PREcision MEDicine with induced pluripotent stem cells for Cardiac Arrhythmias Risk Evaluation

Estimating the Posttest Probability of Long QT Syndrome Diagnosis for Rare KCNH2 Variants

Autorzy: Krystian Kozek, Yuko Wada, Luca Sala, Isabelle Denjoy, Christian Egly, Matthew J. O’Neill, Takeshi Aiba, Wataru Shimizu, Naomasa Makita, Taisuke Ishikawa, Lia Crotti, Carla Spazzolini, Maria-Christina Kotta, Federica Dagradi, Silvia Castelletti, Matteo Pedrazzini, Massimiliano Gnecchi, Antoine Leenhardt, Joe-Elie Salem, Seiko Ohno, Yi Zuo, Andrew M. Glazer, Jonathan D. Mosley, Dan M. Roden, Bjor
Opublikowane w: Circulation: Genomic and Precision Medicine, Numer 14/4, 2021, ISSN 2574-8300
Wydawca: Lippincott Williams & Wilkins
DOI: 10.1161/circgen.120.003289

MTMR4 SNVs modulate ion channel degradation and clinical severity in congenital long QT syndrome: insights in the mechanism of action of protective modifier genes

Autorzy: Yee-Ki Lee, Luca Sala, Manuela Mura, Marcella Rocchetti, Matteo Pedrazzini, Xinru Ran, Timothy S H Mak, Lia Crotti, Pak C Sham, Eleonora Torre, Antonio Zaza, Peter J Schwartz, Hung-Fat Tse, Massimiliano Gnecchi
Opublikowane w: Cardiovascular Research, 2020, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvaa019

Long QT Syndrome Modelling with Cardiomyocytes Derived from Human-induced Pluripotent Stem Cells

Autorzy: Luca Sala, Massimiliano Gnecchi, Peter J Schwartz
Opublikowane w: Arrhythmia & Electrophysiology Review, Numer 8/2, 2019, Strona(/y) 105, ISSN 2050-3377
Wydawca: Radcliffe Cardiology
DOI: 10.15420/aer.2019.1.1

Precision Versus Traditional Medicine—Clinical Questions Trigger Progress in Basic Science

Autorzy: Peter J. Schwartz, Luca Sala
Opublikowane w: Circulation Research, Numer 124/4, 2019, Strona(/y) 459-461, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.314629

Precision Medicine and cardiac channelopathies: when dreams meet reality

Autorzy: Massimiliano Gnecchi, Luca Sala, Peter J Schwartz
Opublikowane w: European Heart Journal, Numer 42/17, 2021, Strona(/y) 1661-1675, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehab007

Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias

Autorzy: Karina O. Brandão, Lettine van den Brink, Duncan C. Miller, Catarina Grandela, Berend J. van Meer, Mervyn P.H. Mol, Tessa de Korte, Leon G.J. Tertoolen, Christine L. Mummery, Luca Sala, Arie O. Verkerk, Richard P. Davis
Opublikowane w: Stem Cell Reports, Numer 15/5, 2020, Strona(/y) 1127-1139, ISSN 2213-6711
Wydawca: Cell Press
DOI: 10.1016/j.stemcr.2020.10.005

Cardiac Repolarization and Stem Cells: An Emerging Path Toward Precision Medicine

Autorzy: Massimiliano Gnecchi, Luca Sala, Peter J. Schwartz
Opublikowane w: Cardiac Repolarization - Basic Science and Clinical Management, 2020, Strona(/y) 87-107, ISBN 978-3-030-22671-8
Wydawca: Springer International Publishing
DOI: 10.1007/978-3-030-22672-5_4

Use of hiPSC-derived cardiomyocytes to rule out proarrhythmic effects of drugs: the case of hydroxychloroquine in COVID-19

Autorzy: Luca Sala, Vladislav Leonov, Manuela Mura, Alessandra Moretti, Lia Crotti, Massimiliano Gnecchi, Peter J Schwartz
Opublikowane w: biorXiv, 2021
Wydawca: biorXiv
DOI: 10.1101/2021.06.25.449913

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