Overcoming specific weaknesses in tendon biology to design advanced regenerative therapies

Hyaluronic acid as macromolecular crowder in equine adipose-derived stem cell cultures

Autorzy: Garnica-Galvez, S., Korntner, S. H., Skoufos, I., Tzora, A., Diakakis, N., Prassinos, N., & Zeugolis, D. I.
Opublikowane w: Cells, 2021, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells10040859

Spectrum of Tendon Pathologies: Triggers, Trails and End-State

Autorzy: Sara Steinmann; Christian Pfeifer; Christoph Brochhausen; Denitsa Docheva
Opublikowane w: International Journal of Molecular Sciences, Numer 1, 2020, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.5283/epub.41519

Magnetic triggers in biomedical applications - prospects for contact free cell sensing and guidance.

Autorzy: Ana Filipa Martins Almeida; Adriana Vinhas; Ana I. Gonçalves; Margarida S. Miranda; Márcia T. Rodrigues; Manuela E. Gomes
Opublikowane w: Journal of Materials Chemistry B, Numer 1, 2021, ISSN 2050-7518
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d0tb02474k

Loss of tenomodulin expression is a risk factor for age‐related intervertebral disc degeneration

Autorzy: Dasheng Lin; Dasheng Lin; Paolo Alberton; Manuel Delgado Caceres; Carina Prein; Hauke Clausen-Schaumann; Jian Dong; Attila Aszodi; Chisa Shukunami; James C. Iatridis; Denitsa Docheva
Opublikowane w: Aging Cell, Numer 1, 2020, ISSN 1474-9726
Wydawca: John Wiley & Sons
DOI: 10.5283/epub.43124

Controlling the fate of regenerative cells with engineered platelet-derived extracellular vesicles

Autorzy: Graça, A. L., Gómez-Florit, M., Osório, H., Rodrigues, M. T., Domingues, R. M., Reis, R. L., & Gomes
Opublikowane w: Nanoscale, 2022, ISSN 2040-3372
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d1nr08108j

Single Cell Bioprinting with Ultrashort Laser Pulses

Autorzy: Jun Zhang; Patrick Byers; Amelie Erben; Amelie Erben; Amelie Erben; Christine Frank; Levin Schulte-Spechtel; Michael Heymann; Michael Heymann; Denitsa Docheva; Heinz P. Huber; Stefanie Sudhop; Stefanie Sudhop; Hauke Clausen-Schaumann; Hauke Clausen-Schaumann
Opublikowane w: Advanced Functional Materials, Numer 1, 2021, ISSN 1616-3028
Wydawca: John Wiley & Sons
DOI: 10.5283/epub.52322

Changes of material elastic properties during healing of ruptured achilles tendons measured with shear wave elastography: A pilot study

Autorzy: Frankewycz, B., Henssler, L., Weber, J., Platz Batista da Silva, N., Koch, M., Jung, E. M., ... & Pfeifer, C. G.
Opublikowane w: International journal of molecular sciences, 2020, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21103427

Modulation of stem cell response using biodegradable polyester films with different stiffness

Autorzy: Sofia Ribeiro; Eugenia Pugliese; Stefanie Korntner; Emanuel M. Fernandes; Manuela E. Gomes; Rui L. Reis; Yves Bayon; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Opublikowane w: Biomedical Engineering Advances, Numer 1, 2021, ISSN 2667-0992
Wydawca: Elsevier
DOI: 10.1016/j.bea.2021.100007

Growth factor and macromolecular crowding supplementation in human tenocyte culture

Autorzy: Tsiapalis, D., Kearns, S., Kelly, J. L., & Zeugolis, D. I.
Opublikowane w: Biomaterials and Biosystems, 2020, ISSN 2666-5344
Wydawca: Elsevier
DOI: 10.1016/j.bbiosy.2021.100009

Development and characterisation of cytocompatible polyester substrates with tunable mechanical properties and degradation rate

Autorzy: Ribeiro, S., Carvalho, A.M., Fernandes, E.M., Gomes, M.E., Reis, R.L., Bayon, Y. and D.I. Zeugolis
Opublikowane w: Acta Biomaterialia, 2021, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2020.11.026

Magnetic responsive materials modulate the inflammatory profile of IL-1β conditioned tendon cells.

