Targeting the epigenome: towards a better understanding of disease pathogenesis and novel therapeutic strategies in Multiple Sclerosis

Smoking affects epigenetic ageing of lung bronchoalveolar lavage cells in Multiple Sclerosis

Autori: Dennis Klose, Maria Needhamsen, Mikael V. Ringh, Michael Hagemann-Jensen, Maja Jagodic, Lara Kular
Pubblicato in: Multiple Sclerosis and Related Disorders, Numero 79, 2024, Pagina/e 104991, ISSN 2211-0348
Editore: Elsevier
DOI: 10.1016/j.msard.2023.104991

T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis

Autori: Ivan Jelcic, Reza Naghavian, Imran Fanaswala, Will Macnair, Cinzia Esposito, Daniela Calini, Yanan Han, Zoe Marti, Catarina Raposo, Jacobo Sarabia del Castillo, Pietro Oldrati, Daniel Erny, Veronika Kana, Galina Zheleznyakova, Faiez Al Nimer, Björn Tackenberg, Ina Reichen, Mohsen Khademi, Fredrik Piehl, Mark D. Robinson, Ilijas Jelcic, Mireia Sospedra, Lucas Pelkmans, Dheeraj Malhotra, Richard Re
Pubblicato in: Cell Reports Medicine, Numero 6, 2025, Pagina/e 102027, ISSN 2666-3791
Editore: Elsevier BV
DOI: 10.1016/j.xcrm.2025.102027

Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS

Autori: Farina Windener, Laureen Grewing, Christian Thomas, Marie-France Dorion, Marie Otteken, Lara Kular, Maja Jagodic, Jack Antel, Stefanie Albrecht, Tanja Kuhlmann
Pubblicato in: Acta Neuropathologica, Numero 147, 2024, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-024-02733-x

Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis

Autori: Olivia G. Thomas, Urszula Rykaczewska, Marina Galešić, Rianne T.M. van der Burgt, Nils Hallén, Filippo Ferro, Mattias Bronge, Zoe Marti, Yue Li, Alexandra Hill Riqué, Jianing Lin, Aleksa Krstic, Alicja Gromadzka, András Levente Szonder, Chiara Sorini, María Reina-Campos, Ting Sun, Leslie A. Rubio Rodríguez-Kirby, Özge Dumral, Rasmus Berglund, Majid Pahlevan Kakhki, Milena Z. Adzemovic, Man
Pubblicato in: Cell, Numero 189, 2026, Pagina/e 585-602.e38, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2025.12.032

The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology

Autori: Mathias Linnerbauer, Lena Lößlein, Oliver Vandrey, Anne Peter, Yanan Han, Thanos Tsaktanis, Emile Wogram, Maria Needhamsen, Lara Kular, Lisa Nagel, Julia Zissler, Marie Andert, Lisa Meszaros, Jannis Hanspach, Finnja Zuber, Ulrike J. Naumann, Martin Diebold, Michael A. Wheeler, Tobias Beyer, Lucy Nirschl, Ana Cirac, Frederik B. Laun, Claudia Günther, Jürgen Winkler, Tobias Bäuerle, Maja Jagodi
Pubblicato in: Nature Immunology, Numero 25, 2024, Pagina/e 432-447, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-024-01756-6

Epigenetic insights into multiple sclerosis disease progression

Autori: Lara Kular, Maja Jagodic
Pubblicato in: Journal of Internal Medicine, 2020, ISSN 1365-2796
Editore: Oxford : Blackwell Scientific Publications
DOI: 10.1111/joim.13045

Single-nuclei histone modification profiling of the adult human central nervous system unveils epigenetic memory of developmental programs

Autori: Mukund Kabbe, Eneritz Agirre, Karl E. Carlström, Fabio Baldivia Pohl, Nicolas Ruffin, David van Bruggen, Mandy Meijer, Luise A. Seeker, Nadine Bestard-Cuche, Alex R. Lederer, Jilin Zhang, Virpi Ahola, Steven A. Goldman, Marek Bartosovic, Maja Jagodic, Anna Williams, Gonçalo Castelo-Branco
Pubblicato in: Nature Neuroscience [accepted 12th January 2026], 2026, ISSN 1546-1726
Editore: Nature Portfolio
DOI: 10.1101/2024.04.15.589512

Comprehensive profiling of CRISPR/dCas9 epigenome editors indicates a complex link between on and off target effects

