Molecular and functional evolution of human CD8+ T cell repertoires

Informazioni relative al progetto

TC-Evo

ID dell’accordo di sovvenzione: 792532

DOI

10.3030/792532

Progetto chiuso

Data della firma CE 23 Aprile 2018

Data di avvio 1 Maggio 2018

Data di completamento 13 Luglio 2021

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 249 179,40

Contributo UE

€ 249 179,40

Coordinato da

Stichting Sanquin Bloedvoorziening
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (16)

Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19

Autori: Shidan Tosif, Melanie R. Neeland, Philip Sutton, Paul V. Licciardi, Sohinee Sarkar, Kevin J. Selva, Lien Anh Ha Do, Celeste Donato, Zheng Quan Toh, Rachel Higgins, Carolien Van de Sandt, Melissa M. Lemke, Christina Y. Lee, Suzanne K. Shoffner, Katie L. Flanagan, Kelly B. Arnold, Francesca L. Mordant, Kim Mulholland, Julie Bines, Kate Dohle, Daniel G. Pellicci, Nigel Curtis, Sarah McNab, Andrew Ste
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-19545-8

Suboptimal SARS-CoV-2−specific CD8 + T cell response associated with the prominent HLA-A*02:01 phenotype

Autori: Jennifer R. Habel, Thi H. O. Nguyen, Carolien E. van de Sandt, Jennifer A. Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L. Flanagan, Denise L. Doolan, Joseph Torresi, Weisan Chen, Linda M. Wakim, Allen C. Cheng, Peter C. Doherty, Jan Petersen, Jamie Rossjohn, Adam K. Wheatley, Stephen J. Kent, Louise C. Rowntre
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 117/39, 2020, Pagina/e 24384-24391, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2015486117

Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients

Autori: Thi H. O. Nguyen, Marios Koutsakos, Carolien E. van de Sandt, Jeremy Chase Crawford, Liyen Loh, Sneha Sant, Ludivine Grzelak, Emma K. Allen, Tim Brahm, E. Bridie Clemens, Maria Auladell, Luca Hensen, Zhongfang Wang, Simone Nüssing, Xiaoxiao Jia, Patrick Günther, Adam K. Wheatley, Stephen J. Kent, Malet Aban, Yi-Mo Deng, Karen L. Laurie, Aeron C. Hurt, Stephanie Gras, Jamie Rossjohn, Jane Crowe,
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-23018-x

Robust correlations across six SARS‐CoV‐2 serology assays detecting distinct antibody features

Autori: Louise C Rowntree, Brendon Y Chua, Suellen Nicholson, Marios Koutsakos, Luca Hensen, Celia Douros, Kevin Selva, Francesca L Mordant, Chinn Yi Wong, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lily Allen, Denise L Doolan, David C Jackson, Adam K Wheatley, Stephen J Kent, Fatima Amanat, Florian Krammer, Kanta Subbarao, Allen C Cheng, Amy W Chung, Mike Catton, Thi HO Nguyen, Carolien E Sandt, Katheri
Pubblicato in: Clinical & Translational Immunology, Numero 10/3, 2021, Pagina/e 1-18, ISSN 2050-0068
Editore: Australian and New Zealand Society for Immunology
DOI: 10.1002/cti2.1258

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells

Autori: Sneha Sant, Sergio M. Quiñones-Parra, Marios Koutsakos, Emma J. Grant, Thomas Loudovaris, Stuart I. Mannering, Jane Crowe, Carolien E. van de Sandt, Guus F. Rimmelzwaan, Jamie Rossjohn, Stephanie Gras, Liyen Loh, Thi H. O. Nguyen, Katherine Kedzierska
Pubblicato in: PLOS Pathogens, Numero 16/8, 2020, Pagina/e e1008714, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1008714

Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians

Autori: Luca Hensen, Thi H. O. Nguyen, Louise C. Rowntree, Timon Damelang, Marios Koutsakos, Malet Aban, Aeron Hurt, Kim L. Harland, Maria Auladell, Carolien E. van de Sandt, Anngie Everitt, Cath Blacker, Damian A. Oyong, Jessica R. Loughland, Jessica R. Webb, Bruce D. Wines, P. Mark Hogarth, Katie L. Flanagan, Magdalena Plebanski, Adam Wheatley, Amy W. Chung, Stephen J. Kent, Adrian Miller, E. Bridie Cle
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 118/41, 2021, Pagina/e e2109388118, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2109388118

Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine

Autori: E. Clemens, Carolien van de Sandt, Sook Wong, Linda Wakim, Sophie Valkenburg
Pubblicato in: Vaccines, Numero 6/2, 2018, Pagina/e 18, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines6020018

Back to the Future: Lessons Learned From the 1918 Influenza Pandemic

Autori: Kirsty R. Short, Katherine Kedzierska, Carolien E. van de Sandt
Pubblicato in: Frontiers in Cellular and Infection Microbiology, Numero 8, 2018, ISSN 2235-2988
Editore: Frontiers Media S. A.
DOI: 10.3389/fcimb.2018.00343

Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19

Autori: Irani Thevarajan, Thi H. O. Nguyen, Marios Koutsakos, Julian Druce, Leon Caly, Carolien E. van de Sandt, Xiaoxiao Jia, Suellen Nicholson, Mike Catton, Benjamin Cowie, Steven Y. C. Tong, Sharon R. Lewin, Katherine Kedzierska
Pubblicato in: Nature Medicine, 2020, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-020-0819-2

Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph

Autori: C. E. van de Sandt, E. B. Clemens, E. J. Grant, L. C. Rowntree, S. Sant, H. Halim, J. Crowe, A. C. Cheng, T. C. Kotsimbos, M. Richards, A. Miller, S. Y. C. Tong, J. Rossjohn, T. H. O. Nguyen, S. Gras, W. Chen, K. Kedzierska
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-13346-4

Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality

Autori: Kylie M. Quinn, Tabinda Hussain, Felix Kraus, Luke E. Formosa, Wai K. Lam, Michael J. Dagley, Eleanor C. Saunders, Lisa M. Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E. van de Sandt, Lucy Cooper, Kim L. Good-Jacobson, Katherine Kedzierska, Laura K. Mackay, Malcolm J. McConville, Georg Ramm, Michael T. Ryan, Nicole L. La Gruta
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-16633-7

CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

Autori: Luca Hensen, Patricia T. Illing, E. Bridie Clemens, Thi H. O. Nguyen, Marios Koutsakos, Carolien E. van de Sandt, Nicole A. Mifsud, Andrea T. Nguyen, Christopher Szeto, Brendon Y. Chua, Hanim Halim, Simone Rizzetto, Fabio Luciani, Liyen Loh, Emma J. Grant, Phillipa M. Saunders, Andrew G. Brooks, Steve Rockman, Tom C. Kotsimbos, Allen C. Cheng, Michael Richards, Glen P. Westall, Linda M. Wakim, Tho
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-23212-x

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Autori: Kevin J. Selva, Carolien E. van de Sandt, Melissa M. Lemke, Christina Y. Lee, Suzanne K. Shoffner, Brendon Y. Chua, Samantha K. Davis, Thi H. O. Nguyen, Louise C. Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C. Jackson, Katie L. Flanagan, Jane Crowe, Shidan Tosif, Melanie R. Neeland, Philip Sutton, Paul V. Licciardi, Nigel W. Crawford, Allen C. Cheng, Denise L.
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-22236-7

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

Autori: Marios Koutsakos, Louise C. Rowntree, Luca Hensen, Brendon Y. Chua, Carolien E. van de Sandt, Jennifer R. Habel, Wuji Zhang, Xiaoxiao Jia, Lukasz Kedzierski, Thomas M. Ashhurst, Givanna H. Putri, Felix Marsh-Wakefield, Mark N. Read, Davis N. Edwards, E Bridie Clemens, Chinn Yi Wong, Francesca L. Mordant, Jennifer A. Juno, Fatima Amanat, Jennifer Audsley, Natasha E. Holmes, Claire L. Gordon, Olivia
Pubblicato in: Cell Reports Medicine, 2021, Pagina/e 100208, ISSN 2666-3791
Editore: Cell Press
DOI: 10.1016/j.xcrm.2021.100208

CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

Autori: Thi H.O. Nguyen, Louise C. Rowntree, Jan Petersen, Brendon Y. Chua, Luca Hensen, Lukasz Kedzierski, Carolien E. van de Sandt, Priyanka Chaurasia, Hyon-Xhi Tan, Jennifer R. Habel, Wuji Zhang, Lilith F. Allen, Linda Earnest, Kai Yan Mak, Jennifer A. Juno, Kathleen Wragg, Francesca L. Mordant, Fatima Amanat, Florian Krammer, Nicole A. Mifsud, Denise L. Doolan, Katie L. Flanagan, Sabrina Sonda, Jasvee
Pubblicato in: Immunity, 2021, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2021.04.009

Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCRαβ Clonotypes with Potent Antimicrobial Responses

Autori: Liyen Loh, Nicholas A. Gherardin, Sneha Sant, Ludivine Grzelak, Jeremy Chase Crawford, Nicola L. Bird, Hui-Fern Koay, Carolien E. van de Sandt, Marcela L. Moreira, Martha Lappas, E. Kaitlynn Allen, Jane Crowe, Thomas Loudovaris, Katie L. Flanagan, Kylie M. Quinn, Jamie Rossjohn, Paul G. Thomas, Sidonia B. G. Eckle, James McCluskey, Dale I. Godfrey, Katherine Kedzierska
Pubblicato in: The Journal of Immunology, Numero 204/5, 2020, Pagina/e 1119-1133, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1900774