Descrizione del progetto
Un programma di formazione su organoidi innovativi per studi sulle infezioni virali
Gli approcci comuni allo studio delle infezioni virali comprendono l’uso di modelli animali e colture cellulari bidimensionali. Nel caso delle infezioni virali umane, tuttavia, gli effetti a valle e secondari provocati dai virus non possono essere completamente analizzati utilizzando tali modelli. Il progetto OrganoVIR, finanziato dal programma di azioni Marie Skłodowska-Curie, svilupperà una rete di formazione sulla ricerca per esaminare l’infezione virale umana in colture cellulari tridimensionali (organoidi). L’obiettivo è definire organoidi umani come modelli superiori per studi di patogenesi virale e test antivirali, sostituendo i modelli animali. Questo programma formerà giovani ricercatori e ricercatrici sugli aspetti scientifici e tecnici degli organoidi per la ricerca sui virus, nonché sugli aspetti finanziari, etici, commerciali e legali della tecnologia degli organoidi.
Obiettivo
OrganoVIR (Organoids for Virus Research) will train young researchers (ESRs) in the field of organoids and virology. Human viral infection studies lack suitable experimental models as animal models or conventional 2-dimensional (2D) cell cultures do not translate to human infection. OrganoVIR makes use of the breakthrough in the culturing of primary human cells into 3D cultures (organoids). Within this ETN programme, organoids will be used for the first time to study human viral infections in their natural environment.
OrganoVIR includes leading partners in virology and organoid technology covering 7 academic institutes, 3 life science companies, 1 organoid technology private company, 2 non-profit organisations, a national public health institute and a business school originating from 8 countries.
The aim is to introduce and establish human organoids as superior models for viral pathogenesis studies and antiviral testing, thus replacing animal models and reducing animal use. OrganoVIR provides a full package ETN programme for ESRs to learn the science of innovative 3D culture systems for virus research as well as financial, commercial, ethical, communicative, policy and dissemination aspects for optimal valorization. The projects are intensified by significant secondments at commercial, governmental and non-profit partner institutes.
OrganoVIR provides:
- High-ranked scientific and technical training in an interdisciplinary, intersectoral and international top research project
- Training in transferrable managerial skills, including a pre-MBA
- Implementation of innovative organoid technology for viral pathogenesis studies and antiviral development
- Innovation in organoid technology by co-culture design and high throughput screening.
OrganoVIR combines frontier research with an innovative training programme in a complementary network, certifying high impact scientists.
Campo scientifico
Parole chiave
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Meccanismo di finanziamento
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinatore
1105AZ Amsterdam
Paesi Bassi