Overcoming specific weaknesses in tendon biology to design advanced regenerative therapies

Hyaluronic acid as macromolecular crowder in equine adipose-derived stem cell cultures

Autori: Garnica-Galvez, S., Korntner, S. H., Skoufos, I., Tzora, A., Diakakis, N., Prassinos, N., & Zeugolis, D. I.
Pubblicato in: Cells, 2021, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10040859

Spectrum of Tendon Pathologies: Triggers, Trails and End-State

Autori: Sara Steinmann; Christian Pfeifer; Christoph Brochhausen; Denitsa Docheva
Pubblicato in: International Journal of Molecular Sciences, Numero 1, 2020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.5283/epub.41519

Magnetic triggers in biomedical applications - prospects for contact free cell sensing and guidance.

Autori: Ana Filipa Martins Almeida; Adriana Vinhas; Ana I. Gonçalves; Margarida S. Miranda; Márcia T. Rodrigues; Manuela E. Gomes
Pubblicato in: Journal of Materials Chemistry B, Numero 1, 2021, ISSN 2050-7518
Editore: Royal Society of Chemistry
DOI: 10.1039/d0tb02474k

Loss of tenomodulin expression is a risk factor for age‐related intervertebral disc degeneration

Autori: Dasheng Lin; Dasheng Lin; Paolo Alberton; Manuel Delgado Caceres; Carina Prein; Hauke Clausen-Schaumann; Jian Dong; Attila Aszodi; Chisa Shukunami; James C. Iatridis; Denitsa Docheva
Pubblicato in: Aging Cell, Numero 1, 2020, ISSN 1474-9726
Editore: John Wiley & Sons
DOI: 10.5283/epub.43124

Controlling the fate of regenerative cells with engineered platelet-derived extracellular vesicles

Autori: Graça, A. L., Gómez-Florit, M., Osório, H., Rodrigues, M. T., Domingues, R. M., Reis, R. L., & Gomes
Pubblicato in: Nanoscale, 2022, ISSN 2040-3372
Editore: Royal Society of Chemistry
DOI: 10.1039/d1nr08108j

Single Cell Bioprinting with Ultrashort Laser Pulses

Autori: Jun Zhang; Patrick Byers; Amelie Erben; Amelie Erben; Amelie Erben; Christine Frank; Levin Schulte-Spechtel; Michael Heymann; Michael Heymann; Denitsa Docheva; Heinz P. Huber; Stefanie Sudhop; Stefanie Sudhop; Hauke Clausen-Schaumann; Hauke Clausen-Schaumann
Pubblicato in: Advanced Functional Materials, Numero 1, 2021, ISSN 1616-3028
Editore: John Wiley & Sons
DOI: 10.5283/epub.52322

Changes of material elastic properties during healing of ruptured achilles tendons measured with shear wave elastography: A pilot study

Autori: Frankewycz, B., Henssler, L., Weber, J., Platz Batista da Silva, N., Koch, M., Jung, E. M., ... & Pfeifer, C. G.
Pubblicato in: International journal of molecular sciences, 2020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21103427

Modulation of stem cell response using biodegradable polyester films with different stiffness

Autori: Sofia Ribeiro; Eugenia Pugliese; Stefanie Korntner; Emanuel M. Fernandes; Manuela E. Gomes; Rui L. Reis; Yves Bayon; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Pubblicato in: Biomedical Engineering Advances, Numero 1, 2021, ISSN 2667-0992
Editore: Elsevier
DOI: 10.1016/j.bea.2021.100007

Growth factor and macromolecular crowding supplementation in human tenocyte culture

Autori: Tsiapalis, D., Kearns, S., Kelly, J. L., & Zeugolis, D. I.
Pubblicato in: Biomaterials and Biosystems, 2020, ISSN 2666-5344
Editore: Elsevier
DOI: 10.1016/j.bbiosy.2021.100009

Development and characterisation of cytocompatible polyester substrates with tunable mechanical properties and degradation rate

Autori: Ribeiro, S., Carvalho, A.M., Fernandes, E.M., Gomes, M.E., Reis, R.L., Bayon, Y. and D.I. Zeugolis
Pubblicato in: Acta Biomaterialia, 2021, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2020.11.026

Magnetic responsive materials modulate the inflammatory profile of IL-1β conditioned tendon cells.

