Deliverables Websites, patent fillings, videos etc. (1) MiCoBion webpage developed MiCoBion webpage developed Documents, reports (2) Organized Advanced course in metagenomics and OMICs data integration Organized Advanced course in metagenomics and OMICs data integration Dissemination and Communication strategy document prepared Dissemination and Communication strategy document prepared Publications Peer reviewed articles (31) Adaptive iron utilization compensates for the lack of an inducible uptake system in Naegleria fowleri and represents a potential target for therapeutic intervention Author(s): Arbon, D; Zeniskova, K; Mach, J; Grechnikova, M; Malych, R; Talacko, P; Sutak, R Published in: PLOS NEGLECTED TROPICAL DISEASES, 2020, ISSN 1935-2735 Publisher: Public Library of Science DOI: 10.1371/journal.pntd.0007759 Cytidine nucleoside analog is an effective antiviral drug against Trichomonasvirus Author(s): Narayanasamy, RK; Rada, P; Zdrha, A; van Ranst, M; Neyts, J; Tachezy, J Published in: JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, 2022, ISSN 1684-1182 Publisher: Elsevier Taiwan DOI: 10.1016/j.jmii.2021.08.008 Copper Metabolism in Naegleria gruberi and Its Deadly Relative Naegleria fowleri Author(s): Kateřina Ženíšková; Maria Grechnikova; Robert Sutak Published in: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, Issue 9, 2022, ISSN 2296-634X Publisher: Frontiers Media S.A. DOI: 10.3389/fcell.2022.853463 Late Pleistocene Expansion of Small Murid Rodents across the Palearctic in Relation to the Past Environmental Changes Author(s): Kozyra, K; Zajac, TM; Ansorge, H; Wierzbicki, H; Moska, M; Stanko, M; Stopka, P Published in: GENES, 2021, ISSN 2073-4425 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/genes12050642 Proteomic Analysis of Trichomonas vaginalis Phagolysosome, Lysosomal Targeting, and Unconventional Secretion of Cysteine Peptidases Author(s): Zimmann, N; Rada, P; Zarsky, V; Smutna, T; Zahonova, K; Dacks, J; Harant, K; Hrdy, I; Tachezy, J Published in: MOLECULAR & CELLULAR PROTEOMICS, 2022, ISSN 1535-9484 Publisher: American Society for Biochemistry and Molecular Biology DOI: 10.1016/j.mcpro.2021.100174 Copper detoxification machinery of the brain-eating amoeba Naegleria fowleri involves copper-translocating ATPase and the antioxidant system Author(s): Grechnikova, M; Zeniskova, K; Malych, R; Mach, J; Sutak, R Published in: INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE, 2020, ISSN 2211-3207 Publisher: Elsevier BV DOI: 10.1016/j.ijpddr.2020.10.001 The iron-sulfur scaffold protein HCF101 unveils the complexity of organellar evolution in SAR, Haptista and Cryptista Author(s): Pyrih, J; Zarsky, V; Fellows, JD; Grosche, C; Wloga, D; Striepen, B; Maier, UG; Tachezy, J Published in: BMC ECOLOGY AND EVOLUTION, 2021, ISSN 2730-7182 Publisher: BioMed Central DOI: 10.1186/s12862-021-01777-x Perspectives: SARS-CoV-2 Spike Convergent Evolution as a Guide to Explore Adaptive Advantage Author(s): Zahradnik, J; Nunvar, J; Schreiber, G Published in: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2022, ISSN 2235-2988 Publisher: Frontiers Media S. A. DOI: 10.3389/fcimb.2022.748948 The Virome of Healthy Honey Bee Colonies: Ubiquitous Occurrence of Known and New Viruses in Bee Populations Author(s): Kadleckova, D; Tachezy, R; Erban, T; Deboutte, W; Nunvar, J; Salakova, M; Matthijnssens, J Published in: MSYSTEMS, 2022, ISSN 2379-5077 Publisher: American Society for Microbiology DOI: 10.1128/msystems.00072-22 Iron in parasitic protists - from uptake to storage and where we can interfere. Author(s): Jan Mach; Robert Sutak Published in: METALLOMICS, Issue 8, 2020, ISSN 1756-5901 Publisher: Royal Society of Chemistry DOI: 10.1039/d0mt00125b Flow cytometry-based study of model marine microalgal consortia revealed an ecological advantage of siderophore utilization by the dinoflagellate Amphidinium carterae Author(s): Malych, R; Stopka, P; Mach, J; Kotabova, E; Prasil, O; Sutak, R Published in: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2022, ISSN 2001-0370 Publisher: Elsevier DOI: 10.1016/j.csbj.2021.12.023 Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism Author(s): Václav Hönig; Jan Kamiš; Aneta Maršíková; Tereza Matějková; Pavel Stopka; Anna Mácová; Daniel Růžek; Jana Kvičerová Published in: MICROBIOLOGY SPECTRUM, Issue 8, 2022, ISSN 2165-0497 Publisher: American Society for Microbiology DOI: 10.1128/spectrum.01306-22 Do all mice smell the same? Chemosensory cues from inbred and wild mouse strains elicit stereotypic sensory representations in the accessory olfactory bulb. Author(s): Rohini Bansal; Maximilian Nagel; Romana Stopková; Yizhak Sofer; Tali Kimchi; Pavel Stopka; Marc Spehr; Yoram Ben-Shaul Published in: BMC biology 19(1), 133 (2021). doi:10.1186/s12915-021-01064-7, Issue 3, 2021, ISSN 1741-7007 Publisher: BioMed Central DOI: 10.18154/rwth-2021-07103 The Mastigamoeba balamuthi genome and the nature of the free-living ancestor of Entamoeba Author(s): Žárský V., Klimeš V., Pačes J., Vlček Č, Hradilová M., Beneš V., Nývltová E., Hrdý I., Pyrih J, Mach J., Barlow L., Stairs C.W., Eme L., Hall N., Eliáš M., Dacks BJ, Roger A., Tachezy J. Published in: Mol Biol Evol. 2021 Jun; 38(6): 2240–2259, 2021, ISSN 1537-1719 Publisher: Oxford University Press, Society for Molecular Biology and Evolution DOI: 10.1093/molbev/msab020 Oral and vaginal microbiota in selected field mice of the genus Apodemus: a wild population study Author(s): Matejkova, T; Hajkova, P; Stopkova, R; Stanko, M; Martin, JF; Kreisinger, J; Stopka, P Published in: SCIENTIFIC REPORTS, 2020, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-020-70249-x The response of Naegleria gruberi to oxidative stress Author(s): Malych, Ronald; Fussy, Zoltan; Zeniskova, Katerina; Arbon, Dominik; Hampl, Vladimir; Hrdy, Ivan; Sutak, Robert Published in: METALLOMICS, 2022, ISSN 1756-5901 Publisher: Royal Society of Chemistry DOI: 10.1093/mtomcs/mfac009 Phenotypic and Clonal Stability of Antigen-Inexperienced Memory-like T Cells across the Genetic Background, Hygienic Status, and Aging Author(s): Moudra, A; Niederlova, V; Novotny, J; Schmiedova, L; Kubovciak, J; Matejkova, T; Drobek, A; Pribikova, M; Stopkova, R; Cizkova, D; Neuwirth, A; Michalik, J; Krizova, K; Hudcovic, T; Kolar, M; Kozakova, H; Kreisinger, J; Stopka, P; Stepanek, O Published in: JOURNAL OF IMMUNOLOGY, 2021, ISSN 0022-1767 Publisher: American Association of Immunologists DOI: 10.4049/jimmunol.2001028 Giardia intestinalis mitosomes undergo synchronized fission but not fusion and are constitutively associated with the endoplasmic reticulum Author(s): Luboš Voleman, Vladimíra Najdrová, Ásgeir Ástvaldsson, Pavla Tůmová, Elin Einarsson, Zdeněk Švindrych, Guy M. Hagen, Jan Tachezy, Staffan G. Svärd, Pavel Doležal Published in: BMC Biology, Issue 15/1, 2017, ISSN 1741-7007 Publisher: BioMed Central DOI: 10.1186/s12915-017-0361-y High-Throughput Analysis of Human Cytomegalovirus Genome Diversity Highlights the Widespread Occurrence of Gene-Disrupting Mutations and Pervasive Recombination Author(s): Steven Sijmons, Kim Thys, Mirabeau Mbong Ngwese, Ellen Van Damme, Jan Dvorak, Marnix Van Loock, Guangdi Li, Ruth Tachezy, Laurent Busson, Jeroen Aerssens, Marc Van Ranst, Piet Maes Published in: Journal of Virology, Issue 89/15, 2015, Page(s) 7673-7695, ISSN 0022-538X Publisher: American Society for Microbiology DOI: 10.1128/JVI.00578-15 A Novel Protein, Ubiquitous in Marine Phytoplankton, Concentrates Iron at the Cell Surface and Facilitates Uptake Author(s): Joe Morrissey, Robert Sutak, Javier Paz-Yepes, Atsuko Tanaka, Ahmed Moustafa, Alaguraj Veluchamy, Yann Thomas, Hugo Botebol, François-Yves Bouget, Jeffrey B. McQuaid, Leila Tirichine, Andrew E. Allen, Emmanuel Lesuisse, Chris Bowler Published in: Current Biology, Issue 25/3, 2015, Page(s) 364-371, ISSN 0960-9822 Publisher: Cell Press DOI: 10.1016/j.cub.2014.12.004 A Eukaryote without a Mitochondrial Organelle Author(s): Anna Karnkowska, Vojtěch Vacek, Zuzana Zubáčová, Sebastian C. Treitli, Romana Petrželková, Laura Eme, Lukáš Novák, Vojtěch Žárský, Lael D. Barlow, Emily K. Herman, Petr Soukal, Miluše Hroudová, Pavel Doležal, Courtney W. Stairs, Andrew J. Roger, Marek Eliáš, Joel