3D bioprinting of pancreatic tissue for biomedical research

Informazioni relative al progetto

Pan3DP

ID dell’accordo di sovvenzione: 800981

DOI 10.3030/800981

Progetto chiuso

Data della firma CE 3 Maggio 2018

Data di avvio 1 Ottobre 2018

Data di completamento 30 Settembre 2022

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale € 3 000 000,00

Contributo UE € 3 000 000,00

Coordinato da

KING'S COLLEGE LONDON
United Kingdom

Risultati finali

Websites, patent fillings, videos etc. (6)

Public dissemination
Dissemination WP2

Dissemination for WP2

Consortium website
Dissemination WP1

Dissemination for WP1

Consortium workshops I
Consortium workshop II

Other (2)

3D image-based mechanistic model
Generation of a digital embryonic pancreas atlas

Documents, reports (3)

Dissemination WP3

Dissemination for WP3

Definition of each cell population in the pancreas
Deposing RNAseq datasets in public repositories

Demonstrators, pilots, prototypes (4)

Protocol of printability conditions of pancreatic cells
Protocol of biomaterials for printing pancreatic cells
Generation of CAD files for 3D bio-printing
Protocol of vasculature integration

Pubblicazioni

Non-peer reviewed articles (4)

Development of a 3D atlas of the embryonic pancreas for topological and quantitative analysis of heterologous cell interactions

Autori: Laura Glorieux, Aleksandra Sapala, David Willnow, Manon Moulis, Shlomit Edri, Jean-Francois Darrigrand, Anat Schonblum, Lina Sakhneny, Laura Schaumann, Harold F Gomez, Christine Lang, Lisa Conrad, Fabien Guillemot, Shulamit Levenberg, Limor Landsman, Dagmar Iber, Christophe Pierreux, Francesca M Spagnoli
Pubblicato in: bioRxiv, 2021, ISSN 2692-8205
Editore: Cold Spring Harbour Laboratories
DOI: 10.1101/2021.04.28.441857

Quantitative lineage analysis identifies a long-term progenitor niche for the hepato-pancreato-biliary organ system

Autori: David Willnow, Uwe Benary, Anca Margineanu, Maria Lillina Vignola, Igor M. Pongrac, Zahra Karimaddini, Alessandra Vigilante, Jana Wolf,  Francesca M. Spagnoli
Pubblicato in: bioRxiv, 2020, ISSN 2692-8205
Editore: Cold Spring Harbour Laboratories
DOI: 10.1101/2020.08.06.240176

Single cell transcriptomic comparison between mouse embryonic pancreas and pancreatic organoids generated from mouse embryonic stem cell-derived mesoderm and pancreatic progenitors

Autori: Shlomit Edri, Vardit Rosenthal, Or Ginsburg, Abigail Newman Frisch, Christophe E. Pierreux, Nadav Sharon, Shulamit Levenberg
Pubblicato in: BioRxiv, Numero 26928205, 2022, ISSN 2692-8205
Editore: CSHL
DOI: 10.1101/2022.10.11.511696

Cell-based simulations of Notch-dependent cell differentiation on growing domains

Autori: Stopka Anna, Boareto do Amaral Marcelo, Iber Dagmar
Pubblicato in: bioRxiv, 2019, Pagina/e 859363, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/859363

Peer reviewed articles (8)

Beta cell dysfunction in diabetes: the islet microenvironment as an unusual suspect

Autori: Joana Almaça, Alejandro Caicedo, Limor Landsman
Pubblicato in: Diabetologia, Numero 63/10, 2020, Pagina/e 2076-2085, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05186-5

Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche

Autori: David Willnow, Uwe Benary , Anca Margineanu , Maria Lillina Vignola, Fabian Konrath, Igor M Pongrac, Zahra Karimaddini , Alessandra Vigilante, Jana Wolf, Francesca M Spagnoli
Pubblicato in: Nature, Numero 00280836, 2021, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03844-1

The Role of Vascular Cells in Pancreatic Beta-Cell Function

Autori: Guzel Burganova, Claire Bridges, Peter Thorn, Limor Landsman
Pubblicato in: Frontiers in Endocrinology, Numero 12, 2021, ISSN 1664-2392
Editore: Frontiers Media SA
DOI: 10.3389/fendo.2021.667170

Development of a 3D atlas of the embryonic pancreas for topological and quantitative analysis of heterologous cell interactions

Autori: Laura Glorieux; Aleksandra Sapala; David Willnow; Manon Moulis; Anna Salowka; Jean-Francois Darrigrand; Shlomit Edri; Anat Schonblum; Lina Sakhneny; Laura Schaumann; Harold F. Gómez; Christine Lang; Lisa Conrad; Fabien Guillemot; Shulamit Levenberg; Limor Landsman; Dagmar Iber; Christophe E. Pierreux; Francesca M. Spagnoli
Pubblicato in: Development, Numero 09501991, 2022, ISSN 0950-1991
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dev.199655

Pancreatic cell fate specification: insights into developmental mechanisms and their application for lineage reprogramming.

Autori: Abigail Isaacson; Francesca M. Spagnoli
Pubblicato in: Current Opinion in Genetics & Development, Numero 0959437X, 2021, ISSN 0959-437X
Editore: Elsevier BV
DOI: 10.1016/j.gde.2021.05.003

Pancreatic pericytes originate from the embryonic pancreatic mesenchyme

Autori: Neta Harari, Lina Sakhneny, Laura Khalifa-Malka, Anke Busch, Klemens J. Hertel, Matthias Hebrok, Limor Landsman
Pubblicato in: Developmental Biology, Numero 449/1, 2019, Pagina/e 14-20, ISSN 0012-1606
Editore: Academic Press
DOI: 10.1016/j.ydbio.2019.01.020

Identification and implication of tissue-enriched ligands in epithelial–endothelial crosstalk during pancreas development

Autori: Manon Moulis; Steve Vincent Maurice Runser; Laura Glorieux; Nicolas Dauguet; Christophe Vanderaa; Laurent Gatto; Donatienne Tyteca; Patrick Henriet; Francesca M. Spagnoli; Dagmar Iber; Christophe E. Pierreux
Pubblicato in: Scientific Reports, Numero 20452322, 2022, Pagina/e 12498, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-16072-y 

A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation

Autori: Corinna Cozzitorto, Laura Mueller, Silvia Ruzittu, Nancy Mah, David Willnow, Jean-Francois Darrigrand, Heather Wilson, Daniel Khosravinia, Amir-Ala Mahmoud, Maurizio Risolino, Licia Selleri, Francesca M. Spagnoli
Pubblicato in: Developmental Cell, 2020, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2020.08.003