Autorzy: Adriana Vinhas; Márcia T. Rodrigues; Ana I. Gonçalves; Rui L. Reis; Manuela E. Gomes
Opublikowane w: Acta Biomaterialia, Numer 1, 2020, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2020.09.028

Aged tendon stem/progenitor cells are less competent to form 3D tendon organoids due to cell autonomous and matrix production deficits

Autorzy: Yan, Z., Yin, H., Brochhausen, C., Pfeifer, C. G., Alt, V., & Docheva, D
Opublikowane w: Frontiers in Bioengineering and Biotechnology, 2020, ISSN 2296-4185
Wydawca: Frontiers Media
DOI: 10.3389/fbioe.2020.00406

Bioengineered 3D Living Fibers as In Vitro Human Tissue Models of Tendon Physiology and Pathology

Autorzy: Calejo I, Labrador-Rached CJ, Gomez-Florit M, Docheva D, Reis RL, Domingues RMA, Gomes ME
Opublikowane w: Adv Healthc Mater, 2022, ISSN 2192-2659
Wydawca: World Scientific
DOI: 10.1002/adhm.202102863

Allogeneic serum and macromolecular crowding maintain native equine tenocyte function in culture

Autorzy: Rampin, A., Skoufos, I., Raghunath, M., Tzora, A., Diakakis, N., Prassinos, N., & Zeugolis, D. I
Opublikowane w: Cells, 2022, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells11091562

Magnetic Nanocomposite Hydrogels for Tissue Engineering: Design Concepts and Remote Actuation Strategies to Control Cell Fate

Autorzy: Alberto Pardo; Manuel Gómez-Florit; Silvia Barbosa; Pablo Taboada; Rui M. A. Domingues; Manuela E. Gomes
Opublikowane w: ACS nano, Numer 1, 2021, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.0c08253

The impact of cryopreservation in signature markers and immunomodulatory profile of tendon and ligament derived cells

Autorzy: Ana I. Gonçalves; Adriana Vinhas; Márcia T. Rodrigues; Manuela E. Gomes
Opublikowane w: Journal of Cellular Physiology, Numer 1, 2022, ISSN 1097-4652
Wydawca: John Wiley & Sons
DOI: 10.1002/jcp.30540

Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon

Autorzy: Delgado Caceres, M., Angerpointner, K., Galler, M., Lin, D., Michel, P. A., Brochhausen, C., ... & Docheva, D
Opublikowane w: Cell Death & Disease, 2021, ISSN 2041-4889
Wydawca: Nature Publishing Group
DOI: 10.1038/s41419-021-04298-z

Epitope‐imprinted nanoparticles as transforming growth factor‐β3 sequestering ligands to modulate stem cell fate

Autorzy: Simão P. B. Teixeira; Rui M. A. Domingues; Pedro S. Babo; Dominika Berdecka; Margarida S. Miranda; Manuela E. Gomes; Nicholas A. Peppas; Rui L. Reis
Opublikowane w: Advanced Functional Materials, Numer 1, 2021, ISSN 1616-3028
Wydawca: John Wiley & Sons
DOI: 10.1002/adfm.202003934

Extending Single Cell Bioprinting from Femtosecond to Picosecond Laser Pulse Durations

Autorzy: Zhang, J., Geiger, Y., Sotier, F., Djordjevic, S., Docheva, D., Sudhop, S., ... & Huber, H. P.
Opublikowane w: Micromachines, 2021, ISSN 2072-666X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi12101172

Triggering the activation of Activin A type II receptor in human adipose stem cells towards tenogenic commitment using mechanomagnetic stimulation

Autorzy: A.I. Gonçalves, M. Rotherham, H. Markides, M.T. Rodrigues, R.L. Reis, M.E. Gomes, A.J. El Haj
Opublikowane w: Nanomedicine: Nanotechnology, Biology and Medicine, Numer 14/4, 2018, Strona(/y) 1149-1159, ISSN 1549-9634
Wydawca: Elsevier BV
DOI: 10.1016/j.nano.2018.02.008

