Overcoming specific weaknesses in tendon biology to design advanced regenerative therapies

Informacje na temat projektu

Achilles

Identyfikator umowy o grant: 810850

DOI

10.3030/810850

Projekt został zamknięty

Data podpisania przez KE 27 Czerwca 2018

Data rozpoczęcia 1 Października 2018

Data zakończenia 30 Czerwca 2022

Finansowanie w ramach

• Twinning of research institutions

Koszt całkowity

€ 999 626,25

Wkład UE

€ 999 626,25

Koordynowany przez

UNIVERSIDADE DO MINHO
Portugal

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (2)

Outeach report

D43 Outreach Report Report the results and impact of the outreach activities in the first half and end of the project

Achilles good practices and lessons learnt

D51 Achilles good practices and lesson learnt good practices and lessons learnt with regard to the enhancement of STI capacity through collaboration between universities

Open Research Data Pilot (1)

Data Management Plan

Data Management Plan (DPM)

Publikacje

Peer reviewed articles (41)

Hyaluronic acid as macromolecular crowder in equine adipose-derived stem cell cultures

Autorzy: Garnica-Galvez, S., Korntner, S. H., Skoufos, I., Tzora, A., Diakakis, N., Prassinos, N., & Zeugolis, D. I.
Opublikowane w: Cells, 2021, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells10040859

Spectrum of Tendon Pathologies: Triggers, Trails and End-State

Autorzy: Sara Steinmann; Christian Pfeifer; Christoph Brochhausen; Denitsa Docheva
Opublikowane w: International Journal of Molecular Sciences, Numer 1, 2020, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.5283/epub.41519

Magnetic triggers in biomedical applications - prospects for contact free cell sensing and guidance.

Autorzy: Ana Filipa Martins Almeida; Adriana Vinhas; Ana I. Gonçalves; Margarida S. Miranda; Márcia T. Rodrigues; Manuela E. Gomes
Opublikowane w: Journal of Materials Chemistry B, Numer 1, 2021, ISSN 2050-7518
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d0tb02474k

Loss of tenomodulin expression is a risk factor for age‐related intervertebral disc degeneration

Autorzy: Dasheng Lin; Dasheng Lin; Paolo Alberton; Manuel Delgado Caceres; Carina Prein; Hauke Clausen-Schaumann; Jian Dong; Attila Aszodi; Chisa Shukunami; James C. Iatridis; Denitsa Docheva
Opublikowane w: Aging Cell, Numer 1, 2020, ISSN 1474-9726
Wydawca: John Wiley & Sons
DOI: 10.5283/epub.43124

Controlling the fate of regenerative cells with engineered platelet-derived extracellular vesicles

Autorzy: Graça, A. L., Gómez-Florit, M., Osório, H., Rodrigues, M. T., Domingues, R. M., Reis, R. L., & Gomes
Opublikowane w: Nanoscale, 2022, ISSN 2040-3372
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d1nr08108j

Single Cell Bioprinting with Ultrashort Laser Pulses

Autorzy: Jun Zhang; Patrick Byers; Amelie Erben; Amelie Erben; Amelie Erben; Christine Frank; Levin Schulte-Spechtel; Michael Heymann; Michael Heymann; Denitsa Docheva; Heinz P. Huber; Stefanie Sudhop; Stefanie Sudhop; Hauke Clausen-Schaumann; Hauke Clausen-Schaumann
Opublikowane w: Advanced Functional Materials, Numer 1, 2021, ISSN 1616-3028
Wydawca: John Wiley & Sons
DOI: 10.5283/epub.52322

Changes of material elastic properties during healing of ruptured achilles tendons measured with shear wave elastography: A pilot study

Autorzy: Frankewycz, B., Henssler, L., Weber, J., Platz Batista da Silva, N., Koch, M., Jung, E. M., ... & Pfeifer, C. G.
Opublikowane w: International journal of molecular sciences, 2020, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21103427

Modulation of stem cell response using biodegradable polyester films with different stiffness

Autorzy: Sofia Ribeiro; Eugenia Pugliese; Stefanie Korntner; Emanuel M. Fernandes; Manuela E. Gomes; Rui L. Reis; Yves Bayon; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Opublikowane w: Biomedical Engineering Advances, Numer 1, 2021, ISSN 2667-0992
Wydawca: Elsevier
DOI: 10.1016/j.bea.2021.100007