B. Dacks, Čestmír Vlček, Vladimír Hampl Published in: Current Biology, Issue 26/10, 2016, Page(s) 1274-1284, ISSN 0960-9822 Publisher: Cell Press DOI: 10.1016/j.cub.2016.03.053 Understanding the potential of hepatitis C virus internal ribosome entry site domains to modulate translation initiation via their structure and function Author(s): Anas Khawaja, Vaclav Vopalensky, Martin Pospisek Published in: Wiley Interdisciplinary Reviews: RNA, Issue 6/2, 2015, Page(s) 211-224, ISSN 1757-7004 Publisher: John Wiley and Sons Inc. DOI: 10.1002/wrna.1268 Lateral Gene Transfer and Gene Duplication Played a Key Role in the Evolution of Mastigamoeba balamuthi Hydrogenosomes Author(s): Eva Nývltová, Courtney W. Stairs, Ivan Hrdý, Jakub Rídl, Jan Mach, Jan Pačes, Andrew J. Roger, Jan Tachezy Published in: Molecular Biology and Evolution, Issue 32/4, 2015, Page(s) 1039-1055, ISSN 0737-4038 Publisher: Oxford University Press DOI: 10.1093/molbev/msu408 Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells Author(s): Lan-Feng Dong, Jaromira Kovarova, Martina Bajzikova, Ayenachew Bezawork-Geleta, David Svec, Berwini Endaya, Karishma Sachaphibulkij, Ana R Coelho, Natasa Sebkova, Anna Ruzickova, An S Tan, Katarina Kluckova, Kristyna Judasova, Katerina Zamecnikova, Zuzana Rychtarcikova, Vinod Gopalan, Ladislav Andera, Margarita Sobol, Bing Yan, Bijay Pattnaik, Naveen Bhatraju, Jaroslav Truksa, Pavel Stopka, Pavel Published in: eLife, Issue 6, 2017, ISSN 2050-084X Publisher: eLife Sciences Publications DOI: 10.7554/eLife.22187 Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis Author(s): Junie Hovsepian, Quentin Defenouillère, Véronique Albanèse, Libuše Váchová, Camille Garcia, Zdena Palková, Sébastien Léon Published in: The Journal of Cell Biology, Issue 216/6, 2017, Page(s) 1811-1831, ISSN 0021-9525 Publisher: Rockefeller University Press DOI: 10.1083/jcb.201610094 Yeast cell differentiation: Lessons from pathogenic and non-pathogenic yeasts Author(s): Zdena Palková, Libuše Váchová Published in: Seminars in Cell & Developmental Biology, Issue 57, 2016, Page(s) 110-119, ISSN 1084-9521 Publisher: Academic Press DOI: 10.1016/j.semcdb.2016.04.006 Cyc8p and Tup1p transcription regulators antagonistically regulate Flo11p expression and complexity of yeast colony biofilms Author(s): Phu Van Nguyen, Otakar Hlaváček, Jana Maršíková, Libuše Váchová, Zdena Palková Published in: PLOS Genetics, Issue 14/7, 2018, Page(s) e1007495, ISSN 1553-7404 Publisher: PLOS DOI: 10.1371/journal.pgen.1007495 Messenger RNAs of Yeast Virus-Like Elements Contain Non-templated 5′ Poly(A) Leaders, and Their Expression Is Independent of eIF4E and Pab1 Author(s): Václav Vopálenský, Michal Sýkora, Tomáš Mašek, Martin Pospíšek Published in: Frontiers in Microbiology, Issue 10, 2019, ISSN 1664-302X Publisher: Frontiers Media DOI: 10.3389/fmicb.2019.02366 Copper and iron metabolism in Ostreococcus tauri – the role of phytotransferrin, plastocyanin and a chloroplast copper-transporting ATPase Author(s): Ivo Florin Scheiber, Jana Pilátová, Ronald Malych, Eva Kotabova, Matyáš Krijt, Daniel Vyoral, Jan Mach, Thibaut Léger, Jean-Michel Camadro, Ondřej Prášil, Emmanuel Lesuisse, Robert Sutak Published in: Metallomics, Issue 11/10, 2019, Page(s) 1657-1666, ISSN 1756-5901 Publisher: Royal Society of Chemistry DOI: 10.1039/c9mt00078j Anaerobic peroxisomes in Mastigamoeba balamuthi Author(s): Tien Le, Vojtěch Žárský, Eva Nývltová, Petr Rada, Karel Harant, Marie Vancová, Zdeněk Verner, Ivan Hrdý, Jan Tachezy Published in: Proceedings of the National Academy of Sciences, 2019, Page(s) 201909755, ISSN 0027-8424 Publisher: National Academy of Sciences DOI: 10.1073/pnas.1909755117 Anaerobic peroxisomes in Entamoeba histolytica metabolize myo-inositol Author(s): Verner, Z; Zarsky, V; Le, T; Narayanasamy, RK; Rada, P; Rozbesky, D; Makki, A; Belisova, D; Hrdy, I; Vancova, M; Lender, C; Konig, C; Bruchhaus, I; Tachezy, J Published in: PLOS PATHOGENS, 2021, ISSN 1553-7366 Publisher: Public Library of Science DOI: 10.1371/journal.ppat.1010041 Searching for OpenAIRE data... 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