shani Ben-Moshe, Shalev Itzkovitz*
Pubblicato in: Nature Reviews Gastroenterology and Hepatology, 2019, ISSN 1759-5045
Editore: Nature Publishing Group
DOI: 10.1038/s41575-019-0134-x

Insulin is expressed by enteroendocrine cells during human fetal development

Autori: Adi Egozi, Dhana Llivichuzhca-Loja, Blake T McCourt, Keren Bahar Halpern, Lydia Farack, Xiaojing An, Fujing Wang, Kong Chen, Liza Konnikova and Shalev Itzkovitz
Pubblicato in: Nature medicine, 2021, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-021-01586-1

Spatial gene expression maps of the intestinal lymphoid follicle and associated epithelium identify zonated expression programs.

Autori: Noam Cohen; Noam Cohen; Hassan Massalha; Hassan Massalha; Shani Ben-Moshe; Adi Egozi; Milena Rozenberg; Keren Bahar Halpern; Shalev Itzkovitz
Pubblicato in: PLoS Biology, Vol 19, Iss 10, p e3001214 (2021), Numero 2, 2021, ISSN 1544-9173
Editore: Public Library of Science
DOI: 10.1371/journal.pbio.3001214

Protocol for Single-Molecule Fluorescence In Situ Hybridization for Intact Pancreatic Tissue

Autori: Lydia Farack - The Weizmann Institute of Science, Department of Molecular Cell Biology Shalev Itzkovitz - The Weizmann Institute of Science, Department of Molecular Cell Biology
Pubblicato in: STAR protocols, 2020, ISSN 2666-1667
Editore: Elsevier
DOI: 10.1016/j.xpro.2019.100007

Host transcriptome signatures in human faecal-washes predict histological remission in patients with IBD

Autori: Bella Ungar, Miri Yavzori, Ella Fudim, Orit Picard, Uri Kopylov, Rami Eliakim, Dror Shouval, Yishai Levin, Alon Savidor, Shani Ben-Moshe, Rita Manco, Stav Dan, Adi Egozi, Keren Bahar Halpern, Chen Mayer, Iris Barshack, Shomron Ben-Horin, Shalev Itzkovitz
Pubblicato in: Gut, 2022, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2021-325516

A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage

Autori: Amichay Afriat, Vanessa Zuzarte-Luis, Keren Bahar Halpern, Lisa Buchauer, Sofia Marques, Angelo Ferreira Chora, Aparajita Lahree, Ido Amit, Maria M. Mota*, Shalev Itzkovitz*
Pubblicato in: Nature (London), Numero 611, 2022, Pagina/e 563-569, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-05406-5

A single cell atlas of the human liver tumor microenvironment

Autori: Hassan Massalha, Keren Bahar Halpern, Samir Abu‐Gazala, Tamar Jana, Efi E Massasa, Andreas E Moor, Lisa Buchauer, Milena Rozenberg, Eli Pikarsky, Ido Amit, Gideon Zamir, Shalev Itzkovitz
Pubblicato in: Molecular Systems Biology, Numero 16/12, 2020, ISSN 1744-4292
Editore: Nature Publishing Group
DOI: 10.15252/msb.20209682