Growth factor and macromolecular crowding supplementation in human tenocyte culture

Autorzy: Tsiapalis, D., Kearns, S., Kelly, J. L., & Zeugolis, D. I.
Opublikowane w: Biomaterials and Biosystems, 2020, ISSN 2666-5344
Wydawca: Elsevier
DOI: 10.1016/j.bbiosy.2021.100009

Development and characterisation of cytocompatible polyester substrates with tunable mechanical properties and degradation rate

Autorzy: Ribeiro, S., Carvalho, A.M., Fernandes, E.M., Gomes, M.E., Reis, R.L., Bayon, Y. and D.I. Zeugolis
Opublikowane w: Acta Biomaterialia, 2021, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2020.11.026

Magnetic responsive materials modulate the inflammatory profile of IL-1β conditioned tendon cells.

Autorzy: Adriana Vinhas; Márcia T. Rodrigues; Ana I. Gonçalves; Rui L. Reis; Manuela E. Gomes
Opublikowane w: Acta Biomaterialia, Numer 1, 2020, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2020.09.028

Aged tendon stem/progenitor cells are less competent to form 3D tendon organoids due to cell autonomous and matrix production deficits

Autorzy: Yan, Z., Yin, H., Brochhausen, C., Pfeifer, C. G., Alt, V., & Docheva, D
Opublikowane w: Frontiers in Bioengineering and Biotechnology, 2020, ISSN 2296-4185
Wydawca: Frontiers Media
DOI: 10.3389/fbioe.2020.00406

Bioengineered 3D Living Fibers as In Vitro Human Tissue Models of Tendon Physiology and Pathology

Autorzy: Calejo I, Labrador-Rached CJ, Gomez-Florit M, Docheva D, Reis RL, Domingues RMA, Gomes ME
Opublikowane w: Adv Healthc Mater, 2022, ISSN 2192-2659
Wydawca: World Scientific
DOI: 10.1002/adhm.202102863

Allogeneic serum and macromolecular crowding maintain native equine tenocyte function in culture

Autorzy: Rampin, A., Skoufos, I., Raghunath, M., Tzora, A., Diakakis, N., Prassinos, N., & Zeugolis, D. I
Opublikowane w: Cells, 2022, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells11091562

Magnetic Nanocomposite Hydrogels for Tissue Engineering: Design Concepts and Remote Actuation Strategies to Control Cell Fate

Autorzy: Alberto Pardo; Manuel Gómez-Florit; Silvia Barbosa; Pablo Taboada; Rui M. A. Domingues; Manuela E. Gomes
Opublikowane w: ACS nano, Numer 1, 2021, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.0c08253

The impact of cryopreservation in signature markers and immunomodulatory profile of tendon and ligament derived cells

Autorzy: Ana I. Gonçalves; Adriana Vinhas; Márcia T. Rodrigues; Manuela E. Gomes
Opublikowane w: Journal of Cellular Physiology, Numer 1, 2022, ISSN 1097-4652
Wydawca: John Wiley & Sons
DOI: 10.1002/jcp.30540

Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon

Autorzy: Delgado Caceres, M., Angerpointner, K., Galler, M., Lin, D., Michel, P. A., Brochhausen, C., ... & Docheva, D
Opublikowane w: Cell Death & Disease, 2021, ISSN 2041-4889
Wydawca: Nature Publishing Group
DOI: 10.1038/s41419-021-04298-z

Epitope‐imprinted nanoparticles as transforming growth factor‐β3 sequestering ligands to modulate stem cell fate

Autorzy: Simão P. B. Teixeira; Rui M. A. Domingues; Pedro S. Babo; Dominika Berdecka; Margarida S. Miranda; Manuela E. Gomes; Nicholas A. Peppas; Rui L. Reis
Opublikowane w: Advanced Functional Materials, Numer 1, 2021, ISSN 1616-3028
Wydawca: John Wiley & Sons
DOI: 10.1002/adfm.202003934

Extending Single Cell Bioprinting from Femtosecond to Picosecond Laser Pulse Durations

Autorzy: Zhang, J., Geiger, Y., Sotier, F., Djordjevic, S., Docheva, D., Sudhop, S., ... & Huber, H. P.
Opublikowane w: Micromachines, 2021, ISSN 2072-666X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi12101172

Triggering the activation of Activin A type II receptor in human adipose stem cells towards tenogenic commitment using mechanomagnetic stimulation