Autori: Majid Pahlevan Kakhki, Fatemeh Rangani, Ewoud Ewing, Chiara Starvaggi Cucuzza, Galina Zheleznyakova, Maria Kalomoiri, Lea Kenny, Anika Raghavan, Chandana Rao Prakash, Gabe van den Hoeven, Tejaswi Venkata S. Badam, Ruxandra Covacu, Ioanna Andreou, Maria Needhamsen, Lara Kular, Maja Jagodic
Pubblicato in: Genome Biology, Numero 27, 2026, ISSN 1474-760X
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s13059-026-03967-6

Epigenetic clock indicates accelerated aging in glial cells of progressive multiple sclerosis patients

Autori: Lara Kular, Dennis Klose, Amaya Urdánoz-Casado, Ewoud Ewing, Nuria Planell, David Gomez-Cabrero, Maria Needhamsen, Maja Jagodic
Pubblicato in: Frontiers in Aging Neuroscience, Numero 14, 2022, ISSN 1663-4365
Editore: Frontiers Research Foundation
DOI: 10.3389/fnagi.2022.926468

DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patients

Autori: Lara Kular, Ewoud Ewing, Maria Needhamsen, Majid Pahlevan Kakhki, Ruxandra Covacu, David Gomez-Cabrero, Lou Brundin, Maja Jagodic
Pubblicato in: Epigenetics, 2021, ISSN 1559-2308
Editore: Philadelphia, PA : Taylor & Francis
DOI: 10.1080/15592294.2021.2020436

Comparison of EM-seq and PBAT methylome library methods for low-input DNA

Autori: Yanan Han, Galina Yurevna Zheleznyakova, Yanara Marincevic-Zuniga, Majid Pahlevan Kakhki, Amanda Raine, Maria Needhamsen, Maja Jagodic
Pubblicato in: Epigenetics, 2021, ISSN 1559-2308
Editore: Philadelphia, PA : Taylor & Francis
DOI: 10.1080/15592294.2021.1997406

A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis

Autori: Majid Pahlevan Kakhki, Antonino Giordano, Chiara Starvaggi Cucuzza, Tejaswi Venkata S. Badam, Samudyata Samudyata, Marianne Victoria Lemée, Pernilla Stridh, Asimenia Gkogka, Klementy Shchetynsky, Adil Harroud, Alexandra Gyllenberg, Yun Liu, Sanjaykumar Boddul, Tojo James, Melissa Sorosina, Massimo Filippi, Federica Esposito, Fredrik Wermeling, Mika Gustafsson, Patrizia Casaccia, Jan Hillert, Toma
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-50794-z

Evaluation of Cell-Specific Epigenetic Age Acceleration in People With Multiple Sclerosis

Autori: Vicki Maltby, Alexandre Xavier, Ewoud Ewing, Maria-Pia Campagna, Sandeep Sampangi, Rodney J. Scott, Helmut Butzkueven, Vilija Jokubaitis, Lara Kular, Steffan Bos, Mark Slee, Ingrid A. van der Mei, Bruce V. Taylor, Anne-Louise Ponsonby, Maja Jagodic, Rodney Lea, Jeannette Lechner-Scott
Pubblicato in: Neurology, Numero 101, 2024, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000207489

Locus for severity implicates CNS resilience in progression of multiple sclerosis

Autori: null null, Adil Harroud, Pernilla Stridh, Jacob L. McCauley, Janna Saarela, Aletta M. R. van den Bosch, Hendrik J. Engelenburg, Ashley H. Beecham, Lars Alfredsson, Katayoun Alikhani, Lilyana Amezcua, Till F. M. Andlauer, Maria Ban, Lisa F. Barcellos, Nadia Barizzone, Tone Berge, Achim Berthele, Stefan Bittner, Steffan D. Bos, Farren B. S. Briggs, Stacy J. Caillier, Peter A. Calabresi, Domenico Cap
Pubblicato in: Nature, Numero 619, 2023, Pagina/e 323-331, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-023-06250-x

Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation

Autori: Rasmus Berglund, Andre Ortlieb Guerreiro-Cacais, Milena Z Adzemovic, Manuel Zeitelhofer, Harald Lund, Ewoud Ewing, Sabrina Ruhrmann, Erik Nutma, Roham Parsa, Melanie Thessen-Hedreul, Sandra Amor, Robert A Harris, Tomas Olsson, Maja Jagodic
Pubblicato in: Science Immunology, 2020, ISSN 2470-9468
Editore: Washington, DC : American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.abb5077

Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis

Autori: Karl E. Carlström, Keying Zhu, Ewoud Ewing, Inge E. Krabbendam, Robert A. Harris, Ana Mendanha Falcão, Maja Jagodic, Gonçalo Castelo-Branco, Fredrik Piehl
Pubblicato in: Nature Communications, Numero 11, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-17871-5

