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PREcision MEDicine with induced pluripotent stem cells for Cardiac Arrhythmias Risk Evaluation

Publications

Estimating the Posttest Probability of Long QT Syndrome Diagnosis for Rare KCNH2 Variants

Author(s): Krystian Kozek, Yuko Wada, Luca Sala, Isabelle Denjoy, Christian Egly, Matthew J. O’Neill, Takeshi Aiba, Wataru Shimizu, Naomasa Makita, Taisuke Ishikawa, Lia Crotti, Carla Spazzolini, Maria-Christina Kotta, Federica Dagradi, Silvia Castelletti, Matteo Pedrazzini, Massimiliano Gnecchi, Antoine Leenhardt, Joe-Elie Salem, Seiko Ohno, Yi Zuo, Andrew M. Glazer, Jonathan D. Mosley, Dan M. Roden, Bjor
Published in: Circulation: Genomic and Precision Medicine, Issue 14/4, 2021, ISSN 2574-8300
DOI: 10.1161/circgen.120.003289

MTMR4 SNVs modulate ion channel degradation and clinical severity in congenital long QT syndrome: insights in the mechanism of action of protective modifier genes

Author(s): Yee-Ki Lee, Luca Sala, Manuela Mura, Marcella Rocchetti, Matteo Pedrazzini, Xinru Ran, Timothy S H Mak, Lia Crotti, Pak C Sham, Eleonora Torre, Antonio Zaza, Peter J Schwartz, Hung-Fat Tse, Massimiliano Gnecchi
Published in: Cardiovascular Research, 2020, ISSN 0008-6363
DOI: 10.1093/cvr/cvaa019

Long QT Syndrome Modelling with Cardiomyocytes Derived from Human-induced Pluripotent Stem Cells

Author(s): Luca Sala, Massimiliano Gnecchi, Peter J Schwartz
Published in: Arrhythmia & Electrophysiology Review, Issue 8/2, 2019, Page(s) 105, ISSN 2050-3377
DOI: 10.15420/aer.2019.1.1

Precision Versus Traditional Medicine—Clinical Questions Trigger Progress in Basic Science

Author(s): Peter J. Schwartz, Luca Sala
Published in: Circulation Research, Issue 124/4, 2019, Page(s) 459-461, ISSN 0009-7330
DOI: 10.1161/circresaha.119.314629

Precision Medicine and cardiac channelopathies: when dreams meet reality

Author(s): Massimiliano Gnecchi, Luca Sala, Peter J Schwartz
Published in: European Heart Journal, Issue 42/17, 2021, Page(s) 1661-1675, ISSN 0195-668X
DOI: 10.1093/eurheartj/ehab007

Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias

Author(s): Karina O. Brandão, Lettine van den Brink, Duncan C. Miller, Catarina Grandela, Berend J. van Meer, Mervyn P.H. Mol, Tessa de Korte, Leon G.J. Tertoolen, Christine L. Mummery, Luca Sala, Arie O. Verkerk, Richard P. Davis
Published in: Stem Cell Reports, Issue 15/5, 2020, Page(s) 1127-1139, ISSN 2213-6711
DOI: 10.1016/j.stemcr.2020.10.005

Cardiac Repolarization and Stem Cells: An Emerging Path Toward Precision Medicine

Author(s): Massimiliano Gnecchi, Luca Sala, Peter J. Schwartz
Published in: Cardiac Repolarization - Basic Science and Clinical Management, 2020, Page(s) 87-107
DOI: 10.1007/978-3-030-22672-5_4