Autorzy: A.I. Gonçalves, M. Rotherham, H. Markides, M.T. Rodrigues, R.L. Reis, M.E. Gomes, A.J. El Haj
Opublikowane w: Nanomedicine: Nanotechnology, Biology and Medicine, Numer 14/4, 2018, Strona(/y) 1149-1159, ISSN 1549-9634
Wydawca: Elsevier BV
DOI: 10.1016/j.nano.2018.02.008

The effects of platelet lysate patches on the activity of tendon-derived cells

Autorzy: Raquel Costa-Almeida, Albina R. Franco, Tamagno Pesqueira, Mariana B. Oliveira, Pedro S. Babo, Isabel B. Leonor, João F. Mano, Rui L. Reis, Manuela E. Gomes
Opublikowane w: Acta Biomaterialia, Numer 68, 2018, Strona(/y) 29-40, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2018.01.006

Cell-laden composite suture threads for repairing damaged tendons

Autorzy: Raquel Costa-Almeida, Rui M.A. Domingues, Afsoon Fallahi, Huseyin Avci, Iman K. Yazdi, Mohsen Akbari, Rui L. Reis, Ali Tamayol, Manuela E. Gomes, Ali Khademhosseini
Opublikowane w: Journal of Tissue Engineering and Regenerative Medicine, Numer 12/4, 2018, Strona(/y) 1039-1048, ISSN 1932-6254
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/term.2605

Tissue-engineered magnetic cell sheet patches for advanced strategies in tendon regeneration

Autorzy: Ana I. Gonçalves, Márcia T. Rodrigues, Manuela E. Gomes
Opublikowane w: Acta Biomaterialia, Numer 63, 2017, Strona(/y) 110-122, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2017.09.014

Multifunctional magnetic-responsive hydrogels to engineer tendon-to-bone interface

Autorzy: Elsa D. Silva, Pedro S. Babo, Raquel Costa-Almeida, Rui M.A. Domingues, Bárbara B. Mendes, Elvira Paz, Paulo Freitas, Márcia T. Rodrigues, Pedro L. Granja, Manuela E. Gomes
Opublikowane w: Nanomedicine: Nanotechnology, Biology and Medicine, Numer 14/7, 2018, Strona(/y) 2375-2385, ISSN 1549-9634
Wydawca: Elsevier BV
DOI: 10.1016/j.nano.2017.06.002

Human adipose tissue-derived tenomodulin positive subpopulation of stem cells: A promising source of tendon progenitor cells

Autorzy: A.I. Gonçalves, P.M. Gershovich, M.T. Rodrigues, R.L. Reis, M.E. Gomes
Opublikowane w: Journal of Tissue Engineering and Regenerative Medicine, Numer 12/3, 2018, Strona(/y) 762-774, ISSN 1932-6254
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/term.2495

In vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing

Autorzy: Lívia Santos, Marta Silva, Ana I. Gonçalves, Tamagno Pesqueira, Márcia T. Rodrigues, Manuela E. Gomes
Opublikowane w: Nanomedicine, Numer 11/9, 2016, Strona(/y) 1107-1122, ISSN 1743-5889
Wydawca: Future Medicine Ltd.
DOI: 10.2217/nnm-2015-0014

3D Mimicry of Native-Tissue-Fiber Architecture Guides Tendon-Derived Cells and Adipose Stem Cells into Artificial Tendon Constructs

Autorzy: Mariana Laranjeira, Rui M. A. Domingues, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes
Opublikowane w: Small, Numer 13/31, 2017, Strona(/y) 1700689, ISSN 1613-6810
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201700689

Exploring the Potential of Starch/Polycaprolactone Aligned Magnetic Responsive Scaffolds for Tendon Regeneration

Autorzy: Ana I. Gonçalves, Márcia T. Rodrigues, Pedro P. Carvalho, Manuel Bañobre-López, Elvira Paz, Paulo Freitas, Manuela E. Gomes
Opublikowane w: Advanced Healthcare Materials, Numer 5/2, 2016, Strona(/y) 213-222, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201500623

Enhancing the Biomechanical Performance of Anisotropic Nanofibrous Scaffolds in Tendon Tissue Engineering: Reinforcement with Cellulose Nanocrystals