The effects of platelet lysate patches on the activity of tendon-derived cells

Autorzy: Raquel Costa-Almeida, Albina R. Franco, Tamagno Pesqueira, Mariana B. Oliveira, Pedro S. Babo, Isabel B. Leonor, João F. Mano, Rui L. Reis, Manuela E. Gomes
Opublikowane w: Acta Biomaterialia, Numer 68, 2018, Strona(/y) 29-40, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2018.01.006

Cell-laden composite suture threads for repairing damaged tendons

Autorzy: Raquel Costa-Almeida, Rui M.A. Domingues, Afsoon Fallahi, Huseyin Avci, Iman K. Yazdi, Mohsen Akbari, Rui L. Reis, Ali Tamayol, Manuela E. Gomes, Ali Khademhosseini
Opublikowane w: Journal of Tissue Engineering and Regenerative Medicine, Numer 12/4, 2018, Strona(/y) 1039-1048, ISSN 1932-6254
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/term.2605

Tissue-engineered magnetic cell sheet patches for advanced strategies in tendon regeneration

Autorzy: Ana I. Gonçalves, Márcia T. Rodrigues, Manuela E. Gomes
Opublikowane w: Acta Biomaterialia, Numer 63, 2017, Strona(/y) 110-122, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2017.09.014

Multifunctional magnetic-responsive hydrogels to engineer tendon-to-bone interface

Autorzy: Elsa D. Silva, Pedro S. Babo, Raquel Costa-Almeida, Rui M.A. Domingues, Bárbara B. Mendes, Elvira Paz, Paulo Freitas, Márcia T. Rodrigues, Pedro L. Granja, Manuela E. Gomes
Opublikowane w: Nanomedicine: Nanotechnology, Biology and Medicine, Numer 14/7, 2018, Strona(/y) 2375-2385, ISSN 1549-9634
Wydawca: Elsevier BV
DOI: 10.1016/j.nano.2017.06.002

Human adipose tissue-derived tenomodulin positive subpopulation of stem cells: A promising source of tendon progenitor cells

Autorzy: A.I. Gonçalves, P.M. Gershovich, M.T. Rodrigues, R.L. Reis, M.E. Gomes
Opublikowane w: Journal of Tissue Engineering and Regenerative Medicine, Numer 12/3, 2018, Strona(/y) 762-774, ISSN 1932-6254
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/term.2495

In vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing

Autorzy: Lívia Santos, Marta Silva, Ana I. Gonçalves, Tamagno Pesqueira, Márcia T. Rodrigues, Manuela E. Gomes
Opublikowane w: Nanomedicine, Numer 11/9, 2016, Strona(/y) 1107-1122, ISSN 1743-5889
Wydawca: Future Medicine Ltd.
DOI: 10.2217/nnm-2015-0014

3D Mimicry of Native-Tissue-Fiber Architecture Guides Tendon-Derived Cells and Adipose Stem Cells into Artificial Tendon Constructs

Autorzy: Mariana Laranjeira, Rui M. A. Domingues, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes
Opublikowane w: Small, Numer 13/31, 2017, Strona(/y) 1700689, ISSN 1613-6810
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201700689

Exploring the Potential of Starch/Polycaprolactone Aligned Magnetic Responsive Scaffolds for Tendon Regeneration

Autorzy: Ana I. Gonçalves, Márcia T. Rodrigues, Pedro P. Carvalho, Manuel Bañobre-López, Elvira Paz, Paulo Freitas, Manuela E. Gomes
Opublikowane w: Advanced Healthcare Materials, Numer 5/2, 2016, Strona(/y) 213-222, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201500623

Enhancing the Biomechanical Performance of Anisotropic Nanofibrous Scaffolds in Tendon Tissue Engineering: Reinforcement with Cellulose Nanocrystals

Autorzy: Rui M. A. Domingues, Silvia Chiera, Pavel Gershovich, Antonella Motta, Rui L. Reis, Manuela E. Gomes
Opublikowane w: Advanced Healthcare Materials, Numer 5/11, 2016, Strona(/y) 1364-1375, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201501048

Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose‐derived stem cells

Autorzy: Ana I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes
Opublikowane w: Journal of Tissue Engineering and Regenerative Medicine, Numer 13/12, 2019, Strona(/y) 2204-2217, ISSN 1932-6254
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/term.2967

Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies

Autorzy: Raquel Costa-Almeida, Isabel Calejo, Manuela E. Gomes
Opublikowane w: International Journal of Molecular Sciences, Numer 20/12, 2019, Strona(/y) 3002, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20123002

Biphasic Hydrogels Integrating Mineralized and Anisotropic Features for Interfacial Tissue Engineering

Autorzy: Mari Carmen Echave, Rui M. A. Domingues, Manuel Gómez-Florit, José Luis Pedraz, Rui L. Reis, Gorka Orive, Manuela E. Gomes
Opublikowane w: ACS Applied Materials & Interfaces, Numer 11/51, 2019, Strona(/y) 47771-47784, ISSN 1944-8244
Wydawca: American Chemical Society
DOI: 10.1021/acsami.9b17826

Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction

Autorzy: Ana M. Matos, Ana I. Gonçalves, Alicia J. El Haj, Manuela E. Gomes
Opublikowane w: Nanoscale Advances, Numer 2/1, 2020, Strona(/y) 140-148, ISSN 2516-0230
Wydawca: The Royal Society of Chemistry
DOI: 10.1039/c9na00615j

Rebuilding Tendons: A Concise Review on the Potential of Dermal Fibroblasts.

Autorzy: Jin Chu; Ming Lu; Christian Pfeifer; Volker Alt; Denitsa Docheva
Opublikowane w: Cells, Vol 9, Iss 2047, p 2047 (2020), Numer 1, 2020, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.5283/epub.44078

Biomaterials for Sequestration of Growth Factors and Modulation of Cell Behavior

Autorzy: Simão P. B. Teixeira; Rui M. A. Domingues; Mariya Shevchuk; Manuela E. Gomes; Nicholas A. Peppas; Rui L. Reis
Opublikowane w: Advanced Functional Materials, Numer 1, 2020, ISSN 1616-3028
Wydawca: John Wiley & Sons
DOI: 10.1002/adfm.201909011

Remote triggering of TGF-β/Smad2/3 signaling in human adipose stem cells laden on magnetic scaffolds synergistically promotes tenogenic commitment.

Autorzy: Ana M. Matos; Ana I. Gonçalves; Márcia T. Rodrigues; Margarida S. Miranda; Alicia J. El Haj; Rui L. Reis; Manuela E. Gomes
Opublikowane w: Acta Biomaterialia, Numer 1, 2020, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2020.07.009

Dental follicle cell differentiation towards periodontal ligament-like tissue in a self-assembly three-dimensional organoid model

Autorzy: Chu, J., Pieles, O., Pfeifer, C. G., Alt, V., Morsczeck, C., & Docheva, D
Opublikowane w: Biomaterials Science, 2021, ISSN 2047-4849
Wydawca: Royal Society of Chemistry
DOI: 10.22203/ecm.v042a02

An anisotropic nanocomposite hydrogel guides aligned orientation and enhances tenogenesis of human tendon stem/progenitor cells

Autorzy: Xu, Y., Yin, H., Chu, J., Eglin, D., Serra, T., & Docheva, D.
Opublikowane w: Biomaterials Science, 2021, ISSN 2047-4849
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d0bm01127d

Therapeutic Effects of Platelet-Derived Extracellular Vesicles in a Bioengineered Tendon Disease Model

Autorzy: Rui Domingues; Isabel Calejo; Ana Graça; Manuela Gomes; Manuel Gomez-Florit
Opublikowane w: International Journal of Molecular Sciences; Volume 23; Numer 6; Pages: 2948, Numer 1, 2022, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23062948

Human tendon-derived cell sheets created by magnetic force-based tissue engineering hold tenogenic and immunomodulatory potential

Autorzy: Adriana Vinhas; Ana I. Gonçalves; Márcia T. Rodrigues; Manuela E. Gomes
Opublikowane w: Acta Biomaterialia, Numer 1, 2021, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2021.06.036

Three-dimensional self-assembling nanofiber matrix rejuvenates aged/degenerative human tendon stem/progenitor cells.