A HIF1A variant impacts long-term disability and smoldering inflammation in multiple sclerosis

Autori: Antonino Giordano, Pernilla Stridh, Paolo Preziosa, Marco Pisa, Celia Lerma-Martin, Melissa Sorosina, Elisabetta Mascia, Silvia Santoro, Kaalindi Misra, Ferdinando Clarelli, Laura Ferrè, Maria Needhamsen, Ali Manouchehrinia, Matteo Missaglia, Thomas Moridi, Klementy Shchetynsky, Russell Ouellette, Adil Harroud, Elisabeth de Vries, Subita Balaram Kuttikkatte, Fredrik Piehl, Lars Alfredsson, Jan Hi
Pubblicato in: Acta Neuropathologica, Numero 151, 2026, ISSN 1432-0533
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s00401-026-02984-w

Sustained Low Relapse Rate With Highly Variable B-Cell Repopulation Dynamics With Extended Rituximab Dosing Intervals in Multiple Sclerosis

Autori: Chiara Starvaggi Cucuzza, Elisa Longinetti, Nicolas Ruffin, Björn Evertsson, Ingrid Kockum, Maja Jagodic, Faiez Al Nimer, Thomas Frisell, Fredrik Piehl
Pubblicato in: Neurology Neuroimmunology & Neuroinflammation, Numero 10, 2024, ISSN 2332-7812
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/nxi.0000000000200056

Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology

Autori: Galina Yurevna Zheleznyakova; Eliane Piket; Maria Needhamsen; Michael Hagemann-Jensen; Diana Ekman; Yanan Han; Tojo James; Mohsen Khademi; Faiez Al Nimer; Patrick Scicluna; Jesse Huang; Ingrid Kockum; Omid R. Faridani; Tomas Olsson; Fredrik Piehl; Maja Jagodic
Pubblicato in: Proceedings of the National Academy of Sciences of the United States of America, 2021, ISSN 1091-6490
Editore: Washington, DC : National Academy of Sciences
DOI: 10.1073/pnas.2011574118

Locus for severity implicates CNS resilience in progression of multiple sclerosis

Autori: null null, Adil Harroud, Pernilla Stridh, Jacob L. McCauley, Janna Saarela, Aletta M. R. van den Bosch, Hendrik J. Engelenburg, Ashley H. Beecham, Lars Alfredsson, Katayoun Alikhani, Lilyana Amezcua, Till F. M. Andlauer, Maria Ban, Lisa F. Barcellos, Nadia Barizzone, Tone Berge, Achim Berthele, Stefan Bittner, Steffan D. Bos, Farren B. S. Briggs, Stacy J. Caillier, Peter A. Calabresi, Domenico Cap
Pubblicato in: Nature, Numero 619, 2023, Pagina/e 323-331, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-023-06250-x

A validated generally applicable approach using the systematic assessment of disease modules by GWAS reveals a multi-omic module strongly associated with risk factors in multiple sclerosis

Autori: Tejaswi V S Badam, Hendrik A de Weerd, David Martínez-Enguita, Tomas Olsson, Lars Alfredsson, Ingrid Kockum, Maja Jagodic, Zelmina Lubovac-Pilav, Mika Gustafsson
Pubblicato in: BMC Genomics, 2021, ISSN 1471-2164
Editore: BioMed Central
DOI: 10.1186/s12864-021-07935-1

GeneSetCluster: a tool for summarizing and integrating gene-set analysis results

Autori: Ewoud Ewing, Nuria Planell-Picola, Maja Jagodic, David Gomez-Cabrero
Pubblicato in: BMC Bioinformatics, Numero 21, 2021, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/s12859-020-03784-z

Different epigenetic clocks reflect distinct pathophysiological features of multiple sclerosis

Autori: Eleftheria Theodoropoulou, Lars Alfredsson, Fredrik Piehl, Francesco Marabita, Maja Jagodic
Pubblicato in: Epigenomics, Numero 11, 2024, Pagina/e 1429-1439, ISSN 1750-1911
Editore: Future Medicine Ltd.
DOI: 10.2217/epi-2019-0102

C-type lectin receptors Mcl and Mincle control development of multiple sclerosis–like neuroinflammation

Autori: Marie N’diaye, Susanna Brauner, Sevasti Flytzani, Lara Kular, Andreas Warnecke, Milena Z. Adzemovic, Eliane Piket, Jin-Hong Min, Will Edwards, Filia Mela, Hoi Ying Choi, Vera Magg, Tojo James, Magdalena Linden, Holger M. Reichardt, Michael R. Daws, Jack van Horssen, Ingrid Kockum, Robert A. Harris, Tomas Olsson, Andre O. Guerreiro-Cacais, Maja Jagodic
Pubblicato in: Journal of Clinical Investigation, Numero 130, 2023, Pagina/e 838-852, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci125857