Autorzy: Rui M. A. Domingues, Silvia Chiera, Pavel Gershovich, Antonella Motta, Rui L. Reis, Manuela E. Gomes
Opublikowane w: Advanced Healthcare Materials, Numer 5/11, 2016, Strona(/y) 1364-1375, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201501048

Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose‐derived stem cells

Autorzy: Ana I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes
Opublikowane w: Journal of Tissue Engineering and Regenerative Medicine, Numer 13/12, 2019, Strona(/y) 2204-2217, ISSN 1932-6254
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/term.2967

Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies

Autorzy: Raquel Costa-Almeida, Isabel Calejo, Manuela E. Gomes
Opublikowane w: International Journal of Molecular Sciences, Numer 20/12, 2019, Strona(/y) 3002, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20123002

Biphasic Hydrogels Integrating Mineralized and Anisotropic Features for Interfacial Tissue Engineering

Autorzy: Mari Carmen Echave, Rui M. A. Domingues, Manuel Gómez-Florit, José Luis Pedraz, Rui L. Reis, Gorka Orive, Manuela E. Gomes
Opublikowane w: ACS Applied Materials & Interfaces, Numer 11/51, 2019, Strona(/y) 47771-47784, ISSN 1944-8244
Wydawca: American Chemical Society
DOI: 10.1021/acsami.9b17826

Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction

Autorzy: Ana M. Matos, Ana I. Gonçalves, Alicia J. El Haj, Manuela E. Gomes
Opublikowane w: Nanoscale Advances, Numer 2/1, 2020, Strona(/y) 140-148, ISSN 2516-0230
Wydawca: The Royal Society of Chemistry
DOI: 10.1039/c9na00615j

Rebuilding Tendons: A Concise Review on the Potential of Dermal Fibroblasts.

Autorzy: Jin Chu; Ming Lu; Christian Pfeifer; Volker Alt; Denitsa Docheva
Opublikowane w: Cells, Vol 9, Iss 2047, p 2047 (2020), Numer 1, 2020, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.5283/epub.44078

Biomaterials for Sequestration of Growth Factors and Modulation of Cell Behavior

Autorzy: Simão P. B. Teixeira; Rui M. A. Domingues; Mariya Shevchuk; Manuela E. Gomes; Nicholas A. Peppas; Rui L. Reis
Opublikowane w: Advanced Functional Materials, Numer 1, 2020, ISSN 1616-3028
Wydawca: John Wiley & Sons
DOI: 10.1002/adfm.201909011

Remote triggering of TGF-β/Smad2/3 signaling in human adipose stem cells laden on magnetic scaffolds synergistically promotes tenogenic commitment.

Autorzy: Ana M. Matos; Ana I. Gonçalves; Márcia T. Rodrigues; Margarida S. Miranda; Alicia J. El Haj; Rui L. Reis; Manuela E. Gomes
Opublikowane w: Acta Biomaterialia, Numer 1, 2020, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2020.07.009

Dental follicle cell differentiation towards periodontal ligament-like tissue in a self-assembly three-dimensional organoid model

Autorzy: Chu, J., Pieles, O., Pfeifer, C. G., Alt, V., Morsczeck, C., & Docheva, D
Opublikowane w: Biomaterials Science, 2021, ISSN 2047-4849
Wydawca: Royal Society of Chemistry
DOI: 10.22203/ecm.v042a02

An anisotropic nanocomposite hydrogel guides aligned orientation and enhances tenogenesis of human tendon stem/progenitor cells

Autorzy: Xu, Y., Yin, H., Chu, J., Eglin, D., Serra, T., & Docheva, D.
Opublikowane w: Biomaterials Science, 2021, ISSN 2047-4849
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d0bm01127d

Therapeutic Effects of Platelet-Derived Extracellular Vesicles in a Bioengineered Tendon Disease Model

Autorzy: Rui Domingues; Isabel Calejo; Ana Graça; Manuela Gomes; Manuel Gomez-Florit
Opublikowane w: International Journal of Molecular Sciences; Volume 23; Numer 6; Pages: 2948, Numer 1, 2022, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23062948

Human tendon-derived cell sheets created by magnetic force-based tissue engineering hold tenogenic and immunomodulatory potential

Autorzy: Adriana Vinhas; Ana I. Gonçalves; Márcia T. Rodrigues; Manuela E. Gomes
Opublikowane w: Acta Biomaterialia, Numer 1, 2021, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2021.06.036

Three-dimensional self-assembling nanofiber matrix rejuvenates aged/degenerative human tendon stem/progenitor cells.