Autori: Adriana Vinhas; Márcia T. Rodrigues; Ana I. Gonçalves; Rui L. Reis; Manuela E. Gomes
Pubblicato in: Acta Biomaterialia, Numero 1, 2020, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2020.09.028

Aged tendon stem/progenitor cells are less competent to form 3D tendon organoids due to cell autonomous and matrix production deficits

Autori: Yan, Z., Yin, H., Brochhausen, C., Pfeifer, C. G., Alt, V., & Docheva, D
Pubblicato in: Frontiers in Bioengineering and Biotechnology, 2020, ISSN 2296-4185
Editore: Frontiers Media
DOI: 10.3389/fbioe.2020.00406

Bioengineered 3D Living Fibers as In Vitro Human Tissue Models of Tendon Physiology and Pathology

Autori: Calejo I, Labrador-Rached CJ, Gomez-Florit M, Docheva D, Reis RL, Domingues RMA, Gomes ME
Pubblicato in: Adv Healthc Mater, 2022, ISSN 2192-2659
Editore: World Scientific
DOI: 10.1002/adhm.202102863

Allogeneic serum and macromolecular crowding maintain native equine tenocyte function in culture

Autori: Rampin, A., Skoufos, I., Raghunath, M., Tzora, A., Diakakis, N., Prassinos, N., & Zeugolis, D. I
Pubblicato in: Cells, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11091562

Magnetic Nanocomposite Hydrogels for Tissue Engineering: Design Concepts and Remote Actuation Strategies to Control Cell Fate

Autori: Alberto Pardo; Manuel Gómez-Florit; Silvia Barbosa; Pablo Taboada; Rui M. A. Domingues; Manuela E. Gomes
Pubblicato in: ACS nano, Numero 1, 2021, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.0c08253

The impact of cryopreservation in signature markers and immunomodulatory profile of tendon and ligament derived cells

Autori: Ana I. Gonçalves; Adriana Vinhas; Márcia T. Rodrigues; Manuela E. Gomes
Pubblicato in: Journal of Cellular Physiology, Numero 1, 2022, ISSN 1097-4652
Editore: John Wiley & Sons
DOI: 10.1002/jcp.30540

Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon

Autori: Delgado Caceres, M., Angerpointner, K., Galler, M., Lin, D., Michel, P. A., Brochhausen, C., ... & Docheva, D
Pubblicato in: Cell Death & Disease, 2021, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-021-04298-z

Epitope‐imprinted nanoparticles as transforming growth factor‐β3 sequestering ligands to modulate stem cell fate

Autori: Simão P. B. Teixeira; Rui M. A. Domingues; Pedro S. Babo; Dominika Berdecka; Margarida S. Miranda; Manuela E. Gomes; Nicholas A. Peppas; Rui L. Reis
Pubblicato in: Advanced Functional Materials, Numero 1, 2021, ISSN 1616-3028
Editore: John Wiley & Sons
DOI: 10.1002/adfm.202003934

Extending Single Cell Bioprinting from Femtosecond to Picosecond Laser Pulse Durations

Autori: Zhang, J., Geiger, Y., Sotier, F., Djordjevic, S., Docheva, D., Sudhop, S., ... & Huber, H. P.
Pubblicato in: Micromachines, 2021, ISSN 2072-666X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi12101172

Triggering the activation of Activin A type II receptor in human adipose stem cells towards tenogenic commitment using mechanomagnetic stimulation

Autori: A.I. Gonçalves, M. Rotherham, H. Markides, M.T. Rodrigues, R.L. Reis, M.E. Gomes, A.J. El Haj
Pubblicato in: Nanomedicine: Nanotechnology, Biology and Medicine, Numero 14/4, 2018, Pagina/e 1149-1159, ISSN 1549-9634
Editore: Elsevier BV
DOI: 10.1016/j.nano.2018.02.008