Integration of small RNAs from plasma and cerebrospinal fluid for classification of multiple sclerosis

Autori: Maria Needhamsen, Payam Emami Khoonsari, Galina Yurevna Zheleznyakova, Eliane Piket, Michael Hagemann-Jensen, Yanan Han, Jannik Gierlich, Diana Ekman, Maja Jagodic
Pubblicato in: Frontiers in Genetics, Numero 13, 2022, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2022.1042483

The aging mouse CNS is protected by an autophagy-dependent microglia population promoted by IL-34

Autori: Rasmus Berglund, Yufei Cheng, Eliane Piket, Milena Z. Adzemovic, Manuel Zeitelhofer, Tomas Olsson, Andre Ortlieb Guerreiro-Cacais, Maja Jagodic
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-44556-6

Simultaneous detection of DNA variation and methylation at HLA class II locus and immune gene promoters using targeted SureSelect Methyl-Sequencing

Autori: Maria Kalomoiri, Chandana Rao Prakash, Sonja Lagström, Kai Hauschulz, Ewoud Ewing, Klementy Shchetynsky, Lara Kular, Maria Needhamsen, Maja Jagodic
Pubblicato in: Frontiers in Immunology, Numero 14, 2023, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1251772

DNA Methylation in Multiple Sclerosis

Autori: Lara Kular, Maja Jagodic
Pubblicato in: RNA Technologies, The DNA, RNA, and Histone Methylomes, 2021, Pagina/e 181-214
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-14792-1_8

Epigenetics and multiple sclerosis

Autori: Lara Kular, Gonçalo Castelo-Branco, Maja Jagodic
Pubblicato in: Neuropsychiatric Disorders and Epigenetics, 2024, ISBN 9780443185175
Editore: Academic Press

Oligodendroglia as functional effectors of Multiple Sclerosis risk variants

Autori: Karl E Carlström, Eneritz Agirre, Ting Sun, Özge Dumral, Mukund Kabbe, Neemat Mahmud, Yuk Kit Lor, Majid Pahlevan Kakhki, Mohsen Khademi, Maja Jagodic, Steve A. Goldman, Gonçalo Castelo-Branco
Pubblicato in: bioRxiv, 2026
Editore: openRxiv
DOI: 10.1101/2025.11.11.687640

Epigenomic profiling of cerebrospinal fluid cells identifies immune regulatory alterations and implicates protocadherins in multiple sclerosis

Autori: Yanan Han, Galina Yurevna Zheleznyakova, Chiara Sorini, Majid Pahlevan Kakhki, Nicolas Ruffin, Heng Liang, Nils Hallen, Chandana Rao Prakash, Viveca Beckers, Elena Ivanova, Mohsen Khademi, Mikael C. I. Karlsson, Fredrik Piehl, Tomas Olsson, Gavin Kelsey, Lara Kular, Maria Needhamsen, Maja Jagodic
Pubblicato in: bioRxiv, 2026
Editore: openRxiv
DOI: 10.64898/2026.02.25.708054

Whole-genome profiling of native 5-hydroxymethylation in human neurons with long-read sequencing

Autori: Dennis Klose, Mohammad Hossein Sepehri, Remi-André Olsen, Ha Vu, Jason Ernst, Lara Kular, Maria Needhamsen, Maja Jagodic
Pubblicato in: bioRxiv, 2026
Editore: openRxiv
DOI: 10.64898/2026.01.11.695537

Targeted DNA methylation editing in vivo

Autori: Maria Kalomoiri, Chiara Sorini, Sebastiaan Volkert Timotheus Vos, Anderson Camargo, Chandana Rao Prakash, Per Svenningsson, Majid Pahlevan Kakhki, Lara Kular, Maja Jagodic
Pubblicato in: bioRxiv, 2026
Editore: openRxiv
DOI: 10.64898/2026.02.26.708277

Tackling neuronal stress and neuroinflammation to prevent side effects of brain radiotherapy

Autori: Lara Kular, Michael Gubanski, Jiri Bartek, Maja Jagodic
Pubblicato in: Brain, Numero 148, 2025, Pagina/e 3026-3028, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awaf270

Epigenetic age acceleration as a biomarker of amyotrophic lateral sclerosis severity?

Autori: Sebastian A. Lewandowski, Lara Kular, Maja Jagodic
Pubblicato in: eBioMedicine, Numero 110, 2024, Pagina/e 105470, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2024.105470

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