Autorzy: Heyong Yin; Heyong Yin; Franziska Strunz; Zexing Yan; Jiaju Lu; Christoph Brochhausen; Stefanie Kiderlen; Stefanie Kiderlen; Hauke Clausen-Schaumann; Hauke Clausen-Schaumann; Xiumei Wang; Manuela E. Gomes; Volker Alt; Denitsa Docheva
Opublikowane w: Biomaterials, Numer 3, 2020, ISSN 0142-9612
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.119802

Book chapters (6)

Multiscale multifactorial approaches for engineering tendon substitutes

Autorzy: Ana I. Gonçalves; Márcia T. Rodrigues; Ana M. Matos; Helena Almeida; Manuel Gómez-Florit; Rui M. A. Domingues; Manuela E. Gomes
Opublikowane w: Organ Tissue Engineering, Numer 1, 2020
Wydawca: Springer
DOI: 10.1007/978-3-030-18512-1_8-1

Biomaterials as Tendon and Ligament Substitutes: Current Developments

Autorzy: Mariana L. Santos, Márcia T. Rodrigues, Rui M. A. Domingues, Rui Luís Reis, Manuela E. Gomes
Opublikowane w: Regenerative Strategies for the Treatment of Knee Joint Disabilities, Numer 21/17, 2016, Strona(/y) 349-371, ISBN 978-3-319-44783-4
Wydawca: Springer International Publishing
DOI: 10.1007/978-3-319-44785-8_17

Bioengineered Strategies for Tendon Regeneration

Autorzy: A.I. Gonçalves, M.T. Rodrigues, R.L. Reis, M.E. Gomes
Opublikowane w: In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design, 2016, Strona(/y) 275-293, ISBN 978-0-12-802225-2
Wydawca: Elsevier
DOI: 10.1016/B978-0-12-802225-2.00015-5

Fabrication of Hierarchical and Biomimetic Fibrous Structures to Support the Regeneration of Tendon Tissues

Autorzy: Rui M.A. Domingues, Ana I. Gonçalves, Raquel Costa-Almeida, Márcia T. Rodrigues, Rui L. Reis, Manuela E. Gomes
Opublikowane w: Tendon Regeneration, 2015, Strona(/y) 259-280, ISBN 9780-128015902
Wydawca: Elsevier
DOI: 10.1016/B978-0-12-801590-2.00010-7

Cell-Based Approaches for Tendon Regeneration

Autorzy: Ana I. Gonçalves, Raquel Costa-Almeida, Pavel Gershovich, Márcia T. Rodrigues, Rui L. Reis, Manuela E. Gomes
Opublikowane w: Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes, 2015, Strona(/y) 187-203, ISBN 978-0-12-801590-2
Wydawca: Elsevier
DOI: 10.1016/B978-0-12-801590-2.00006-5

Designing microenvironments for optimal outcomes in tissue engineering and regenerative medicine: From biopolymers to culturing conditions

Autorzy: Tsiapalis D, Ribeiro S, De Pieri A, Sallent I, Guillaumin S, Gaspar D, Korntner, S, Bayon, Y, Gomes, M E, Reis, R L, Zeugolis, D I
Opublikowane w: Encyclopedia of Tissue Engineering and Regenerative Medicine, 2019, Strona(/y) 119-30, ISBN 9780-128136997
Wydawca: Elsevier, Academic Press

Monographic books (1)

TENDON REGENERATION: Understanding Tissue Physiology and Development to Engineer Functional Substitutes

Autorzy: Gomes M. E., Reis R. L., and Rodrigues M. T. (eds)
Opublikowane w: 2015, Strona(/y) iii, ISBN 978-0-12-801590-2
Wydawca: Elsevier
DOI: 10.1016/B978-0-12-801590-2.01001-2

Conference proceedings (1)

DESIGN AND CHARACTERIZATION OF SYNTHETIC BIODEGRADABLE FILMS FOR MUSCULOSKELETAL TISSUE ENGINEERING

Autorzy: S. Ribeiro, V. Novacek, E.M. Fernandes, M.E. Gomes, R.L. Reis, Y. Bayon, D.I. Zeugolis
Opublikowane w: The Bone & Joint Journal/Orthopaedic Proceedings, 2018, ISSN 2049-4416
Wydawca: The British Editorial Society of Bone & Joint Surgery