The effects of platelet lysate patches on the activity of tendon-derived cells

Autori: Raquel Costa-Almeida, Albina R. Franco, Tamagno Pesqueira, Mariana B. Oliveira, Pedro S. Babo, Isabel B. Leonor, João F. Mano, Rui L. Reis, Manuela E. Gomes
Pubblicato in: Acta Biomaterialia, Numero 68, 2018, Pagina/e 29-40, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2018.01.006

Cell-laden composite suture threads for repairing damaged tendons

Autori: Raquel Costa-Almeida, Rui M.A. Domingues, Afsoon Fallahi, Huseyin Avci, Iman K. Yazdi, Mohsen Akbari, Rui L. Reis, Ali Tamayol, Manuela E. Gomes, Ali Khademhosseini
Pubblicato in: Journal of Tissue Engineering and Regenerative Medicine, Numero 12/4, 2018, Pagina/e 1039-1048, ISSN 1932-6254
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/term.2605

Tissue-engineered magnetic cell sheet patches for advanced strategies in tendon regeneration

Autori: Ana I. Gonçalves, Márcia T. Rodrigues, Manuela E. Gomes
Pubblicato in: Acta Biomaterialia, Numero 63, 2017, Pagina/e 110-122, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2017.09.014

Multifunctional magnetic-responsive hydrogels to engineer tendon-to-bone interface

Autori: Elsa D. Silva, Pedro S. Babo, Raquel Costa-Almeida, Rui M.A. Domingues, Bárbara B. Mendes, Elvira Paz, Paulo Freitas, Márcia T. Rodrigues, Pedro L. Granja, Manuela E. Gomes
Pubblicato in: Nanomedicine: Nanotechnology, Biology and Medicine, Numero 14/7, 2018, Pagina/e 2375-2385, ISSN 1549-9634
Editore: Elsevier BV
DOI: 10.1016/j.nano.2017.06.002

Human adipose tissue-derived tenomodulin positive subpopulation of stem cells: A promising source of tendon progenitor cells

Autori: A.I. Gonçalves, P.M. Gershovich, M.T. Rodrigues, R.L. Reis, M.E. Gomes
Pubblicato in: Journal of Tissue Engineering and Regenerative Medicine, Numero 12/3, 2018, Pagina/e 762-774, ISSN 1932-6254
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/term.2495

In vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing

Autori: Lívia Santos, Marta Silva, Ana I. Gonçalves, Tamagno Pesqueira, Márcia T. Rodrigues, Manuela E. Gomes
Pubblicato in: Nanomedicine, Numero 11/9, 2016, Pagina/e 1107-1122, ISSN 1743-5889
Editore: Future Medicine Ltd.
DOI: 10.2217/nnm-2015-0014

3D Mimicry of Native-Tissue-Fiber Architecture Guides Tendon-Derived Cells and Adipose Stem Cells into Artificial Tendon Constructs

Autori: Mariana Laranjeira, Rui M. A. Domingues, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes
Pubblicato in: Small, Numero 13/31, 2017, Pagina/e 1700689, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201700689

Exploring the Potential of Starch/Polycaprolactone Aligned Magnetic Responsive Scaffolds for Tendon Regeneration

Autori: Ana I. Gonçalves, Márcia T. Rodrigues, Pedro P. Carvalho, Manuel Bañobre-López, Elvira Paz, Paulo Freitas, Manuela E. Gomes
Pubblicato in: Advanced Healthcare Materials, Numero 5/2, 2016, Pagina/e 213-222, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201500623

Enhancing the Biomechanical Performance of Anisotropic Nanofibrous Scaffolds in Tendon Tissue Engineering: Reinforcement with Cellulose Nanocrystals

Autori: Rui M. A. Domingues, Silvia Chiera, Pavel Gershovich, Antonella Motta, Rui L. Reis, Manuela E. Gomes
Pubblicato in: Advanced Healthcare Materials, Numero 5/11, 2016, Pagina/e 1364-1375, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201501048

Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose‐derived stem cells

Autori: Ana I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes
Pubblicato in: Journal of Tissue Engineering and Regenerative Medicine, Numero 13/12, 2019, Pagina/e 2204-2217, ISSN 1932-6254
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/term.2967

Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies

Autori: Raquel Costa-Almeida, Isabel Calejo, Manuela E. Gomes
Pubblicato in: International Journal of Molecular Sciences, Numero 20/12, 2019, Pagina/e 3002, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20123002

Biphasic Hydrogels Integrating Mineralized and Anisotropic Features for Interfacial Tissue Engineering

Autori: Mari Carmen Echave, Rui M. A. Domingues, Manuel Gómez-Florit, José Luis Pedraz, Rui L. Reis, Gorka Orive, Manuela E. Gomes
Pubblicato in: ACS Applied Materials & Interfaces, Numero 11/51, 2019, Pagina/e 47771-47784, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.9b17826

Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction

Autori: Ana M. Matos, Ana I. Gonçalves, Alicia J. El Haj, Manuela E. Gomes
Pubblicato in: Nanoscale Advances, Numero 2/1, 2020, Pagina/e 140-148, ISSN 2516-0230
Editore: The Royal Society of Chemistry
DOI: 10.1039/c9na00615j

Rebuilding Tendons: A Concise Review on the Potential of Dermal Fibroblasts.

Autori: Jin Chu; Ming Lu; Christian Pfeifer; Volker Alt; Denitsa Docheva
Pubblicato in: Cells, Vol 9, Iss 2047, p 2047 (2020), Numero 1, 2020, ISSN 2073-4409
Editore: MDPI
DOI: 10.5283/epub.44078

Biomaterials for Sequestration of Growth Factors and Modulation of Cell Behavior

Autori: Simão P. B. Teixeira; Rui M. A. Domingues; Mariya Shevchuk; Manuela E. Gomes; Nicholas A. Peppas; Rui L. Reis
Pubblicato in: Advanced Functional Materials, Numero 1, 2020, ISSN 1616-3028
Editore: John Wiley & Sons
DOI: 10.1002/adfm.201909011

Remote triggering of TGF-β/Smad2/3 signaling in human adipose stem cells laden on magnetic scaffolds synergistically promotes tenogenic commitment.

Autori: Ana M. Matos; Ana I. Gonçalves; Márcia T. Rodrigues; Margarida S. Miranda; Alicia J. El Haj; Rui L. Reis; Manuela E. Gomes
Pubblicato in: Acta Biomaterialia, Numero 1, 2020, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2020.07.009

Dental follicle cell differentiation towards periodontal ligament-like tissue in a self-assembly three-dimensional organoid model

Autori: Chu, J., Pieles, O., Pfeifer, C. G., Alt, V., Morsczeck, C., & Docheva, D
Pubblicato in: Biomaterials Science, 2021, ISSN 2047-4849
Editore: Royal Society of Chemistry
DOI: 10.22203/ecm.v042a02

An anisotropic nanocomposite hydrogel guides aligned orientation and enhances tenogenesis of human tendon stem/progenitor cells

Autori: Xu, Y., Yin, H., Chu, J., Eglin, D., Serra, T., & Docheva, D.
Pubblicato in: Biomaterials Science, 2021, ISSN 2047-4849
Editore: Royal Society of Chemistry
DOI: 10.1039/d0bm01127d

Therapeutic Effects of Platelet-Derived Extracellular Vesicles in a Bioengineered Tendon Disease Model

Autori: Rui Domingues; Isabel Calejo; Ana Graça; Manuela Gomes; Manuel Gomez-Florit
Pubblicato in: International Journal of Molecular Sciences; Volume 23; Numero 6; Pages: 2948, Numero 1, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23062948

Human tendon-derived cell sheets created by magnetic force-based tissue engineering hold tenogenic and immunomodulatory potential

Autori: Adriana Vinhas; Ana I. Gonçalves; Márcia T. Rodrigues; Manuela E. Gomes
Pubblicato in: Acta Biomaterialia, Numero 1, 2021, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2021.06.036

Three-dimensional self-assembling nanofiber matrix rejuvenates aged/degenerative human tendon stem/progenitor cells.