Autorzy: Heyong Yin; Heyong Yin; Franziska Strunz; Zexing Yan; Jiaju Lu; Christoph Brochhausen; Stefanie Kiderlen; Stefanie Kiderlen; Hauke Clausen-Schaumann; Hauke Clausen-Schaumann; Xiumei Wang; Manuela E. Gomes; Volker Alt; Denitsa Docheva
Opublikowane w: Biomaterials, Numer 3, 2020, ISSN 0142-9612
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.119802

Multiscale multifactorial approaches for engineering tendon substitutes

Autorzy: Ana I. Gonçalves; Márcia T. Rodrigues; Ana M. Matos; Helena Almeida; Manuel Gómez-Florit; Rui M. A. Domingues; Manuela E. Gomes
Opublikowane w: Organ Tissue Engineering, Numer 1, 2020
Wydawca: Springer
DOI: 10.1007/978-3-030-18512-1_8-1

Biomaterials as Tendon and Ligament Substitutes: Current Developments

Autorzy: Mariana L. Santos, Márcia T. Rodrigues, Rui M. A. Domingues, Rui Luís Reis, Manuela E. Gomes
Opublikowane w: Regenerative Strategies for the Treatment of Knee Joint Disabilities, Numer 21/17, 2016, Strona(/y) 349-371, ISBN 978-3-319-44783-4
Wydawca: Springer International Publishing
DOI: 10.1007/978-3-319-44785-8_17

Bioengineered Strategies for Tendon Regeneration

Autorzy: A.I. Gonçalves, M.T. Rodrigues, R.L. Reis, M.E. Gomes
Opublikowane w: In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design, 2016, Strona(/y) 275-293, ISBN 978-0-12-802225-2
Wydawca: Elsevier
DOI: 10.1016/B978-0-12-802225-2.00015-5

Fabrication of Hierarchical and Biomimetic Fibrous Structures to Support the Regeneration of Tendon Tissues

Autorzy: Rui M.A. Domingues, Ana I. Gonçalves, Raquel Costa-Almeida, Márcia T. Rodrigues, Rui L. Reis, Manuela E. Gomes
Opublikowane w: Tendon Regeneration, 2015, Strona(/y) 259-280, ISBN 9780-128015902
Wydawca: Elsevier
DOI: 10.1016/B978-0-12-801590-2.00010-7

Cell-Based Approaches for Tendon Regeneration

Autorzy: Ana I. Gonçalves, Raquel Costa-Almeida, Pavel Gershovich, Márcia T. Rodrigues, Rui L. Reis, Manuela E. Gomes
Opublikowane w: Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes, 2015, Strona(/y) 187-203, ISBN 978-0-12-801590-2
Wydawca: Elsevier
DOI: 10.1016/B978-0-12-801590-2.00006-5

Designing microenvironments for optimal outcomes in tissue engineering and regenerative medicine: From biopolymers to culturing conditions

Autorzy: Tsiapalis D, Ribeiro S, De Pieri A, Sallent I, Guillaumin S, Gaspar D, Korntner, S, Bayon, Y, Gomes, M E, Reis, R L, Zeugolis, D I
Opublikowane w: Encyclopedia of Tissue Engineering and Regenerative Medicine, 2019, Strona(/y) 119-30, ISBN 9780-128136997
Wydawca: Elsevier, Academic Press

TENDON REGENERATION: Understanding Tissue Physiology and Development to Engineer Functional Substitutes

Autorzy: Gomes M. E., Reis R. L., and Rodrigues M. T. (eds)
Opublikowane w: 2015, Strona(/y) iii, ISBN 978-0-12-801590-2
Wydawca: Elsevier
DOI: 10.1016/B978-0-12-801590-2.01001-2

DESIGN AND CHARACTERIZATION OF SYNTHETIC BIODEGRADABLE FILMS FOR MUSCULOSKELETAL TISSUE ENGINEERING

Autorzy: S. Ribeiro, V. Novacek, E.M. Fernandes, M.E. Gomes, R.L. Reis, Y. Bayon, D.I. Zeugolis
Opublikowane w: The Bone & Joint Journal/Orthopaedic Proceedings, 2018, ISSN 2049-4416
Wydawca: The British Editorial Society of Bone & Joint Surgery

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