Autori: Heyong Yin; Heyong Yin; Franziska Strunz; Zexing Yan; Jiaju Lu; Christoph Brochhausen; Stefanie Kiderlen; Stefanie Kiderlen; Hauke Clausen-Schaumann; Hauke Clausen-Schaumann; Xiumei Wang; Manuela E. Gomes; Volker Alt; Denitsa Docheva
Pubblicato in: Biomaterials, Numero 3, 2020, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.119802

Multiscale multifactorial approaches for engineering tendon substitutes

Autori: Ana I. Gonçalves; Márcia T. Rodrigues; Ana M. Matos; Helena Almeida; Manuel Gómez-Florit; Rui M. A. Domingues; Manuela E. Gomes
Pubblicato in: Organ Tissue Engineering, Numero 1, 2020
Editore: Springer
DOI: 10.1007/978-3-030-18512-1_8-1

Biomaterials as Tendon and Ligament Substitutes: Current Developments

Autori: Mariana L. Santos, Márcia T. Rodrigues, Rui M. A. Domingues, Rui Luís Reis, Manuela E. Gomes
Pubblicato in: Regenerative Strategies for the Treatment of Knee Joint Disabilities, Numero 21/17, 2016, Pagina/e 349-371, ISBN 978-3-319-44783-4
Editore: Springer International Publishing
DOI: 10.1007/978-3-319-44785-8_17

Bioengineered Strategies for Tendon Regeneration

Autori: A.I. Gonçalves, M.T. Rodrigues, R.L. Reis, M.E. Gomes
Pubblicato in: In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design, 2016, Pagina/e 275-293, ISBN 978-0-12-802225-2
Editore: Elsevier
DOI: 10.1016/B978-0-12-802225-2.00015-5

Fabrication of Hierarchical and Biomimetic Fibrous Structures to Support the Regeneration of Tendon Tissues

Autori: Rui M.A. Domingues, Ana I. Gonçalves, Raquel Costa-Almeida, Márcia T. Rodrigues, Rui L. Reis, Manuela E. Gomes
Pubblicato in: Tendon Regeneration, 2015, Pagina/e 259-280, ISBN 9780-128015902
Editore: Elsevier
DOI: 10.1016/B978-0-12-801590-2.00010-7

Cell-Based Approaches for Tendon Regeneration

Autori: Ana I. Gonçalves, Raquel Costa-Almeida, Pavel Gershovich, Márcia T. Rodrigues, Rui L. Reis, Manuela E. Gomes
Pubblicato in: Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes, 2015, Pagina/e 187-203, ISBN 978-0-12-801590-2
Editore: Elsevier
DOI: 10.1016/B978-0-12-801590-2.00006-5

Designing microenvironments for optimal outcomes in tissue engineering and regenerative medicine: From biopolymers to culturing conditions

Autori: Tsiapalis D, Ribeiro S, De Pieri A, Sallent I, Guillaumin S, Gaspar D, Korntner, S, Bayon, Y, Gomes, M E, Reis, R L, Zeugolis, D I
Pubblicato in: Encyclopedia of Tissue Engineering and Regenerative Medicine, 2019, Pagina/e 119-30, ISBN 9780-128136997
Editore: Elsevier, Academic Press

TENDON REGENERATION: Understanding Tissue Physiology and Development to Engineer Functional Substitutes

Autori: Gomes M. E., Reis R. L., and Rodrigues M. T. (eds)
Pubblicato in: 2015, Pagina/e iii, ISBN 978-0-12-801590-2
Editore: Elsevier
DOI: 10.1016/B978-0-12-801590-2.01001-2

DESIGN AND CHARACTERIZATION OF SYNTHETIC BIODEGRADABLE FILMS FOR MUSCULOSKELETAL TISSUE ENGINEERING

Autori: S. Ribeiro, V. Novacek, E.M. Fernandes, M.E. Gomes, R.L. Reis, Y. Bayon, D.I. Zeugolis
Pubblicato in: The Bone & Joint Journal/Orthopaedic Proceedings, 2018, ISSN 2049-4416
Editore: The British Editorial Society of Bone & Joint Surgery

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